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Cellosaurus SCCT9 (CVCL_VJ50)

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Cell line name SCCT9
Synonyms SCC T9; T9
Accession CVCL_VJ50
Resource Identification Initiative To cite this cell line use: SCCT9 (RRID:CVCL_VJ50)
Comments Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Right hand, skin; UBERON=UBERON_0001519.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Pro48Leu (c.143C>T); Zygosity=Unspecified (PubMed=24662767).
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012604; Zygosity=Unspecified (PubMed=24662767).
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Asp107Gly (c.320A>G); Zygosity=Unspecified (PubMed=24662767).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; c.403+1G>A; Zygosity=Unspecified; Note=Splice donor mutation (PubMed=24662767).
  • Mutation; HGNC; HGNC:7882; NOTCH2; Simple; p.Cys1089Tyr (c.3266G>A); Zygosity=Unspecified (PubMed=24662767).
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_LN09 ! MET-1
CVCL_LN10 ! MET-2
CVCL_LN11 ! MET-3
CVCL_LN12 ! MET-4
CVCL_LN13 ! PM-1 [Human oral dysplasia]
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
STR profile Source(s): PubMed=31336867

Markers:
AmelogeninX,Y
CSF1PO9,13
D2S133817,21
D3S135814,16
D5S81811,12
D7S8207,8
D8S117912,15
D13S3178,12
D16S53911,13
D18S5118,19
D19S43314
D21S1130.2,33.2
FGA24
TH018,9.3
TPOX9,11
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=24662767; DOI=10.1038/jid.2014.154; PMCID=PMC4753672
Andrew P. South, Karin J. Purdie, Stephen A. Watt, Sam Haldenby, Nicoline Y. den Breems, Michelle Dimon, Sarah T. Arron, Michael J. Kluk, Jon Christopher Aster, Angela McHugh, Dylan J. Xue ...Show all 17 authors... , Jasbani H.S. Dayal, Kim S. Robinson, S.M. Hasan Rizvi, Charlotte Mary Proby, Catherine A. Harwood, Irene May Leigh; Show fewer authors
NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis.
J. Invest. Dermatol. 134:2630-2638(2014)

PubMed=30202019; DOI=10.1038/s41467-018-06027-1; PMCID=PMC6131170
Gareth J. Inman, Jun Wang, Ai Nagano, Ludmil B. Alexandrov, Karin J. Purdie, Richard G. Taylor, Victoria Sherwood, Jason Thomson, Sarah Hogan, Lindsay C. Spender, Andrew P. South ...Show all 16 authors... , Michael Rudolf Stratton, Claude Chelala, Catherine A. Harwood, Charlotte Mary Proby, Irene May Leigh; Show fewer authors
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.
Nat. Commun. 9:3667.1-3667.14(2018)

PubMed=31336867; DOI=10.3390/ijms20143428; PMCID=PMC6678499
Sakinah Hassan, Karin J. Purdie, Jun Wang, Catherine A. Harwood, Charlotte Mary Proby, Celine Pourreyron, Nikol Mladkova, Ai Nagano, Sandeep Dhayade, Dimitris Athineos, Matthew Caley ...Show all 15 authors... , Viviana Mannella, Karen Blyth, Gareth J. Inman, Irene May Leigh; Show fewer authors
A Unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing.
Int. J. Mol. Sci. 20:3428.1-3428.26(2019)

Cross-references
Cell line collections (Providers) CancerTools; 153667
Ximbio; 153667
Cell line databases/resources cancercelllines; CVCL_VJ50
Encyclopedic resources Wikidata; Q98129392
Polymorphism and mutation databases Cosmic; 2688678
Entry history
Entry creation07-Sep-2018
Last entry update10-Apr-2025
Version number13