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Cellosaurus MET-1 (CVCL_LN09)

[Text version]
Cell line name MET-1
Synonyms MET1; SCCT
Accession CVCL_LN09
Resource Identification Initiative To cite this cell line use: MET-1 (RRID:CVCL_LN09)
Comments Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Hand, skin; UBERON=UBERON_0001519.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_LN10 ! MET-2
CVCL_LN11 ! MET-3
CVCL_LN12 ! MET-4
CVCL_LN13 ! PM-1 [Human oral dysplasia]
CVCL_VJ50 ! SCCT9
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): PubMed=31336867

Markers:
AmelogeninX,Y
CSF1PO13
D2S133817,21
D3S135816
D5S81811,12
D7S8207,8
D8S117912,15
D13S3178,12
D16S53911,13
D18S5118,19
D19S43314
D21S1130.2,33.2
FGA24
TH019.3
TPOX9,11
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=10772384; DOI=10.1034/j.1600-0625.2000.009002104.x
Charlotte Mary Proby, Karin J. Purdie, Connie J. Sexton, Patricia Purkis, Harshad Ambaram Navsaria, Jeremy N. Stables, Irene May Leigh;
Spontaneous keratinocyte cell lines representing early and advanced stages of malignant transformation of the epidermis.
Exp. Dermatol. 9:104-117(2000)

PubMed=11121147; DOI=10.1046/j.1523-1747.2000.00173.x
Susanne Popp, Stefan Waltering, Heidi Holtgreve-Grez, Anna Jauch, Charlotte Mary Proby, Irene May Leigh, Petra Boukamp;
Genetic characterization of a human skin carcinoma progression model: from primary tumor to metastasis.
J. Invest. Dermatol. 115:1095-1103(2000)

PubMed=24662767; DOI=10.1038/jid.2014.154; PMCID=PMC4753672
Andrew P. South, Karin J. Purdie, Stephen A. Watt, Sam Haldenby, Nicoline Y. den Breems, Michelle Dimon, Sarah T. Arron, Michael J. Kluk, Jon Christopher Aster, Angela McHugh, Dylan J. Xue ...Show all 17 authors... , Jasbani H.S. Dayal, Kim S. Robinson, S.M. Hasan Rizvi, Charlotte Mary Proby, Catherine A. Harwood, Irene May Leigh; Show fewer authors
NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis.
J. Invest. Dermatol. 134:2630-2638(2014)

PubMed=29755650; DOI=10.18632/oncotarget.24750; PMCID=PMC5945540
Angela McHugh, Kenneth Fernandes, Andrew P. South, Jemima Elizabet Mellerio, Julio Cesar Salas-Alanis, Charlotte Mary Proby, Irene May Leigh, Mark K. Saville;
Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity.
Oncotarget 9:20265-20281(2018)

PubMed=30202019; DOI=10.1038/s41467-018-06027-1; PMCID=PMC6131170
Gareth J. Inman, Jun Wang, Ai Nagano, Ludmil B. Alexandrov, Karin J. Purdie, Richard G. Taylor, Victoria Sherwood, Jason Thomson, Sarah Hogan, Lindsay C. Spender, Andrew P. South ...Show all 16 authors... , Michael Rudolf Stratton, Claude Chelala, Catherine A. Harwood, Charlotte Mary Proby, Irene May Leigh; Show fewer authors
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.
Nat. Commun. 9:3667.1-3667.14(2018)

PubMed=31336867; DOI=10.3390/ijms20143428; PMCID=PMC6678499
Sakinah Hassan, Karin J. Purdie, Jun Wang, Catherine A. Harwood, Charlotte Mary Proby, Celine Pourreyron, Nikol Mladkova, Ai Nagano, Sandeep Dhayade, Dimitris Athineos, Matthew Caley ...Show all 15 authors... , Viviana Mannella, Karen Blyth, Gareth J. Inman, Irene May Leigh; Show fewer authors
A Unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing.
Int. J. Mol. Sci. 20:3428.1-3428.26(2019)

Cross-references
Cell line collections (Providers) CancerTools; 153539
Ximbio; 153539
Cell line databases/resources cancercelllines; CVCL_LN09
Encyclopedic resources Wikidata; Q54905316
Gene expression databases GEO; GSM2611467
GEO; GSM2611468
GEO; GSM2611469
Polymorphism and mutation databases Cosmic; 2688659
Entry history
Entry creation15-Nov-2017
Last entry update10-Apr-2025
Version number13