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Cellosaurus MET-2 (CVCL_LN10)

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Cell line name MET-2
Synonyms MET2
Accession CVCL_LN10
Resource Identification Initiative To cite this cell line use: MET-2 (RRID:CVCL_LN10)
Comments Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Hand, skin; UBERON=UBERON_0001519.
Cell type: Keratinocyte; CL=CL_0000312.
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_LN09 ! MET-1
CVCL_LN11 ! MET-3
CVCL_LN12 ! MET-4
CVCL_LN13 ! PM-1 [Human oral dysplasia]
CVCL_VJ50 ! SCCT9
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): PubMed=31336867

Markers:
AmelogeninX,Y
CSF1PO13
D2S133817,21
D3S135816
D5S81811,12
D7S8207,8
D8S117912,15
D13S3178,12
D16S53911,13
D18S5118,19
D19S43314
D21S1130.2,33.2
FGA24
TH019.3
TPOX9,11
vWA18,19

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Publications

PubMed=10772384; DOI=10.1034/j.1600-0625.2000.009002104.x
Charlotte Mary Proby, Karin J. Purdie, Connie J. Sexton, Patricia Purkis, Harshad Ambaram Navsaria, Jeremy N. Stables, Irene May Leigh;
Spontaneous keratinocyte cell lines representing early and advanced stages of malignant transformation of the epidermis.
Exp. Dermatol. 9:104-117(2000)

PubMed=11121147; DOI=10.1046/j.1523-1747.2000.00173.x
Susanne Popp, Stefan Waltering, Heidi Holtgreve-Grez, Anna Jauch, Charlotte Mary Proby, Irene May Leigh, Petra Boukamp;
Genetic characterization of a human skin carcinoma progression model: from primary tumor to metastasis.
J. Invest. Dermatol. 115:1095-1103(2000)

PubMed=30202019; DOI=10.1038/s41467-018-06027-1; PMCID=PMC6131170
Gareth J. Inman, Jun Wang, Ai Nagano, Ludmil B. Alexandrov, Karin J. Purdie, Richard G. Taylor, Victoria Sherwood, Jason Thomson, Sarah Hogan, Lindsay C. Spender, Andrew P. South ...Show all 16 authors... , Michael Rudolf Stratton, Claude Chelala, Catherine A. Harwood, Charlotte Mary Proby, Irene May Leigh; Show fewer authors
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.
Nat. Commun. 9:3667.1-3667.14(2018)

PubMed=31336867; DOI=10.3390/ijms20143428; PMCID=PMC6678499
Sakinah Hassan, Karin J. Purdie, Jun Wang, Catherine A. Harwood, Charlotte Mary Proby, Celine Pourreyron, Nikol Mladkova, Ai Nagano, Sandeep Dhayade, Dimitris Athineos, Matthew Caley ...Show all 15 authors... , Viviana Mannella, Karen Blyth, Gareth J. Inman, Irene May Leigh; Show fewer authors
A Unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing.
Int. J. Mol. Sci. 20:3428.1-3428.26(2019)

Cross-references
Cell line collections (Providers) CancerTools; 153569
Ximbio; 153569
Encyclopedic resources Wikidata; Q54905318
Gene expression databases GEO; GSM2611470
GEO; GSM2611471
GEO; GSM2611472
Entry history
Entry creation15-Nov-2017
Last entry update10-Apr-2025
Version number9