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Cellosaurus PM-1 [Human oral dysplasia] (CVCL_LN13)

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Cell line name PM-1 [Human oral dysplasia]
Synonyms PM1
Accession CVCL_LN13
Resource Identification Initiative To cite this cell line use: PM-1 [Human oral dysplasia] (RRID:CVCL_LN13)
Comments Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Forehead, skin; UBERON=UBERON_0016475.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Asn86Ser (c.257A>G); Zygosity=Unspecified (PubMed=24662767).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly177Glu (c.530G>A); Zygosity=Unspecified (PubMed=24662767).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu258Lys (c.772G>A); ClinVar=VCV000012348; Zygosity=Unspecified (PubMed=24662767).
Disease Oral epithelial dysplasia (NCIt: C129863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_LN09 ! MET-1
CVCL_LN10 ! MET-2
CVCL_LN11 ! MET-3
CVCL_LN12 ! MET-4
CVCL_VJ50 ! SCCT9
Sex of cell Male
Age at sampling 46Y
Category Transformed cell line
STR profile Source(s): PubMed=31336867

Markers:
AmelogeninX,Y
CSF1PO9,13
D2S133817,21
D3S135814
D5S81811,12
D7S8207,8
D8S117912,15
D13S3178,12
D16S53911,13
D18S5118,19
D19S43314
D21S1130.2,33.2
FGA24
TH018,9.3
TPOX9,11
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=10772384; DOI=10.1034/j.1600-0625.2000.009002104.x
Charlotte Mary Proby, Karin J. Purdie, Connie J. Sexton, Patricia Purkis, Harshad Ambaram Navsaria, Jeremy N. Stables, Irene May Leigh;
Spontaneous keratinocyte cell lines representing early and advanced stages of malignant transformation of the epidermis.
Exp. Dermatol. 9:104-117(2000)

PubMed=24662767; DOI=10.1038/jid.2014.154; PMCID=PMC4753672
Andrew P. South, Karin J. Purdie, Stephen A. Watt, Sam Haldenby, Nicoline Y. den Breems, Michelle Dimon, Sarah T. Arron, Michael J. Kluk, Jon Christopher Aster, Angela McHugh, Dylan J. Xue ...Show all 17 authors... , Jasbani H.S. Dayal, Kim S. Robinson, S.M. Hasan Rizvi, Charlotte Mary Proby, Catherine A. Harwood, Irene May Leigh; Show fewer authors
NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis.
J. Invest. Dermatol. 134:2630-2638(2014)

PubMed=30202019; DOI=10.1038/s41467-018-06027-1; PMCID=PMC6131170
Gareth J. Inman, Jun Wang, Ai Nagano, Ludmil B. Alexandrov, Karin J. Purdie, Richard G. Taylor, Victoria Sherwood, Jason Thomson, Sarah Hogan, Lindsay C. Spender, Andrew P. South ...Show all 16 authors... , Michael Rudolf Stratton, Claude Chelala, Catherine A. Harwood, Charlotte Mary Proby, Irene May Leigh; Show fewer authors
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.
Nat. Commun. 9:3667.1-3667.14(2018)

PubMed=31336867; DOI=10.3390/ijms20143428; PMCID=PMC6678499
Sakinah Hassan, Karin J. Purdie, Jun Wang, Catherine A. Harwood, Charlotte Mary Proby, Celine Pourreyron, Nikol Mladkova, Ai Nagano, Sandeep Dhayade, Dimitris Athineos, Matthew Caley ...Show all 15 authors... , Viviana Mannella, Karen Blyth, Gareth J. Inman, Irene May Leigh; Show fewer authors
A Unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing.
Int. J. Mol. Sci. 20:3428.1-3428.26(2019)

Cross-references
Cell line collections (Providers) CancerTools; 153571
Ximbio; 153571
Encyclopedic resources Wikidata; Q54947601
Gene expression databases GEO; GSM2611476
GEO; GSM2611477
GEO; GSM2611478
Polymorphism and mutation databases Cosmic; 2688661
Entry history
Entry creation15-Nov-2017
Last entry update10-Apr-2025
Version number13