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Cellosaurus MET-4 (CVCL_LN12)

[Text version]
Cell line name MET-4
Synonyms MET4; SCCTMet
Accession CVCL_LN12
Resource Identification Initiative To cite this cell line use: MET-4 (RRID:CVCL_LN12)
Comments Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Left axillary lymph node; UBERON=UBERON_0001097.
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_LN09 ! MET-1
CVCL_LN10 ! MET-2
CVCL_LN11 ! MET-3
CVCL_LN13 ! PM-1 [Human oral dysplasia]
CVCL_VJ50 ! SCCT9
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): PubMed=31336867

Markers:
AmelogeninX,Y
CSF1PO13
D2S133817,21
D3S135816
D5S81811,12
D7S8207,8
D8S117912,15
D13S3178,12
D16S53911,13
D18S5118,19
D19S43314
D21S1130.2,33.2
FGA24
TH019.3
TPOX9,11
vWA18,19

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Publications

PubMed=10772384; DOI=10.1034/j.1600-0625.2000.009002104.x
Charlotte Mary Proby, Karin J. Purdie, Connie J. Sexton, Patricia Purkis, Harshad Ambaram Navsaria, Jeremy N. Stables, Irene May Leigh;
Spontaneous keratinocyte cell lines representing early and advanced stages of malignant transformation of the epidermis.
Exp. Dermatol. 9:104-117(2000)

PubMed=11121147; DOI=10.1046/j.1523-1747.2000.00173.x
Susanne Popp, Stefan Waltering, Heidi Holtgreve-Grez, Anna Jauch, Charlotte Mary Proby, Irene May Leigh, Petra Boukamp;
Genetic characterization of a human skin carcinoma progression model: from primary tumor to metastasis.
J. Invest. Dermatol. 115:1095-1103(2000)

PubMed=29755650; DOI=10.18632/oncotarget.24750; PMCID=PMC5945540
Angela McHugh, Kenneth Fernandes, Andrew P. South, Jemima Elizabet Mellerio, Julio Cesar Salas-Alanis, Charlotte Mary Proby, Irene May Leigh, Mark K. Saville;
Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity.
Oncotarget 9:20265-20281(2018)

PubMed=30202019; DOI=10.1038/s41467-018-06027-1; PMCID=PMC6131170
Gareth J. Inman, Jun Wang, Ai Nagano, Ludmil B. Alexandrov, Karin J. Purdie, Richard G. Taylor, Victoria Sherwood, Jason Thomson, Sarah Hogan, Lindsay C. Spender, Andrew P. South ...Show all 16 authors... , Michael Rudolf Stratton, Claude Chelala, Catherine A. Harwood, Charlotte Mary Proby, Irene May Leigh; Show fewer authors
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.
Nat. Commun. 9:3667.1-3667.14(2018)

PubMed=31336867; DOI=10.3390/ijms20143428; PMCID=PMC6678499
Sakinah Hassan, Karin J. Purdie, Jun Wang, Catherine A. Harwood, Charlotte Mary Proby, Celine Pourreyron, Nikol Mladkova, Ai Nagano, Sandeep Dhayade, Dimitris Athineos, Matthew Caley ...Show all 15 authors... , Viviana Mannella, Karen Blyth, Gareth J. Inman, Irene May Leigh; Show fewer authors
A Unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing.
Int. J. Mol. Sci. 20:3428.1-3428.26(2019)

Cross-references
Cell line collections (Providers) CancerTools; 153570
Ximbio; 153570
Encyclopedic resources Wikidata; Q54905320
Gene expression databases GEO; GSM2611473
GEO; GSM2611474
GEO; GSM2611475
Entry history
Entry creation15-Nov-2017
Last entry update10-Apr-2025
Version number9