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Cellosaurus RPTEC/TERT1 (CVCL_K278)

[Text version]
Cell line name RPTEC/TERT1
Synonyms RPTEC TERT1; RPTEC/TERT 1; RPTec; Renal Proximal Tubule Epithelial Cells/TERT-immortalized 1
Accession CVCL_K278
Resource Identification Initiative To cite this cell line use: RPTEC/TERT1 (RRID:CVCL_K278)
Comments Part of: Human Protein Atlas, Cell Atlas panel.
Doubling time: ~96 hours (PubMed=18715936); 76.8 hours (PubMed=31078587); 72-96 hours (Evercyte=CHT-003-0002).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Omics: Metabolomics.
Omics: Proteomics; Expression; Large antibody panel staining analysis.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134.
Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_WN16 (HREC24T)CVCL_WN15 (HRTPT)CVCL_RM67 (RPTEC/TERT1 OAT1)
CVCL_VR68 (RPTEC/TERT1 OAT3)CVCL_RM66 (RPTEC/TERT1 OCT2)CVCL_C1BM (RPTEC_APC_488)
CVCL_C1BN (RPTEC_ATM_451)CVCL_C1BP (RPTEC_ATM_535)CVCL_C1BQ (RPTEC_ATRX_932)
CVCL_C1BR (RPTEC_CDKN2A_10)CVCL_C1BS (RPTEC_CDKN2A_13)CVCL_C1BT (RPTEC_CDKN2A_3)
CVCL_C1BU (RPTEC_EZH2_1)CVCL_C1BV (RPTEC_EZH2_3)CVCL_C1BW (RPTEC_MLH1_905)
CVCL_C1BX (RPTEC_MSH2_495)CVCL_C1BY (RPTEC_MSH2_525)CVCL_C1BZ (RPTEC_MSH6_540)
CVCL_C1C0 (RPTEC_MSH6_541)CVCL_C1C1 (RPTEC_MSH6_543)CVCL_C1CJ (RPTEC_MTAP_A3)
CVCL_C1CK (RPTEC_MTAP_C6)CVCL_C1C2 (RPTEC_NOTCH1_550)CVCL_C1C3 (RPTEC_NOTCH1_552)
CVCL_C1C4 (RPTEC_NOTCH1_606)CVCL_C1C5 (RPTEC_PTEN_3)CVCL_C1C6 (RPTEC_PTEN_4)
CVCL_C1C7 (RPTEC_PTEN_5)CVCL_C1C8 (RPTEC_STAG2_943)CVCL_C1C9 (RPTEC_STAG2_944)
CVCL_C1CA (RPTEC_STAG2_946)CVCL_C1CB (RPTEC_TP53_471)CVCL_C1CC (RPTEC_TP53_544)
CVCL_C1CD (RPTEC_TP53_588)
Sex of cell Male
Age at sampling Adult
Category Telomerase immortalized cell line
STR profile Source(s): ATCC=CRL-4031

Markers:
AmelogeninX,Y
CSF1PO11
D2S133819,25
D3S135814,16
D5S8189,11
D7S82010
D8S117913,15
D13S31711,13
D16S53911,12
D18S5111,20
D19S43313,15
D21S1129,30
FGA21,22
Penta D10,13
Penta E5,17
TH019,9.3
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; HPA; -; https://www.proteinatlas.org/learn/cellines
Publications

PubMed=18715936; DOI=10.1152/ajprenal.90405.2008
Matthias Wieser, Guido Stadler, Paul Jennings, Berthold Streubel, Walter Pfaller, Peter F. Ambros, Claus Riedl, Hermann Katinger, Johannes Grillari, Regina Grillari-Voglauer;
hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics.
Am. J. Physiol. Renal Physiol. 295:F1365-F1375(2008)

PubMed=21103459; DOI=10.1039/c0mb00146e
James Keith Ellis, Toby James Athersuch, Rachel Cavill, Robert Radford, Craig Slattery, Paul Jennings, Tara McMorrow, Michael P. Ryan, Timothy Mark David Ebbels, Hector Charles Keun;
Metabolic response to low-level toxicant exposure in a novel renal tubule epithelial cell system.
Mol. Biosyst. 7:247-257(2011)

PubMed=25536518; DOI=10.1016/j.tiv.2014.11.015
Daniel Crean, Patricia Bellwon, Lydia Aschauer, Alice Limonciel, Konrad Moenks, Philip G. Hewitt, Tobias Schmidt, Karin Herrgen, Wolfgang Dekant, Arno Lukas, Frederic Yves Bois ...Show all 14 authors... , Anja Wilmes, Paul Jennings, Martin O. Leonard; Show fewer authors
Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testing.
Toxicol. In Vitro 30:128-137(2015)

PubMed=31078587; DOI=10.1016/j.taap.2019.05.007; PMCID=PMC6766375
Swojani Shrestha, Scott H. Garrett, Donald A. Sens, Xu-Dong Zhou, Rachel Guyer, Seema Somji;
Characterization and determination of cadmium resistance of CD133(+)/CD24(+) and CD133(-)/CD24(+) cells isolated from the immortalized human proximal tubule cell line, RPTEC/TERT1.
Toxicol. Appl. Pharmacol. 375:5-16(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-4031
Evercyte; CHT-003-0002
Biological sample resources BioSample; SAMN03471734
Encyclopedic resources Wikidata; Q54951284
Gene expression databases GEO; GSM7701468
GEO; GSM7701471
Metabolomic databases MetaboLights; MTBLS9
Entry history
Entry creation11-Feb-2013
Last entry update14-Aug-2025
Version number22