ID   RPTEC/TERT1
AC   CVCL_K278
SY   RPTEC TERT1; RPTEC/TERT 1; RPTec; Renal Proximal Tubule Epithelial Cells/TERT-immortalized 1
DR   ATCC; CRL-4031
DR   BioSample; SAMN03471734
DR   Evercyte; CHT-003-0002
DR   GEO; GSM7701468
DR   GEO; GSM7701471
DR   MetaboLights; MTBLS9
DR   Wikidata; Q54951284
RX   PubMed=18715936;
RX   PubMed=21103459;
RX   PubMed=25536518;
RX   PubMed=31078587;
WW   Info; HPA; -; https://www.proteinatlas.org/learn/cellines
CC   Part of: Human Protein Atlas, Cell Atlas panel.
CC   Doubling time: ~96 hours (PubMed=18715936); 76.8 hours (PubMed=31078587); 72-96 hours (Evercyte=CHT-003-0002).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Omics: Metabolomics.
CC   Omics: Proteomics; Expression; Large antibody panel staining analysis.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134.
CC   Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.
ST   Source(s): ATCC=CRL-4031
ST   Amelogenin: X,Y
ST   CSF1PO: 11
ST   D13S317: 11,13
ST   D16S539: 11,12
ST   D18S51: 11,20
ST   D19S433: 13,15
ST   D21S11: 29,30
ST   D2S1338: 19,25
ST   D3S1358: 14,16
ST   D5S818: 9,11
ST   D7S820: 10
ST   D8S1179: 13,15
ST   FGA: 21,22
ST   Penta D: 10,13
ST   Penta E: 5,17
ST   TH01: 9,9.3
ST   TPOX: 8,11
ST   vWA: 16,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Adult
CA   Telomerase immortalized cell line
DT   Created: 11-02-13; Last updated: 10-04-25; Version: 21
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RX   PubMed=18715936; DOI=10.1152/ajprenal.90405.2008;
RA   Wieser M., Stadler G., Jennings P., Streubel B., Pfaller W.,
RA   Ambros P.F., Riedl C., Katinger H., Grillari J., Grillari-Voglauer R.;
RT   "hTERT alone immortalizes epithelial cells of renal proximal tubules
RT   without changing their functional characteristics.";
RL   Am. J. Physiol. Renal Physiol. 295:F1365-F1375(2008).
//
RX   PubMed=21103459; DOI=10.1039/c0mb00146e;
RA   Ellis J.K., Athersuch T.J., Cavill R., Radford R., Slattery C.,
RA   Jennings P., McMorrow T., Ryan M.P., Ebbels T.M.D., Keun H.C.;
RT   "Metabolic response to low-level toxicant exposure in a novel renal
RT   tubule epithelial cell system.";
RL   Mol. Biosyst. 7:247-257(2011).
//
RX   PubMed=25536518; DOI=10.1016/j.tiv.2014.11.015;
RA   Crean D., Bellwon P., Aschauer L., Limonciel A., Moenks K., Hewitt P.G.,
RA   Schmidt T., Herrgen K., Dekant W., Lukas A., Bois F.Y., Wilmes A.,
RA   Jennings P., Leonard M.O.;
RT   "Development of an in vitro renal epithelial disease state model for
RT   xenobiotic toxicity testing.";
RL   Toxicol. In Vitro 30:128-137(2015).
//
RX   PubMed=31078587; DOI=10.1016/j.taap.2019.05.007; PMCID=PMC6766375;
RA   Shrestha S., Garrett S.H., Sens D.A., Zhou X.-D., Guyer R., Somji S.;
RT   "Characterization and determination of cadmium resistance of
RT   CD133(+)/CD24(+) and CD133(-)/CD24(+) cells isolated from the
RT   immortalized human proximal tubule cell line, RPTEC/TERT1.";
RL   Toxicol. Appl. Pharmacol. 375:5-16(2019).
//