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Cellosaurus RPTEC_CDKN2A_10 (CVCL_C1BR)

[Text version]
Cell line name RPTEC_CDKN2A_10
Accession CVCL_C1BR
Resource Identification Initiative To cite this cell line use: RPTEC_CDKN2A_10 (RRID:CVCL_C1BR)
Comments Part of: Cancer Pathway Knockout Panel.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:1787; CDKN2A.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134.
Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_K278 (RPTEC/TERT1)
Sex of cell Male
Age at sampling Adult
Category Telomerase immortalized cell line
Publications

PubMed=35692635; DOI=10.1016/j.isci.2022.104437; PMCID=PMC9184558
Ashley L. Cook, Nicolas Wyhs, Surojit Sur, Blair Ptak, Maria Popoli, Laura Dobbyn, Tasos Papadopoulos, Chetan Bettegowda, Nickolas Papadopoulos, Bert Vogelstein, Shi-Bin Zhou, Kenneth Wayne Kinzler;
An isogenic cell line panel for sequence-based screening of targeted anticancer drugs.
iScience 25:104437.1-104437.13(2022)

Cross-references
Encyclopedic resources Wikidata; Q114312895
Sequence databases EGA; EGAD00001008559
Entry history
Entry creation22-Sep-2022
Last entry update14-Aug-2025
Version number8