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Cellosaurus K1735-M2 (CVCL_F684)

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Cell line name K1735-M2
Synonyms K-1735 M2; K-1735 M-2; K-1735-M-2; K1735M2; K1735 Met 2; M-2; K-1735 subclone M2
Accession CVCL_F684
Resource Identification Initiative To cite this cell line use: K1735-M2 (RRID:CVCL_F684)
Comments Characteristics: Highly tumorigenic and metastatic. Derived from a lung metastasis produced by the parent tumor-growing subcutaneously.
Doubling time: 13.8 hours (PubMed=9449709).
Transformant: NCIt; C17231; Ultraviolet radiation.
Sequence variations
  • Mutation; MGI; MGI:97376; Nras; Simple; p.Gly13Asp (c.38G>A); Zygosity=Unspecified (from parent cell line).
Disease Mouse melanoma (NCIt: C21790)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C3H/HeN.
Hierarchy Parent: CVCL_F828 (K1735)
Children:
CVCL_F0SC (K1735-M2 Elm1.0-1)CVCL_F0SD (K1735-M2 Elm1.20-2)CVCL_F0SE (K1735-M2 Elm1.20-3)
CVCL_F0SF (K1735-M2 Elm1.23-1)CVCL_F0SG (K1735-M2 Elm1.6-2)CVCL_F0SH (K1735-M2 Elm1.8-3)
CVCL_E7ZG (K1735-Xmet-21)CVCL_C8SK (M2-CD83)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Web pages Provider; MD Anderson CCAC; -; https://www.mdanderson.org/content/dam/mdanderson/documents/core-facilities/Cytogenetics-and-Cell-Authentication-Core/Cell%20Line%20List%203-23-2022.pdf
Publications

PubMed=6750200; DOI=10.1093/jnci/69.4.975
James E. Talmadge, Isaiah Joshua Fidler;
Enhanced metastatic potential of tumor cells harvested from spontaneous metastases of heterogeneous murine tumors.
J. Natl. Cancer Inst. 69:975-980(1982)

PubMed=3756870
Isaiah Joshua Fidler, James E. Talmadge;
Evidence that intravenously derived murine pulmonary melanoma metastases can originate from the expansion of a single tumor cell.
Cancer Res. 46:5167-5171(1986)

PubMed=3370643
Gabriele Schackert, Isaiah Joshua Fidler;
Site-specific metastasis of mouse melanomas and a fibrosarcoma in the brain or meninges of syngeneic animals.
Cancer Res. 48:3478-3484(1988)

PubMed=1826230
Ruo-Dan Zhang, Janet E. Price, Gabriele Schackert, Kyogo Itoh, Isaiah Joshua Fidler;
Malignant potential of cells isolated from lymph node or brain metastases of melanoma patients and implications for prognosis.
Cancer Res. 51:2029-2035(1991)

PubMed=9449709; DOI=10.1084/jem.187.3.289; PMCID=PMC2212122
Yasunobu Hashimoto, Nobuko Shindo-Okada, Masachika Tani, Yasuhiro Nagamachi, Kaori Takeuchi, Toshihiko Shiroishi, Hiroshi Toma, Jun Yokota;
Expression of the Elm1 gene, a novel gene of the CCN (connective tissue growth factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family, suppresses In vivo tumor growth and metastasis of K-1735 murine melanoma cells.
J. Exp. Med. 187:289-296(1998)

PubMed=11820393; DOI=10.1007/s002490100173
Helmut Ahammer, Trevor Thomas Joseph DeVaney, Helmut A. Tritthart;
Fractal dimension of K1735 mouse melanoma clones and spheroid invasion in vitro.
Eur. Biophys. J. 30:494-499(2001)

Cross-references
Encyclopedic resources Wikidata; Q54899262
Entry history
Entry creation11-Feb-2013
Last entry update27-Nov-2025
Version number10