Cell line name |
Huh-7.5.1 |
Synonyms |
Huh 7.5.1; Huh7.5.1 |
Accession |
CVCL_E049 |
Resource Identification Initiative |
To cite this cell line use: Huh-7.5.1 (RRID:CVCL_E049) |
Comments |
Population: Japanese. Virology: Compared to the parent Huh-7 cell line, permits improved hepatitis C virus (HCV) production when infected with strain JFH-1. Derived from site: In situ; Liver; UBERON=UBERON_0002107. |
Sequence variations |
- Mutation; HGNC; HGNC:6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:19102; RIGI; Simple; p.Thr55Ile (c.164C>T); Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
|
Disease |
Adult hepatocellular carcinoma (NCIt: C7956) Adult hepatocellular carcinoma (ORDO: Orphanet_210159) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_7927 (Huh-7.5) Children:
|
Sex of cell |
Male |
Age at sampling |
57Y |
Category |
Cancer cell line |
Publications | PubMed=15939869; DOI=10.1073/pnas.0503596102; PMCID=PMC1166622 Jin Zhong, Pablo Gastaminza, Guo-Feng Cheng, Sharookh Kapadia, Takanobu Kato, Dennis R. Burton, Stefan F. Wieland, Susan L. Uprichard, Takaji Wakita, Francis Vincent Chisari; Robust hepatitis C virus infection in vitro. Proc. Natl. Acad. Sci. U.S.A. 102:9294-9299(2005) PubMed=23285155; DOI=10.1371/journal.pone.0052697; PMCID=PMC3527576 Asako Murayama, Nao Sugiyama, Seiko Yoshimura, Mitsuko Ishihara-Sugano, Takahiro Masaki, Sulyi Kim, Takaji Wakita, Shunji Mishiro, Takanobu Kato; A subclone of HuH-7 with enhanced intracellular hepatitis C virus production and evasion of virus related-cell cycle arrest. PLoS ONE 7:e52697.1-e52697.9(2012) PubMed=25420655; DOI=10.7883/yoken.JJID.2014.231 Yoshitaka Shirasago, Tsuyoshi Sekizuka, Kyoko Saito, Tetsuro Suzuki, Takaji Wakita, Kentaro Hanada, Makoto Kuroda, Ryo Abe, Masayoshi Fukasawa; Isolation and characterization of an Huh.7.5.1-derived cell clone highly permissive to hepatitis C virus. Jpn. J. Infect. Dis. 68:81-88(2015) |
Cross-references |
Cell line collections (Providers) |
CCTCC; GDC0137
|
Cell line databases/resources |
cancercelllines; CVCL_E049
|
Anatomy/cell type resources |
BTO; BTO_0005463
|
CRISP screens repositories |
BioGRID_ORCS_Cell_line; 735
|
Chemistry resources |
ChEMBL-Cells; CHEMBL4483152
ChEMBL-Targets; CHEMBL4483247
PubChem_Cell_line; CVCL_E049
|
Encyclopedic resources |
Wikidata; Q54896857
|
Entry history |
Entry creation | 22-Oct-2012 |
Last entry update | 19-Dec-2024 |
Version number | 24 |
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