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Cellosaurus Huh-7.5.1-ACE2 (CVCL_C9AS)

[Text version]
Cell line name Huh-7.5.1-ACE2
Accession CVCL_C9AS
Resource Identification Initiative To cite this cell line use: Huh-7.5.1-ACE2 (RRID:CVCL_C9AS)
Comments Population: Japanese.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:13557; ACE2.
Omics: Phenotyping; CRISPR screening.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:19102; RIGI; Simple; p.Thr55Ile (c.164C>T); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E049 (Huh-7.5.1)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
Publications

PubMed=35879413; DOI=10.1038/s41588-022-01110-2
Antoine Rebendenne, Priyanka Roy, Boris Bonaventure, Ana Luiza Chaves Valadao, Lowiese M.B. Desmarets, Mary Arnaud-Arnould, Yves Rouille, Marine Tauziet, Donatella Giovannini, Jawida Touhami, Yenarae Lee ...Show all 23 authors... , Peter DeWeirdt, Mudra Hegde, Serge Urbach, Khadija El Koulali, Francisco Garcia de Gracia, Joe McKellar, Jean Dubuisson, Melanie Wencker, Sandrine Belouzard, Olivier Moncorge, John G. Doench, Caroline Goujon; Show fewer authors
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.
Nat. Genet. 54:1090-1102(2022)

Cross-references
CRISP screens repositories BioGRID_ORCS_Cell_line; 1716
Encyclopedic resources Wikidata; Q123032648
Entry history
Entry creation05-Oct-2023
Last entry update10-Apr-2025
Version number5