Cell line name |
Huh-7.5.1-ACE2 |
Accession |
CVCL_C9AS |
Resource Identification Initiative |
To cite this cell line use: Huh-7.5.1-ACE2 (RRID:CVCL_C9AS) |
Comments |
Population: Japanese. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:13557; ACE2. Omics: Phenotyping; CRISPR screening. Derived from site: In situ; Liver; UBERON=UBERON_0002107. |
Sequence variations |
- Mutation; HGNC; HGNC:6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:19102; RIGI; Simple; p.Thr55Ile (c.164C>T); Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
|
Disease |
Adult hepatocellular carcinoma (NCIt: C7956) Adult hepatocellular carcinoma (ORDO: Orphanet_210159) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_E049 (Huh-7.5.1) |
Sex of cell |
Male |
Age at sampling |
57Y |
Category |
Cancer cell line |
Publications | PubMed=35879413; DOI=10.1038/s41588-022-01110-2 Antoine Rebendenne, Priyanka Roy, Boris Bonaventure, Ana Luiza Chaves Valadao, Lowiese M.B. Desmarets, Mary Arnaud-Arnould, Yves Rouille, Marine Tauziet, Donatella Giovannini, Jawida Touhami, Yenarae Lee ...Show all 23 authors... , Peter DeWeirdt, Mudra Hegde, Serge Urbach, Khadija El Koulali, Francisco Garcia de Gracia, Joe McKellar, Jean Dubuisson, Melanie Wencker, Sandrine Belouzard, Olivier Moncorge, John G. Doench, Caroline Goujon; Show fewer authors Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs. Nat. Genet. 54:1090-1102(2022) |
Cross-references |
CRISP screens repositories |
BioGRID_ORCS_Cell_line; 1716
|
Encyclopedic resources |
Wikidata; Q123032648
|
Entry history |
Entry creation | 05-Oct-2023 |
Last entry update | 10-Apr-2025 |
Version number | 5 |
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