ID   Huh-7.5.1-ACE2
AC   CVCL_C9AS
DR   BioGRID_ORCS_Cell_line; 1716
DR   Wikidata; Q123032648
RX   PubMed=35879413;
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 19102; RIGI; Simple; p.Thr55Ile (c.164C>T); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: HGNC; 13557; ACE2.
CC   Omics: CRISPR phenotypic screen.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_E049 ! Huh-7.5.1
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 30-01-24; Version: 2
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RX   PubMed=35879413; DOI=10.1038/s41588-022-01110-2;
RA   Rebendenne A., Roy P., Bonaventure B., Chaves Valadao A.L.,
RA   Desmarets L.M.B., Arnaud-Arnould M., Rouille Y., Tauziet M.,
RA   Giovannini D., Touhami J., Lee Y., DeWeirdt P., Hegde M., Urbach S.,
RA   El Koulali K., de Gracia F.G., McKellar J., Dubuisson J., Wencker M.,
RA   Belouzard S., Moncorge O., Doench J.G., Goujon C.;
RT   "Bidirectional genome-wide CRISPR screens reveal host factors
RT   regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.";
RL   Nat. Genet. 54:1090-1102(2022).
//