ID   Huh-7.5.1
AC   CVCL_E049
SY   Huh 7.5.1; Huh7.5.1
DR   BTO; BTO_0005463
DR   BioGRID_ORCS_Cell_line; 735
DR   cancercelllines; CVCL_E049
DR   CCTCC; GDC0137
DR   ChEMBL-Cells; CHEMBL4483152
DR   ChEMBL-Targets; CHEMBL4483247
DR   PubChem_Cell_line; CVCL_E049
DR   Wikidata; Q54896857
RX   PubMed=15939869;
RX   PubMed=23285155;
RX   PubMed=25420655;
CC   Population: Japanese.
CC   Virology: Compared to the parent Huh-7 cell line, permits improved hepatitis C virus (HCV) production when infected with strain JFH-1.
CC   Sequence variation: Mutation; HGNC; HGNC:6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:19102; RIGI; Simple; p.Thr55Ile (c.164C>T); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_7927 ! Huh-7.5
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 24
CH   CVCL_YU21 ! Huh7.5.1-5
CH   CVCL_C9AS ! Huh-7.5.1-ACE2
CH   CVCL_YU20 ! Huh7.5.1-8
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RX   PubMed=23285155; DOI=10.1371/journal.pone.0052697; PMCID=PMC3527576;
RA   Murayama, Asako
RA   Sugiyama, Nao
RA   Yoshimura, Seiko
RA   Ishihara-Sugano, Mitsuko
RA   Masaki, Takahiro
RA   Kim, Sulyi
RA   Wakita, Takaji
RA   Mishiro, Shunji
RA   Kato, Takanobu
RT   "A subclone of HuH-7 with enhanced intracellular hepatitis C virus
RT   production and evasion of virus related-cell cycle arrest.";
RL   PLoS ONE 7:e52697.1-e52697.9(2012).
//
RX   PubMed=25420655; DOI=10.7883/yoken.JJID.2014.231;
RA   Shirasago, Yoshitaka
RA   Sekizuka, Tsuyoshi
RA   Saito, Kyoko
RA   Suzuki, Tetsuro
RA   Wakita, Takaji
RA   Hanada, Kentaro
RA   Kuroda, Makoto
RA   Abe, Ryo
RA   Fukasawa, Masayoshi
RT   "Isolation and characterization of an Huh.7.5.1-derived cell clone
RT   highly permissive to hepatitis C virus.";
RL   Jpn. J. Infect. Dis. 68:81-88(2015).
//
RX   PubMed=15939869; DOI=10.1073/pnas.0503596102; PMCID=PMC1166622;
RA   Zhong, Jin
RA   Gastaminza, Pablo
RA   Cheng, Guo-Feng
RA   Kapadia, Sharookh
RA   Kato, Takanobu
RA   Burton, Dennis R.
RA   Wieland, Stefan F.
RA   Uprichard, Susan L.
RA   Wakita, Takaji
RA   Chisari, Francis Vincent
RT   "Robust hepatitis C virus infection in vitro.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:9294-9299(2005).
//