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Cellosaurus Huh7.5.1-5 (CVCL_YU21)

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Cell line name Huh7.5.1-5
Accession CVCL_YU21
Resource Identification Initiative To cite this cell line use: Huh7.5.1-5 (RRID:CVCL_YU21)
Comments Population: Japanese.
Virology: CD81-defective clone not susceptible to infection by hepatitis C virus (HCV).
Omics: Genomics; Whole genome sequencing.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:19102; RIGI; Simple; p.Thr55Ile (c.164C>T); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E049 (Huh-7.5.1)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
Publications

PubMed=25420655; DOI=10.7883/yoken.JJID.2014.231
Yoshitaka Shirasago, Tsuyoshi Sekizuka, Kyoko Saito, Tetsuro Suzuki, Takaji Wakita, Kentaro Hanada, Makoto Kuroda, Ryo Abe, Masayoshi Fukasawa;
Isolation and characterization of an Huh.7.5.1-derived cell clone highly permissive to hepatitis C virus.
Jpn. J. Infect. Dis. 68:81-88(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YU21
Encyclopedic resources Wikidata; Q94308754
Entry history
Entry creation12-Mar-2020
Last entry update10-Apr-2025
Version number12