ID   Huh7.5.1-5
AC   CVCL_YU21
DR   cancercelllines; CVCL_YU21
DR   Wikidata; Q94308754
RX   PubMed=25420655;
CC   Population: Japanese.
CC   Virology: CD81-defective clone not susceptible to infection by hepatitis C virus (HCV).
CC   Sequence variation: Mutation; HGNC; HGNC:6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:19102; RIGI; Simple; p.Thr55Ile (c.164C>T); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
CC   Omics: Genomics; Whole genome sequencing.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_E049 ! Huh-7.5.1
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 12-03-20; Last updated: 10-04-25; Version: 12
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RX   PubMed=25420655; DOI=10.7883/yoken.JJID.2014.231;
RA   Shirasago, Yoshitaka
RA   Sekizuka, Tsuyoshi
RA   Saito, Kyoko
RA   Suzuki, Tetsuro
RA   Wakita, Takaji
RA   Hanada, Kentaro
RA   Kuroda, Makoto
RA   Abe, Ryo
RA   Fukasawa, Masayoshi
RT   "Isolation and characterization of an Huh.7.5.1-derived cell clone
RT   highly permissive to hepatitis C virus.";
RL   Jpn. J. Infect. Dis. 68:81-88(2015).
//