Cellosaurus HEK293-CNG-Gs (CVCL_C0RW)
| Cell line name | HEK293-CNG-Gs | ||||
|---|---|---|---|---|---|
| Synonyms | HEK 293-CNG-Gs | ||||
| Accession | CVCL_C0RW | ||||
| Resource Identification Initiative | To cite this cell line use: HEK293-CNG-Gs (RRID:CVCL_C0RW) | ||||
| Comments | Characteristics: Expresses a modified cyclic nucleotide gated (CNG) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. Allows sensitive detection of signaling by Gs, Gi or Gq-coupled receptors (Dexorgen). Characteristics: Expresses a constitutively active over-expressed Gs-coupled GPCR. Serves as a parent cell line for various ACTOne PDE cell lines. Genetic integration: Method=Transduction; Gene=RGD; 2367; Cnga2 (Note=With p.Phe68Ala, p.Trp81Ala, p.Cys460Trp and p.Glu583Met = oCNG-NC). Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR). Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Transformant: NCBI_TaxID; 28285; Adenovirus 5. Miscellaneous: Has Dexorgen catalog number CB-81200-100, but not distributed separately from children cell lines. Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113. | ||||
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||
| Hierarchy | Parent: CVCL_0045 (HEK293) Children:
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| Sex of cell | Female | ||||
| Age at sampling | Fetus | ||||
| Category | Transformed cell line | ||||
| Cross-references | |||||
| Encyclopedic resources | Wikidata; Q112929680 | ||||
| Entry history | |||||
| Entry creation | 23-Jun-2022 | ||||
| Last entry update | 10-Apr-2025 | ||||
| Version number | 6 | ||||