ID   HEK293-CNG-Gs
AC   CVCL_C0RW
SY   HEK 293-CNG-Gs
DR   Wikidata; Q112929680
CC   Characteristics: Expresses a modified cyclic nucleotide gated (CNG) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. Allows sensitive detection of signaling by Gs, Gi or Gq-coupled receptors (Dexorgen).
CC   Characteristics: Expresses a constitutively active over-expressed Gs-coupled GPCR. Serves as a parent cell line for various ACTOne PDE cell lines.
CC   Genetic integration: Method=Transduction; Gene=RGD; 2367; Cnga2 (Note=With p.Phe68Ala, p.Trp81Ala, p.Cys460Trp and p.Glu583Met = oCNG-NC).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 28285; Adenovirus 5.
CC   Miscellaneous: Has Dexorgen catalog number CB-81200-100, but not distributed separately from children cell lines.
CC   Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0045 ! HEK293
SX   Female
AG   Fetus
CA   Transformed cell line
DT   Created: 23-06-22; Last updated: 10-04-25; Version: 6
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