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Cellosaurus ACTOne cAMP-PDE2A (CVCL_C0TI)

[Text version]
Cell line name ACTOne cAMP-PDE2A
Synonyms ACTOne PDE2A
Accession CVCL_C0TI
Resource Identification Initiative To cite this cell line use: ACTOne cAMP-PDE2A (RRID:CVCL_C0TI)
Comments Characteristics: Expresses a modified cyclic nucleotide gated (CNG) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. Allows sensitive detection of signaling by Gs, Gi or Gq-coupled receptors (Dexorgen).
Characteristics: Expresses a constitutively active over-expressed Gs-coupled GPCR (Dexorgen).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:8777; PDE2A.
Genetic integration: Method=Transduction; Gene=RGD; 2367; Cnga2 (Note=With p.Phe68Ala, p.Trp81Ala, p.Cys460Trp and p.Glu583Met = oCNG-NC).
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 28285; Adenovirus 5.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C0RW (HEK293-CNG-Gs)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Web pages Provider; Dexorgen; CB-81200-101; https://www.dexorgen.com/actone-cell-lines/
Cross-references
Encyclopedic resources Wikidata; Q112929184
Entry history
Entry creation23-Jun-2022
Last entry update10-Apr-2025
Version number8