ID   ACTOne cAMP-PDE2A
AC   CVCL_C0TI
SY   ACTOne PDE2A
DR   Wikidata; Q112929184
WW   Provider; Dexorgen; CB-81200-101; https://www.dexorgen.com/actone-cell-lines/
CC   Characteristics: Expresses a modified cyclic nucleotide gated (CNG) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. Allows sensitive detection of signaling by Gs, Gi or Gq-coupled receptors (Dexorgen).
CC   Characteristics: Expresses a constitutively active over-expressed Gs-coupled GPCR (Dexorgen).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:8777; PDE2A.
CC   Genetic integration: Method=Transduction; Gene=RGD; 2367; Cnga2 (Note=With p.Phe68Ala, p.Trp81Ala, p.Cys460Trp and p.Glu583Met = oCNG-NC).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 28285; Adenovirus 5.
CC   Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C0RW ! HEK293-CNG-Gs
SX   Female
AG   Fetus
CA   Transformed cell line
DT   Created: 23-06-22; Last updated: 10-04-25; Version: 8
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