Cellosaurus ACTOne cAMP-PDE10A (CVCL_C0TF)
| Cell line name | ACTOne cAMP-PDE10A |
|---|---|
| Synonyms | ACTOne PDE10A |
| Accession | CVCL_C0TF |
| Resource Identification Initiative | To cite this cell line use: ACTOne cAMP-PDE10A (RRID:CVCL_C0TF) |
| Comments | Characteristics: Expresses a modified cyclic nucleotide gated (CNG) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. Allows sensitive detection of signaling by Gs, Gi or Gq-coupled receptors (Dexorgen). Characteristics: Expresses a constitutively active over-expressed Gs-coupled GPCR (Dexorgen). Genetic integration: Method=Transduction; Gene=HGNC; HGNC:8772; PDE10A. Genetic integration: Method=Transduction; Gene=RGD; 2367; Cnga2 (Note=With p.Phe68Ala, p.Trp81Ala, p.Cys460Trp and p.Glu583Met = oCNG-NC). Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; B.cereus Bsr. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR). Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Transformant: NCBI_TaxID; 28285; Adenovirus 5. Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113. |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_C0RW (HEK293-CNG-Gs) |
| Sex of cell | Female |
| Age at sampling | Fetus |
| Category | Transformed cell line |
| Web pages | Provider; Dexorgen; CB-81200-102; https://www.dexorgen.com/actone-cell-lines/ |
| Cross-references | |
| Encyclopedic resources | Wikidata; Q112929181 |
| Entry history | |
| Entry creation | 23-Jun-2022 |
| Last entry update | 10-Apr-2025 |
| Version number | 8 |