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Cellosaurus SW1573/S1 (CVCL_A5BA)

[Text version]
Cell line name SW1573/S1
Synonyms SW-1573/S1; S1
Accession CVCL_A5BA
Resource Identification Initiative To cite this cell line use: SW1573/S1 (RRID:CVCL_A5BA)
Comments Population: Caucasian.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser33Phe (c.98C>T); ClinVar=VCV000017583; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Lys111Glu (c.331A>G); ClinVar=VCV000376482; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11103; SMARCB1; Simple; c.362+1G>C; ClinVar=VCV000582116; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
Disease Minimally invasive lung adenocarcinoma (NCIt: C2923)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1720 (SW1573)
Children:
CVCL_WG69 (SW1573/1R10000)CVCL_WG67 (SW1573/1R50)CVCL_WG68 (SW1573/1R500)
CVCL_WG70 (SW1573/2R120)CVCL_WG75 (SW1573/2R50)CVCL_WG72 (SW1573/3R80)
CVCL_A5BB (SW1573/S1(MDR1))CVCL_A5BC (SW1573/S1(MRP))CVCL_A5BD (SW1573/S1neo)
CVCL_A5BE (SW1573/S1ou)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Publications

PubMed=1348862; DOI=10.1073/pnas.89.8.3498; PMCID=PMC48895
Elisabeth W.H.M. Eijdems, Piet Borst, Ans P.M. Jongsma, Steven de Jong, Elisabeth Geertruida Emma de Vries, Marjon van Groenigen, Carolina H.M. Versantvoort, Aggie W.M. Nieuwint, Frank Baas;
Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype.
Proc. Natl. Acad. Sci. U.S.A. 89:3498-3502(1992)

PubMed=1353703
Aggie W.M. Nieuwint, Frank Baas, Joop Wiegant, Hans Joenje;
Cytogenetic alterations associated with P-glycoprotein- and non-P-glycoprotein-mediated multidrug resistance in SW-1573 human lung tumor cell lines.
Cancer Res. 52:4361-4371(1992)

PubMed=7809167; DOI=10.1073/pnas.91.26.13033; PMCID=PMC45575
Michael Muller, Coby Meijer, Guido J.R. Zaman, Piet Borst, Riekeld J. Scheper, Nanno H. Mulder, Elisabeth Geertruida Emma de Vries, Peter L.M. Jansen;
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.
Proc. Natl. Acad. Sci. U.S.A. 91:13033-13037(1994)

PubMed=7644478; DOI=10.1073/pnas.92.17.7690; PMCID=PMC41211
Guido J.R. Zaman, Jan Lankelma, Olaf van Tellingen, Jos Heindrik Beijnen, Henk Dekker, Coen C. Paulusma, Ronald P.J. Oude Elferink, Frank Baas, Piet Borst;
Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.
Proc. Natl. Acad. Sci. U.S.A. 92:7690-7694(1995)

PubMed=12093475; DOI=10.1016/S0006-2952(02)00983-8
Eelco Fokkema, Harry J.M. Groen, Marco N. Helder, Elisabeth Geertruida Emma de Vries, Coby Meijer;
JM216-, JM118-, and cisplatin-induced cytotoxicity in relation to platinum-DNA adduct formation, glutathione levels and p53 status in human tumour cell lines with different sensitivities to cisplatin.
Biochem. Pharmacol. 63:1989-1996(2002)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5BA
Anatomy/cell type resources BTO; BTO_0006275
Encyclopedic resources Wikidata; Q107116980
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number5