| Cell line name |
SW1573/S1(MRP) |
|---|
| Synonyms |
S1(MRP) |
|---|
| Accession |
CVCL_A5BC |
|---|
| Resource Identification Initiative |
To cite this cell line use: SW1573/S1(MRP) (RRID:CVCL_A5BC) |
|---|
| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:51; ABCC1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Lung; UBERON=UBERON_0002048. |
|---|
| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser33Phe (c.98C>T); ClinVar=VCV000017583; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Lys111Glu (c.331A>G); ClinVar=VCV000376482; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11103; SMARCB1; Simple; c.362+1G>C; ClinVar=VCV000582116; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
|
|---|
| Disease |
Minimally invasive lung adenocarcinoma (NCIt: C2923) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_A5BA (SW1573/S1) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
44Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=7809167; DOI=10.1073/pnas.91.26.13033; PMCID=PMC45575
Michael Muller, Coby Meijer, Guido J.R. Zaman, Piet Borst, Riekeld J. Scheper, Nanno H. Mulder, Elisabeth Geertruida Emma de Vries, Peter L.M. Jansen;
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.
Proc. Natl. Acad. Sci. U.S.A. 91:13033-13037(1994) PubMed=7644478; DOI=10.1073/pnas.92.17.7690; PMCID=PMC41211
Guido J.R. Zaman, Jan Lankelma, Olaf van Tellingen, Jos Heindrik Beijnen, Henk Dekker, Coen C. Paulusma, Ronald P.J. Oude Elferink, Frank Baas, Piet Borst;
Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.
Proc. Natl. Acad. Sci. U.S.A. 92:7690-7694(1995) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_A5BC
|
|---|
| Encyclopedic resources |
Wikidata; Q107116983
|
|---|
| Entry history |
|---|
| Entry creation | 20-May-2021 |
|---|
| Last entry update | 14-Aug-2025 |
|---|
| Version number | 7 |
|---|
