| Cell line name |
SW1573/S1ou |
|---|
| Synonyms |
S1ou |
|---|
| Accession |
CVCL_A5BE |
|---|
| Resource Identification Initiative |
To cite this cell line use: SW1573/S1ou (RRID:CVCL_A5BE) |
|---|
| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_472805; Ouabain.
Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:88105; Atp1a1.
Derived from site: In situ; Lung; UBERON=UBERON_0002048. |
|---|
| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser33Phe (c.98C>T); ClinVar=VCV000017583; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Lys111Glu (c.331A>G); ClinVar=VCV000376482; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11103; SMARCB1; Simple; c.362+1G>C; ClinVar=VCV000582116; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
|
|---|
| Disease |
Minimally invasive lung adenocarcinoma (NCIt: C2923) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_A5BA (SW1573/S1) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
44Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=1348862; DOI=10.1073/pnas.89.8.3498; PMCID=PMC48895
Elisabeth W.H.M. Eijdems, Piet Borst, Ans P.M. Jongsma, Steven de Jong, Elisabeth Geertruida Emma de Vries, Marjon van Groenigen, Carolina H.M. Versantvoort, Aggie W.M. Nieuwint, Frank Baas;
Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype.
Proc. Natl. Acad. Sci. U.S.A. 89:3498-3502(1992) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_A5BE
|
|---|
| Encyclopedic resources |
Wikidata; Q107116987
|
|---|
| Entry history |
|---|
| Entry creation | 20-May-2021 |
|---|
| Last entry update | 19-Dec-2024 |
|---|
| Version number | 6 |
|---|
