• Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  
• Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser33Phe (c.98C>T); ClinVar=VCV000017583; Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Lys111Glu (c.331A>G); ClinVar=VCV000376482; Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; HGNC:11103; SMARCB1; Simple; c.362+1G>C; ClinVar=VCV000582116; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  

CLPUB00485
Catharina M. Kuiper, Henk J. Broxterman, Frank Baas, Gerrit Jan Schuurhuis, Hidde Jacob Haisma, George L. Scheffer, Jan Lankelma, Herbert Michael Pinedo;
Drug transport variants without P-glycoprotein overexpression from a human squamous lung cancer cell line after selection with doxorubicin.
J. Cell. Pharmacol. 1:35-41(1990)

PubMed=1974823
Frank Baas, Ans P.M. Jongsma, Henk J. Broxterman, Robert John Arceci, David E. Housman, George L. Scheffer, Albert Riethorst, Marjon van Groenigen, Aggie W.M. Nieuwint, Hans Joenje;
Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line.
Cancer Res. 50:5392-5398(1990)

PubMed=1353703
Aggie W.M. Nieuwint, Frank Baas, Joop Wiegant, Hans Joenje;
Cytogenetic alterations associated with P-glycoprotein- and non-P-glycoprotein-mediated multidrug resistance in SW-1573 human lung tumor cell lines.
Cancer Res. 52:4361-4371(1992)

PubMed=9256160; DOI=10.1016/S0006-2952(97)82448-3
Baukelien van Triest, Herbert Michael Pinedo, Frank Telleman, Clasina L. van der Wilt, Gerrit Jansen, Godefridus Johannes Peters;
Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression.
Biochem. Pharmacol. 53:1855-1866(1997)