Cell line name |
SW1573/S1(MDR1) |
Synonyms |
S1(MDR1); S1(1.1); S1 1.1 |
Accession |
CVCL_A5BB |
Resource Identification Initiative |
To cite this cell line use: SW1573/S1(MDR1) (RRID:CVCL_A5BB) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_28445; Vincristine (VCR). Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:40; ABCB1. Derived from site: In situ; Lung; UBERON=UBERON_0002048. |
Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser33Phe (c.98C>T); ClinVar=VCV000017583; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Lys111Glu (c.331A>G); ClinVar=VCV000376482; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11103; SMARCB1; Simple; c.362+1G>C; ClinVar=VCV000582116; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
|
Disease |
Minimally invasive lung adenocarcinoma (NCIt: C2923) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_A5BA (SW1573/S1) |
Sex of cell |
Female |
Age at sampling |
44Y |
Category |
Cancer cell line |
Publications | PubMed=1348862; DOI=10.1073/pnas.89.8.3498; PMCID=PMC48895 Elisabeth W.H.M. Eijdems, Piet Borst, Ans P.M. Jongsma, Steven de Jong, Elisabeth Geertruida Emma de Vries, Marjon van Groenigen, Carolina H.M. Versantvoort, Aggie W.M. Nieuwint, Frank Baas; Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype. Proc. Natl. Acad. Sci. U.S.A. 89:3498-3502(1992) PubMed=7644478; DOI=10.1073/pnas.92.17.7690; PMCID=PMC41211 Guido J.R. Zaman, Jan Lankelma, Olaf van Tellingen, Jos Heindrik Beijnen, Henk Dekker, Coen C. Paulusma, Ronald P.J. Oude Elferink, Frank Baas, Piet Borst; Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein. Proc. Natl. Acad. Sci. U.S.A. 92:7690-7694(1995) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_A5BB
|
Encyclopedic resources |
Wikidata; Q107116982
|
Entry history |
Entry creation | 20-May-2021 |
Last entry update | 19-Dec-2024 |
Version number | 6 |
---|