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Cellosaurus SW1573/S1(MDR1) (CVCL_A5BB)

[Text version]
Cell line name SW1573/S1(MDR1)
Synonyms S1(MDR1); S1(1.1); S1 1.1
Accession CVCL_A5BB
Resource Identification Initiative To cite this cell line use: SW1573/S1(MDR1) (RRID:CVCL_A5BB)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28445; Vincristine (VCR).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:40; ABCB1.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser33Phe (c.98C>T); ClinVar=VCV000017583; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Lys111Glu (c.331A>G); ClinVar=VCV000376482; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11103; SMARCB1; Simple; c.362+1G>C; ClinVar=VCV000582116; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
Disease Minimally invasive lung adenocarcinoma (NCIt: C2923)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A5BA (SW1573/S1)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Publications

PubMed=1348862; DOI=10.1073/pnas.89.8.3498; PMCID=PMC48895
Elisabeth W.H.M. Eijdems, Piet Borst, Ans P.M. Jongsma, Steven de Jong, Elisabeth Geertruida Emma de Vries, Marjon van Groenigen, Carolina H.M. Versantvoort, Aggie W.M. Nieuwint, Frank Baas;
Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype.
Proc. Natl. Acad. Sci. U.S.A. 89:3498-3502(1992)

PubMed=7644478; DOI=10.1073/pnas.92.17.7690; PMCID=PMC41211
Guido J.R. Zaman, Jan Lankelma, Olaf van Tellingen, Jos Heindrik Beijnen, Henk Dekker, Coen C. Paulusma, Ronald P.J. Oude Elferink, Frank Baas, Piet Borst;
Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.
Proc. Natl. Acad. Sci. U.S.A. 92:7690-7694(1995)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5BB
Encyclopedic resources Wikidata; Q107116982
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number6