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Cellosaurus BJAB (CVCL_5711)

[Text version]
Cell line name BJAB
Synonyms BJAb; BJA-B; BJAB-1; BJA-B1; BJA-B-1
Accession CVCL_5711
Resource Identification Initiative To cite this cell line use: BJAB (RRID:CVCL_5711)
Comments Part of: LL-100 blood cancer cell line panel.
Population: African; Kenyan.
Virology: EBV-negative. Even so that the original tumor tissue was infected with the B95-8 strain of EBV.
Doubling time: ~22 hours (PubMed=179629); ~40-60 hours (DSMZ=ACC-757).
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Groin; UBERON=UBERON_0008337.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,02:01
HLA-BB*13:02,35:01
HLA-CC*04:01,06:02

Source: CLS=302006
Class I
HLA-AA*01:02:83,02:01:01
HLA-BB*13:02:01,35:01:01
HLA-CC*04:01:01,06:02:01
Class II
HLA-DPDPB1*04:02:01G
HLA-DQDQA1*01:02:01,05:05:01
DQB1*03:01,06:04:01
HLA-DRDRB1*12:01:01,13:02:01

Source: DSMZCellDive=ACC-757
Class I
HLA-AA*02:01:01,02:01:01
HLA-BB*13:02:01,35:01:01
HLA-CC*04:01:01,06:02:01
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*105:01,105:01
HLA-DQDQB1*03:01:01,06:09:01
HLA-DRDRA*01:01:01,01:02:02
DRB1*12:01:01,13:02:01
Disease Burkitt lymphoma (NCIt: C2912)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_8659 (BBF)CVCL_VD92 (BJAB GFP-CD20)CVCL_VD93 (BJAB GFP-MS4A4A)
CVCL_VD94 (BJAB GFP-MS4A6A)CVCL_VD95 (BJAB GFP-MS4A7)CVCL_VD96 (BJAB GFP-MS4A8B)
CVCL_VE00 (BJAB HA-MS4A4A)CVCL_VE01 (BJAB HA-MS4A8B)CVCL_B6UM (BJAB-B95.8.6)
CVCL_IZ94 (BJAB-K20)CVCL_9876 (BJAB-K3)CVCL_IZ95 (BJAB-K43)
CVCL_9666 (BJAB-K5)CVCL_IZ96 (BJAB-K6)CVCL_IZ97 (BJAB-K88)
CVCL_YY30 (BJAB-L-YFP)CVCL_YY31 (BJAB-YFP)CVCL_VC38 (BJAB/ADR)
CVCL_B6UK (BJAB-HR1K)CVCL_8660 (BREM)CVCL_5758 (GC-BJAB)
CVCL_C5DJ (sfBJAB)CVCL_1G52 (TF228.1.16)
Sex of cell Female
Age at sampling 5Y
Category Cancer cell line
STR profile Source(s): CLS=302006; DSMZ=ACC-757; PubMed=25877200; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO8,10
D2S133821
D3S135816
D5S81812,13
D7S82010,11
D8S117914,15 (CLS=302006; DSMZ=ACC-757; Technion Genomics Center)
15 (PubMed=25877200)
D13S3179,11
D16S5399,11 (DSMZ=ACC-757; PubMed=25877200; Technion Genomics Center)
9,12 (CLS=302006)
D18S5116,21.2 (DSMZ=ACC-757)
16,22 (PubMed=25877200; Technion Genomics Center)
D19S43312,14
D21S1127,28
FGA27 (DSMZ=ACC-757)
27,28 (PubMed=25877200; Technion Genomics Center)
Penta D10,11
Penta E7
TH017
TPOX6,9
vWA14,15 (CLS=302006; DSMZ=ACC-757; Technion Genomics Center)
14,16 (PubMed=25877200)

Run an STR similarity search on this cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/b/cell-lines-detail-73.html
Publications

PubMed=4369887; DOI=10.1073/pnas.71.8.3283; PMCID=PMC388669
George Klein, Tomas Lars Lindahl, Mikael Jondal, Wolfgang Leibold, Jose Menezes, Kenneth Nilsson, Christer Sundstrom;
Continuous lymphoid cell lines with characteristics of B cells (bone-marrow-derived), lacking the Epstein-Barr virus genome and derived from three human lymphomas.
Proc. Natl. Acad. Sci. U.S.A. 71:3283-3286(1974)

PubMed=171663; DOI=10.1073/pnas.72.9.3518; PMCID=PMC433026
Michael Steinitz, George Klein;
Comparison between growth characteristics of an Epstein-Barr virus (EBV)-genome-negative lymphoma line and its EBV-converted subline in vitro.
Proc. Natl. Acad. Sci. U.S.A. 72:3518-3520(1975)

PubMed=179629
Jose Menezes, Wolfgang Leibold, George Klein, Geoffrey Baverstock Clements;
Establishment and characterization of an Epstein-Barr virus (EBV)-negative lymphoblastoid B cell line (BJA-B) from an exceptional, EBV-genome-negative African Burkitt's lymphoma.
Biomedicine 22:276-284(1975)

PubMed=62724; DOI=10.1002/ijc.2910180513
George Klein, Jesper Zeuthen, Paul Ichiro Terasaki, Ronald James Billing, Ron Honig, Mikael Jondal, Anita Westman, Geoffrey Baverstock Clements;
Inducibility of the Epstein-Barr virus (EBV) cycle and surface marker properties of EBV-negative lymphoma lines and their in vitro EBV-converted sublines.
Int. J. Cancer 18:639-652(1976)

PubMed=175026; DOI=10.1002/ijc.2910170203
Karl-Otto Fresen, Harald zur Hausen;
Establishment of EBNA-expressing cell lines by infection of Epstein-Barr virus (EBV)-genome-negative human lymphoma cells with different EBV strains.
Int. J. Cancer 17:161-166(1976)

PubMed=6245632; DOI=10.1007/BF01320759
Sylvia W.-L. Lui, Mun-Hon Ng;
Glycoproteins and sialyl transferase of human B lymphoblastoid cell lines.
Arch. Virol. 63:31-41(1980)

PubMed=7316467; DOI=10.1111/j.1469-1809.1980.tb00953.x
Susan Povey, Stephen Jeremiah, Elizabeth Arthur, Michael Steel, George Klein;
Differences in genetic stability between human cell lines from patients with and without lymphoreticular malignancy.
Ann. Hum. Genet. 44:119-133(1980)

PubMed=6286763; DOI=10.4049/jimmunol.129.3.1336
David Benjamin, Ian Trevor Magrath, Robert T. Maguire, Carol Janus, Heather D. Todd-Kulikowsk, Robert G. Parsons;
Immunoglobulin secretion by cell lines derived from African and American undifferentiated lymphomas of Burkitt's and non-Burkitt's type.
J. Immunol. 129:1336-1342(1982)

PubMed=6600440; DOI=10.1007/BF02617996
Christel H. Uittenbogaart, Yael Cantor, John L. Fahey;
Growth of human malignant lymphoid cell lines in serum-free medium.
In Vitro 19:67-72(1983)

PubMed=6231253; DOI=10.1002/ijc.2910330407
Barbro Ehlin-Henriksson, George Klein;
Distinction between Burkitt lymphoma subgroups by monoclonal antibodies: relationships between antigen expression and type of chromosomal translocation.
Int. J. Cancer 33:459-463(1984)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3495441; DOI=10.1002/eji.1830170503
Susan Kanowith-Klein, Andrew Saxon, Christel H. Uittenbogaart;
Constitutive production of B cell differentiation factor-like activity by human T and B cell lines.
Eur. J. Immunol. 17:593-598(1987)

PubMed=1915267; DOI=10.1002/j.1460-2075.1991.tb07837.x; PMCID=PMC452998
Paul J. Farrell, Gordon J. Allan, Frances Shanahan, Karen Heather Vousden, Tim Crook;
p53 is frequently mutated in Burkitt's lymphoma cell lines.
EMBO J. 10:2879-2887(1991)

PubMed=8344493; DOI=10.1096/fasebj.7.10.8344493
Kishor G. Bhatia, Walter Goldschmidts, Marina I. Gutierrez, Gianluca Gaidano, Riccardo Dalla-Favera, Ian Trevor Magrath;
Hemi- or homozygosity: a requirement for some but not other p53 mutant proteins to accumulate and exert a pathogenetic effect.
FASEB J. 7:951-956(1993)

PubMed=8515068; DOI=10.4049/jimmunol.150.12.5418
Vinay K. Jain, Jean-Gabriel Judde, Edward E. Max, Ian Trevor Magrath;
Variable IgH chain enhancer activity in Burkitt's lymphomas suggests an additional, direct mechanism of c-myc deregulation.
J. Immunol. 150:5418-5428(1993)

PubMed=8558920
Wilhelm Gerhard Dirks, Margarete Zaborski, Kathrin Jager, Cecile Challier, Mami Shiota, Hilmar Quentmeier, Hans Gunther Drexler;
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=20054396; DOI=10.1038/nature08638; PMCID=PMC2845535
R. Eric Davis, Vu N. Ngo, Georg Lenz, Pavel Tolar, Ryan M. Young, Paul Bernard Romesser, Holger Kohlhammer, Laurence Lamy, Hong Zhao, Yan-Dan Yang, Wei-Hong Xu ...Show all 37 authors... , Arthur L. Shaffer 3rd, George Wright, Wen-Ming Xiao, John I. Powell, Jian-Kang Jiang, Craig J. Thomas, Andreas Rosenwald, German Ott, Hans-Konrad Muller-Hermelink, Randy D. Gascoyne, Joseph M. Connors, Nathalie A. Johnson, Lisa M. Rimsza, Elias Campo, Elaine Sarkin Jaffe, Wyndham H. Wilson, Jan Delabie, Erlend Bremertun Smeland, Richard I. Fisher, Rita Merle Braziel, Raymond Roy Tubbs, James R. Cook, Dennis D. Weisenburger, Wing-Chung Chan, Susan Keen Pierce, Louis Michael Staudt; Show fewer authors
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma.
Nature 463:88-92(2010)

PubMed=23257783; DOI=10.1038/leu.2012.367
Soren-Sebastian Wenzel, Michael Grau, Cory Mavis, Stephan Hailfinger, Annette Wolf, Hannelore Madle, George Deeb, Bernd Dorken, Margot Thome, Peter Lenz, Stefan Dirnhofer ...Show all 14 authors... , Francisco Javier Hernandez-Ilizaliturri, Alexandar Tzankov, Georg Lenz; Show fewer authors
MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.
Leukemia 27:1381-1390(2013)

PubMed=23292937; DOI=10.1073/pnas.1205299110; PMCID=PMC3557051
Jenny Zhang, Vladimir Grubor, Cassandra L. Love, Anjishnu Banerjee, Kristy L. Richards, Piotr Andrzej Mieczkowski, Cherie Dunphy, William Wai-Lap Choi, Wing Yan Au, Gopesh Srivastava, Patricia Lynne Lugar ...Show all 36 authors... , David A. Rizzieri, Anand S. Lagoo, Leon Bernal-Mizrachi, Karen P. Mann, Christopher Robert Flowers, Kikkeri N. Naresh, Andrew M. Evens, Leo I. Gordon, Magdalena B. Czader, Javed Iqbal Gill, Eric Darryl Hsi, Qing-Quan Liu, Alice Fan, Katherine Walsh, Dereje Jima, Lisa L. Smith, Amy J. Johnson, John C. Byrd, Micah Alan Luftig, Ting Ni, Jun Zhu, Amy Chadburn, Shawn Levy, David Brian Dunson, Sandeep S. Dave; Show fewer authors
Genetic heterogeneity of diffuse large B-cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=26787899; DOI=10.1073/pnas.1524677113; PMCID=PMC4747717
Joseph D. Dekker, Daechan Park, Arthur L. Shaffer 3rd, Holger Kohlhammer, Wei Deng, Bum-Kyu Lee, Gregory C. Ippolito, George Georgiou, Vishwanath R. Iyer, Louis Michael Staudt, Haley O. Tucker;
Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1.
Proc. Natl. Acad. Sci. U.S.A. 113:E577-E586(2016)

PubMed=29416618; DOI=10.18632/oncotarget.20378; PMCID=PMC5787470
Wei Liu, Juan Chen, Archito T. Tamayo, Chang-Geng Ruan, Li Li, Shou-Hao Zhou, Chan Shen, Ken H. Young, Jason Westin, Richard E. Davis, Shi-Min Hu ...Show all 14 authors... , L. Jeffrey Medeiros, Richard Joseph Ford Jr., Lan V. Pham; Show fewer authors
Preclinical efficacy and biological effects of the oral proteasome inhibitor ixazomib in diffuse large B-cell lymphoma.
Oncotarget 9:346-360(2018)

PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004
Lan V. Pham, Sheng-Jian Huang, Hui Zhang, Jun Zhang, Taylor Bell, Shou-Hao Zhou, Elizabeth Pogue, Zhi-Yong Ding, Laura Lam, Jason Westin, R. Eric Davis ...Show all 17 authors... , Ken H. Young, L. Jeffrey Medeiros, Richard Joseph Ford Jr., Krystle Nomie, Leo Zhang, Michael Wang; Show fewer authors
Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.
Clin. Cancer Res. 24:3967-3980(2018)

PubMed=30165192; DOI=10.1016/j.canlet.2018.08.020
Chang-Ju Qu, Kranthi Kunkalla, Amineh Vaghefi, John K. Frederiksen, Ya-Dong Liu, Jennifer R. Chapman, Marzenna Blonska, Leon Bernal-Mizrachi, Juan Pablo Alderuccio, Izidore S. Lossos, Ralf Landgraf, Francisco Vega-Vazquez;
Smoothened stabilizes and protects TRAF6 from degradation: a novel non-canonical role of smoothened with implications in lymphoma biology.
Cancer Lett. 436:149-158(2018)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

Cross-references
Cell line collections (Providers) AddexBio; C0003016/4884
CLS; 302006
DSMZ; ACC-757
Cell line databases/resources cancercelllines; CVCL_5711
CGH-DB; 9192-4
DSMZCellDive; ACC-757
Lonza; 107
TOKU-E; 3575
Anatomy/cell type resources BTO; BTO_0001931
Biological sample resources BioSample; SAMN03470800
CRISP screens repositories BioGRID_ORCS_Cell_line; 741
Chemistry resources ChEMBL-Cells; CHEMBL3308492
ChEMBL-Targets; CHEMBL613536
PharmacoDB; BJAB_102_2019
PubChem_Cell_line; CVCL_5711
Encyclopedic resources Wikidata; Q50348210
Experimental variables resources EFO; EFO_0002815
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM33155
GEO; GSM710427
GEO; GSM710443
GEO; GSM1059805
GEO; GSM3150240
Polymorphism and mutation databases Cosmic; 998715
Cosmic; 1019312
Cosmic; 1037700
Cosmic; 1086323
Cosmic; 1127265
Cosmic; 1517659
Cosmic; 1588562
Cosmic; 1945179
IARC_TP53; 699
Progenetix; CVCL_5711
Proteomic databases PRIDE; PXD012087
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number45