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Cellosaurus LAPC-4 (CVCL_4744)

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Cell line name LAPC-4
Synonyms LAPC4; Los Angeles Prostate Cancer-4
Accession CVCL_4744
Resource Identification Initiative To cite this cell line use: LAPC-4 (RRID:CVCL_4744)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-1441.
Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (PubMed=21698104; PubMed=21750403).
Doubling time: 60.87 hours (JWGray panel).
Karyotypic information: Has lost chromosome Y.
Omics: Proteomics; PTM; Phosphorylation; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
HLA typing Source: PubMed=25960936
Class I
HLA-AA*01:01,02:01
HLA-BB*14:06,46:01
HLA-CC*05:01,05:01
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4745 (LAPC-4*2)CVCL_RA56 (LAPC-4-EnzR)CVCL_C7X9 (LAPC4-AR)
CVCL_A0BW (LAPC4-CR)CVCL_C0RQ (LAPC4-PDR1)CVCL_WZ26 (LAPC4-SL)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ATCC=CRL-13009; PubMed=11304728; PubMed=14518029

Markers:
AmelogeninX,Y
CSF1PO12,13
D3S135815,17
D5S81811,13 (PubMed=11304728; PubMed=14518029)
12 (ATCC=CRL-13009)
D7S82010,10.3,11 (ATCC=CRL-13009)
11 (PubMed=11304728; PubMed=14518029)
D8S117913
D13S3179,10,11,12 (ATCC=CRL-13009)
10,12 (PubMed=11304728; PubMed=14518029)
D16S5399
D18S5114,15,22
D21S1128,30
FGA21,22
TH016,9.3
TPOX8
vWA15,16 (ATCC=CRL-13009)
16 (PubMed=11304728; PubMed=14518029)

Run an STR similarity search on this cell line
Web pages Info; Wikipedia; -; https://en.wikipedia.org/wiki/LAPC4
Publications

PubMed=9095173; DOI=10.1038/nm0497-402
Karen A. Klein, Robert E. Reiter, James Redula, Hamid Moradi, Xiao-Lin Zhu, Arthur R. Brothman, Dolores J. Lamb, Marco Marcelli, Arie S. Belldegrun, Owen Neil Witte, Charles Lazelle Sawyers;
Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice.
Nat. Med. 3:402-408(1997)

PubMed=10861745; DOI=10.1002/1097-0045(20000601)43:4<263::AID-PROS5>3.0.CO;2-I
Wytske M. van Weerden, Johannes C. Romijn;
Use of nude mouse xenograft models in prostate cancer research.
Prostate 43:263-271(2000)

PubMed=11304728; DOI=10.1002/pros.1045
Adrie van Bokhoven, Marileila Varella-Garcia, Christopher T. Korch, Daphne Hessels, Gary J. Miller;
Widely used prostate carcinoma cell lines share common origins.
Prostate 47:36-51(2001)

Patent=US6365797
Charles Lazelle Sawyers, Karen A. Klein, Owen Neil Witte, Robert E. Reiter;
Mice models of human prostate cancer progression.
Patent number US6365797, 02-Apr-2002

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Pamela J. Russell, Elizabeth A. Kingsley;
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

PubMed=14518029; DOI=10.1002/pros.10290
Adrie van Bokhoven, Marileila Varella-Garcia, Christopher T. Korch, Widya U. Johannes, E. Erin Smith, Heidi L. Miller, Steven K. Nordeen, Gary J. Miller, M. Scott Lucia;
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

PubMed=14518030; DOI=10.1002/pros.10291
Adrie van Bokhoven, Aimee Caires, Michael Di Maria, Aline Passarini Schulte, M. Scott Lucia, Steven K. Nordeen, Gary J. Miller, Marileila Varella-Garcia;
Spectral karyotype (SKY) analysis of human prostate carcinoma cell lines.
Prostate 57:226-244(2003)

CLPUB00698
Adrie van Bokhoven;
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004); Katholieke Universiteit Nijmegen; Nijmegen; Netherlands

PubMed=15486987; DOI=10.1002/pros.20158
Hong-Juan Zhao, Young Kim, Pei Wang, Jacques Lapointe, Robert Tibshirani, Jonathan R. Pollack, James D. Brooks;
Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines.
Prostate 63:187-197(2005)

PubMed=15643173; DOI=10.1097/01.ju.0000149989.01263.dc
Richard E. Sobel, Marianne D. Sadar;
Cell lines used in prostate cancer research: a compendium of old and new lines -- part 2.
J. Urol. 173:360-372(2005)

PubMed=21698104; DOI=10.1371/journal.pone.0020874; PMCID=PMC3117837
Karen Sandell Sfanos, Amanda L. Aloia, Jessica L. Hicks, David M. Esopi, Jared P. Steranka, Wei Shao, Silvia Sanchez-Martinez, Srinivasan Yegnasubramanian, Kathleen H. Burns, Alan Rein, Angelo M. De Marzo;
Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines.
PLoS ONE 6:e20874.1-e20874.6(2011)

PubMed=21750403; DOI=10.4161/cbt.12.7.15955; PMCID=PMC3218386
Yu-An Zhang, Anirban Maitra, Jer-Tsong Hsieh, Charles M. Rudin, Craig Douglas Peacock, Collins Karikari, Rolf A. Brekken, Victor A. Stastny, Bo-Ning Gao, Luc Girard, Ignacio Ivan Wistuba ...Show all 14 authors... , Eugene Philip Frenkel, John D. Minna, Adi F. Gazdar; Show fewer authors
Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts.
Cancer Biol. Ther. 12:617-628(2011)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=28145883; DOI=10.18632/oncotarget.14850; PMCID=PMC5386661
Mannan Nouri, Josselin Caradec, Amy Anne Lubik, Na Li, Brett G. Hollier, Mandeep Takhar, Manuel Altimirano-Dimas, Meng-Qian Chen, Mani Roshan-Moniri, Miriam Butler, Melanie Lehman ...Show all 27 authors... , Jennifer L. Bishop, Sarah Truong, Shih-Chieh Huang, Dawn R. Cochrane, Michael Cox, Catherine Collins, Martin E. Gleave, Nicholas Erho, Mohamed Alshalafa, Elai Davicioni, Colleen Nelson, Cheryl Y. Gregory-Evans, R. Jeffrey Karnes, Robert Brian Jenkins, Eric A. Klein, Ralph Buttyan; Show fewer authors
Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance.
Oncotarget 8:18949-18967(2017)

PubMed=29194687; DOI=10.1002/pros.23459; PMCID=PMC5768451
Michael V. Fiandalo, John H. Wilton, Krystin M. Mantione, Carol Wrzosek, Kristopher M. Attwood, Yue Wu, James Larue Mohler;
Serum-free complete medium, an alternative medium to mimic androgen deprivation in human prostate cancer cell line models.
Prostate 78:213-221(2018)

PubMed=29739788; DOI=10.1158/1078-0432.CCR-18-0410; PMCID=PMC6125187
Renee de Leeuw, Christopher McNair, Matthew J. Schiewer, Neermala Poudel-Neupane, Lucas J. Brand, Michael A. Augello, Zhen Li, Larry C. Cheng, Akihiro Yoshida, Sean M. Courtney, Edward Starr Hazard ...Show all 17 authors... , Gary Hardiman, Maha H. Hussain, John Alan Diehl, Justin M. Drake, William Kevin Kelly, Karen E. Knudsen; Show fewer authors
MAPK reliance via acquired CDK4/6 inhibitor resistance in cancer.
Clin. Cancer Res. 24:4201-4214(2018)

PubMed=34402095; DOI=10.1002/pros.24210; PMCID=PMC8460612
Michael C. Haffner, Akshay Bhamidipati, Harrison K. Tsai, David M. Esopi, Ajay M. Vaghasia, Jin-Yih Low, Radhika A. Patel, Gunes Guner, Minh-Tam Pham, Nicole Castagna, Jessica L. Hicks ...Show all 17 authors... , Nicolas Wyhs, Rudolf Aebersold, Angelo M. De Marzo, William George Nelson, Tian-Nan Guo, Srinivasan Yegnasubramanian; Show fewer authors
Phenotypic characterization of two novel cell line models of castration-resistant prostate cancer.
Prostate 81:1159-1171(2021)

Cross-references
Cell line collections (Providers) ATCC; CRL-13009 - Discontinued
Cell line databases/resources cancercelllines; CVCL_4744
Anatomy/cell type resources BTO; BTO_0002997
Biological sample resources BioSample; SAMN03471350
Chemistry resources ChEMBL-Cells; CHEMBL3308023
ChEMBL-Targets; CHEMBL613292
PubChem_Cell_line; CVCL_4744
Encyclopedic resources Wikidata; Q29565860
Experimental variables resources EFO; EFO_0005392
Gene expression databases GEO; GSM91931
GEO; GSM648820
GEO; GSM1374616
GEO; GSM1633305
GEO; GSM1633306
GEO; GSM1633307
GEO; GSM2069506
GEO; GSM2069507
GEO; GSM2069508
GEO; GSM2069509
GEO; GSM2069510
GEO; GSM2069511
GEO; GSM2069512
GEO; GSM2069513
GEO; GSM2649999
GEO; GSM2650000
GEO; GSM2650001
GEO; GSM2650002
GEO; GSM2650003
GEO; GSM2650004
GEO; GSM3145593
GEO; GSM3145715
GEO; GSM5402198
Polymorphism and mutation databases Cosmic; 1330913
Cosmic; 1689711
Cosmic; 2537793
Cosmic; 2580299
IARC_TP53; 18889
Progenetix; CVCL_4744
Proteomic databases PRIDE; PXD006561
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number37