Cellosaurus cell line LAPC4-PDR1 (CVCL

Cellosaurus LAPC4-PDR1 (CVCL_C0RQ)

Cross-references
Cell line name	LAPC4-PDR1
Synonyms	LAPC4 PDR1; L4-PDR1
Accession	CVCL_C0RQ
Resource Identification Initiative	To cite this cell line use: LAPC4-PDR1 (RRID:CVCL_C0RQ)
Comments	Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (from parent cell line). Selected for resistance to: ChEBI; CHEBI_85993; Palbociclib (Ibrance). Omics: Proteomics; PTM; Phosphorylation; Quantitative. Omics: Transcriptomics; RNAseq. Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (from parent cell line).
Disease	Prostate carcinoma (NCIt: C4863)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_4744 (LAPC-4)
Sex of cell	Male
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=29739788; DOI=10.1158/1078-0432.CCR-18-0410; PMCID=PMC6125187 Renee de Leeuw, Christopher McNair, Matthew J. Schiewer, Neermala Poudel-Neupane, Lucas J. Brand, Michael A. Augello, Zhen Li, Larry C. Cheng, Akihiro Yoshida, Sean M. Courtney, Edward Starr Hazard ...Show all 17 authors... , Gary Hardiman, Maha H. Hussain, John Alan Diehl, Justin M. Drake, William Kevin Kelly, Karen E. Knudsen; Show fewer authors MAPK reliance via acquired CDK4/6 inhibitor resistance in cancer. Clin. Cancer Res. 24:4201-4214(2018)
Cell line databases/resources	cancercelllines; CVCL_C0RQ
Encyclopedic resources	Wikidata; Q112929984
Gene expression databases	GEO; GSM2649993 GEO; GSM2649994 GEO; GSM2649995 GEO; GSM2649996 GEO; GSM2649997 GEO; GSM2649998
Proteomic databases	PRIDE; PXD006561
Entry history
Entry creation	23-Jun-2022
Last entry update	10-Apr-2025
Version number	9