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Cellosaurus LAPC-4-EnzR (CVCL_RA56)

[Text version]
Cell line name LAPC-4-EnzR
Accession CVCL_RA56
Resource Identification Initiative To cite this cell line use: LAPC-4-EnzR (RRID:CVCL_RA56)
Comments Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (from parent cell line).
Selected for resistance to: ChEBI; CHEBI_68534; Enzalutamide (Xtandi; MDV-3100).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4744 (LAPC-4)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=27036029; DOI=10.18632/oncotarget.8456; PMCID=PMC5041979
Steven Kregel, James L. Chen, Westin Tom, Venkatesh Krishnan, Jacob Kach, Hannah Brechka, Tim B. Fessenden, Masis Isikbay, Gladell Pador Paner, Russell Z. Szmulewitz, Donald J. Vander Griend;
Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer.
Oncotarget 7:26259-26274(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RA56
Encyclopedic resources Wikidata; Q54901926
Gene expression databases GEO; GSM2069514
GEO; GSM2069515
GEO; GSM2069516
GEO; GSM2069517
Entry history
Entry creation05-Mar-2018
Last entry update10-Apr-2025
Version number13