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Cellosaurus COLO 849 (CVCL_2002)

[Text version]
Cell line name COLO 849
Synonyms COLO-849; Colo 849; COLO #849; COLO849; Colorado 849
Accession CVCL_2002
Resource Identification Initiative To cite this cell line use: COLO 849 (RRID:CVCL_2002)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: ~50-60 hours (DSMZ=ACC-216).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Right axillary lymph node; UBERON=UBERON_0001097.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,03:01
HLA-BB*08:01,40:02
HLA-CC*03:04,07:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.07
East Asian, North2.02
East Asian, South0
South Asian0
European, North73.1
European, South24.82
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1137 ! COLO 829
CVCL_1999 ! COLO 829BL
CVCL_L503 ! COLO 831
CVCL_2000 ! COLO 832
CVCL_L504 ! COLO 833
CVCL_L505 ! COLO 834
CVCL_L506 ! COLO 835
CVCL_L507 ! COLO 838
CVCL_2001 ! COLO 839
CVCL_L508 ! COLO 845
CVCL_L509 ! COLO 848
CVCL_2003 ! COLO 853
CVCL_2004 ! COLO 857
CVCL_2005 ! COLO 858
Sex of cell Male
Age at sampling 43Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-216; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11
D2S133818,26
D3S135816,18
D5S81811
D7S8208,10
D8S117913,14 (PubMed=25877200)
13,16 (DSMZ=ACC-216)
D13S31711,12
D16S53913
D18S5115
D19S43314,15
D21S1127,29
FGA21,25
Penta D9,14
Penta E7,12
TH0110
TPOX8,11
vWA19

Run an STR similarity search on this cell line
Publications

PubMed=8402545; DOI=10.1016/0165-4608(93)90083-X
Helvise G. Morse, George Eugene Moore;
Cytogenetic homogeneity in eight independent sites in a case of malignant melanoma.
Cancer Genet. Cytogenet. 69:108-112(1993)

PubMed=7780963
David J. Easty, Brenda A. Guthrie, Kavita Maung, Christine J. Farr, Richard A. Lindberg, Robert J. Toso, Meenhard Herlyn, Dorothy Catherine Bennett;
Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression.
Cancer Res. 55:2528-2532(1995)

PubMed=11668190; DOI=10.1177/002215540104901105
Hilmar Quentmeier, Mary Osborn, Julia Reinhardt, Margarete Zaborski, Hans Gunther Drexler;
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-216
Cell line databases/resources CLO; CLO_0002578
CLDB; cl872
cancercelllines; CVCL_2002
Cell_Model_Passport; SIDM01870
DepMap; ACH-001045
DSMZCellDive; ACC-216
LINCS_LDP; LCL-1245
Biological sample resources BioSample; SAMN03473234
Chemistry resources PharmacoDB; COLO849_239_2019
Encyclopedic resources Wikidata; Q54814168
Experimental variables resources EFO; EFO_0006379
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM886954
GEO; GSM888022
Polymorphism and mutation databases Cosmic; 888062
IARC_TP53; 21247
Progenetix; CVCL_2002
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number33