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Cellosaurus COLO 829 (CVCL_1137)

[Text version]
Cell line name COLO 829
Synonyms COLO-829; Colo-829; Colo 829; COLO #829; COLO829; Colo829; Colorado 829
Accession CVCL_1137
Resource Identification Initiative To cite this cell line use: COLO 829 (RRID:CVCL_1137)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Characteristics: Single cell sequencing has shown that it is composed of four major sub-clones (PubMed=32587328).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Genome sequenced.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Single cell genome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=12068308; PubMed=27094764; ATCC=CRL-1974; Cosmic-CLP=687448; DepMap=ACH-000644).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Ala68Glyfs*51 (c.203_204delCG); Zygosity=Homozygous (PubMed=27094764; ATCC=CRL-1974).
  • Mutation; HGNC; 9588; PTEN; Simple; c.493_634del142; Zygosity=Homozygous (ATCC=CRL-1974).
  • Mutation; HGNC; 11730; TERT; Simple; c.228_229CC>TT (-124/-125CC>TT); Zygosity=Unspecified; Note=In promoter (PubMed=31068700).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,01:01
HLA-BB*08:01,40:02
HLA-CC*03:04,07:06
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.12
Native American0
East Asian, North2.63
East Asian, South0
South Asian0
European, North71.18
European, South26.07
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_IW11 (Colo829/R)
Originate from same individual CVCL_1999 ! COLO 829BL
CVCL_L503 ! COLO 831
CVCL_2000 ! COLO 832
CVCL_L504 ! COLO 833
CVCL_L505 ! COLO 834
CVCL_L506 ! COLO 835
CVCL_L507 ! COLO 838
CVCL_2001 ! COLO 839
CVCL_L508 ! COLO 845
CVCL_L509 ! COLO 848
CVCL_2002 ! COLO 849
CVCL_2003 ! COLO 853
CVCL_2004 ! COLO 857
CVCL_2005 ! COLO 858
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1974; Cosmic-CLP=687448; DepMap=ACH-000644; IZSLER=BS TCL 198; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11
D2S133818,26
D3S135816,18
D5S81811
D7S8208,10
D8S117913,14
D13S31711,12
D16S53913
D18S5115
D19S43314,15
D21S1127,29
FGA21,25
Penta D9,14
Penta E7,12
TH0110
TPOX8,11
vWA17,19

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
http://genome.ucsc.edu/ENCODE/protocols/cell/human/Colo829_Crawford_protocol.pdf
https://www.cellosaurus.org/pawefish/OtherCellLineDescriptions/COLO829.html
Publications

PubMed=7780963
Easty D.J., Guthrie B.A., Maung K., Farr C.J., Lindberg R.A., Toso R.J., Herlyn M., Bennett D.C.
Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression.
Cancer Res. 55:2528-2532(1995)

PubMed=12068308; DOI=10.1038/nature00766
Davies H., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=14762065; DOI=10.1101/gr.2012304
Bignell G.R., Huang J., Greshock J., Watt S., Butler A.P., West S., Grigorova M., Jones K.W., Wei W., Stratton M.R., Futreal P.A., Weber B., Shapero M.H., Wooster R.
High-resolution analysis of DNA copy number using oligonucleotide microarrays.
Genome Res. 14:287-295(2004)

PubMed=18698037; DOI=10.1158/1078-0432.CCR-08-0186
Reschke M., Mihic-Probst D., van der Horst E.H., Knyazev P., Wild P.J., Hutterer M., Meyer S., Dummer R., Moch H., Ullrich A.
HER3 is a determinant for poor prognosis in melanoma.
Clin. Cancer Res. 14:5188-5197(2008)

PubMed=20016485; DOI=10.1038/nature08658
Pleasance E.D., Cheetham R.K., Stephens P.J., McBride D.J., Humphray S.J., Greenman C.D., Varela I., Lin M.-L., Ordonez G.R., Bignell G.R., Ye K., Alipaz J.A., Bauer M.J., Beare D., Butler A.P., Carter R.J., Chen L., Cox A.J., Edkins S., Kokko-Gonzales P.I., Gormley N.A., Grocock R.J., Haudenschild C.D., Hims M.M., James T., Jia M.-M., Kingsbury Z., Leroy C., Marshall J., Menzies A., Mudie L.J., Ning Z.-M., Royce T., Schulz-Trieglaff O.B., Spiridou A., Stebbings L.A., Szajkowski L., Teague J.W., Williamson D., Chin L., Ross M.T., Campbell P.J., Bentley D.R., Futreal P.A., Stratton M.R.
A comprehensive catalogue of somatic mutations from a human cancer genome.
Nature 463:191-196(2010)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23285177; DOI=10.1371/journal.pone.0052760
Schayowitz A.B., Bertenshaw G.P., Jeffries E., Schatz T., Cotton J., Villanueva J., Herlyn M., Krepler C., Vultur A., Xu W., Yu G.H., Schuchter L.M., Clark D.P.
Functional profiling of live melanoma samples using a novel automated platform.
PLoS ONE 7:E52760-E52760(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27094764; DOI=10.1038/srep24607
Craig D.W., Nasser S., Corbett R., Chan S.K., Murray L., Legendre C., Tembe W., Adkins J., Kim N., Wong S.-M., Baker A., Enriquez D., Pond S., Pleasance E.D., Mungall A.J., Moore R.A., McDaniel T., Ma Y., Jones S.J.M., Marra M.A., Carpten J.D., Liang W.S.
A somatic reference standard for cancer genome sequencing.
Sci. Rep. 6:24607-24607(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=32587328; DOI=10.1038/s42003-020-1044-8
Velazquez-Villarreal E.I., Maheshwari S., Sorenson J., Fiddes I.T., Kumar V., Yin Y.-F., Webb M.G., Catalanotti C., Grigorova M., Edwards P.A.W., Carpten J.D., Craig D.W.
Single-cell sequencing of genomic DNA resolves sub-clonal heterogeneity in a melanoma cell line.
Commun. Biol. 3:318.1-318.8(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-1974
ECACC; 93052611 - Discontinued
IZSLER; BS TCL 198
Cell line databases/resources CLO; CLO_0002563
CLO; CLO_0037123
CLDB; cl856
cancercelllines; CVCL_1137
Cell_Model_Passport; SIDM00909
Cosmic-CLP; 687448
DepMap; ACH-000644
IGRhCellID; COLO829
LINCS_LDP; LCL-1269
Biological sample resources BioSample; SAMN03470888
BioSample; SAMN10988208
ENCODE; ENCBS172AAA
Chemistry resources ChEMBL-Cells; CHEMBL3308286
ChEMBL-Targets; CHEMBL2366275
GDSC; 687448
PharmacoDB; COLO829_238_2019
PubChem_Cell_line; CVCL_1137
Encyclopedic resources Wikidata; Q54814157
Experimental variables resources EFO; EFO_0002140
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSE151409
GEO; GSM206465
GEO; GSM274683
GEO; GSM886953
GEO; GSM888021
GEO; GSM1008571
GEO; GSM1178047
GEO; GSM1178048
GEO; GSM1669695
Polymorphism and mutation databases Cosmic; 687448
Cosmic; 965553
Cosmic; 1459644
Cosmic; 1477404
Cosmic; 1995376
Cosmic; 2159430
IARC_TP53; 21246
LiGeA; CCLE_650
Progenetix; CVCL_1137
Proteomic databases PRIDE; PXD030304
Sequence databases dbGAP; phs001839.v1.p1
EGA; EGAS00000000052
EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number41