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Cellosaurus SH-EP (CVCL_0524)

[Text version]

Cell line name SH-EP
Synonyms SHEP
Accession CVCL_0524
Resource Identification Initiative To cite this cell line use: SH-EP (RRID:CVCL_0524)
Comments Population: Caucasian.
Sequence variations
  • Mutation; HGNC; 427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0531 (SK-N-SH)
Children:
CVCL_VL18 (MYCN-2 Tet-on )CVCL_VL19 (MYCN-3 Tet-on )CVCL_0522 (SH-EP007 )
CVCL_0F47 (SH-EP1 )CVCL_2A38 (SHEP-SF )CVCL_EI12 (SHEP-TR-miR-17-92 )
CVCL_RR78 (SHEPrCDDP1000 )CVCL_RS82 (SHEPrDOX100 )CVCL_RR79 (SHEPrETO100 )
CVCL_RS18 (SHEPrSNS-032_2000nM )CVCL_RR80 (SHEPrVCR1 )CVCL_RS83 (SHEPrVCR10 )
CVCL_RS84 (SHEPrVCR20 )
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/s/cell-lines-detail-530.html
Publications

PubMed=6137586; DOI=10.1093/jnci/71.4.741
Ross R.A., Spengler B.A., Biedler J.L.
Coordinate morphological and biochemical interconversion of human neuroblastoma cells.
J. Natl. Cancer Inst. 71:741-747(1983)

PubMed=2535691
Ciccarone V., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A.
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Cancer Res. 49:219-225(1989)

PubMed=1354203; DOI=10.1002/ijc.2910520116
Gross N., Favre S., Beck D., Meyer M.
Differentiation-related expression of adhesion molecules and receptors on human neuroblastoma tissues, cell lines and variants.
Int. J. Cancer 52:85-91(1992)

PubMed=24466371; DOI=10.1593/tlo.13544
Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J., Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A., Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=27517323; DOI=10.18632/oncotarget.11160
Loschmann N., Michaelis M., Rothweiler F., Voges Y., Balonova B., Blight B.A., Cinatl J. Jr.
ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance.
Oncotarget 7:58051-58064(2016)

Cross-references
Cell line databases/resources MCCL; MCC:0000423
Anatomy/cell type resources BTO; BTO:0005397
Encyclopedic resources Wikidata; Q54953212
Experimental variables resources EFO; EFO_0006294
Gene expression databases GEO; GSM1622295
Polymorphism and mutation databases Cosmic; 1212535
Cosmic; 2393640
IARC_TP53; 23600
Progenetix; CVCL_0524
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number26