Cellosaurus cell line SH-EP (CVCL

Cellosaurus SH-EP (CVCL_0524)

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Cell line name

SH-EP

Synonyms

SHEP

Accession

CVCL_0524

Resource Identification Initiative

To cite this cell line use: SH-EP (RRID:CVCL_0524)

Comments

Population: Caucasian.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.

Sequence variations

Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).

Disease

Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0531 (SK-N-SH)
Children:

CVCL_VL18 (MYCN-2 Tet-on)	CVCL_VL19 (MYCN-3 Tet-on)	CVCL_0522 (SH-EP007)
CVCL_0F47 (SH-EP1)	CVCL_2A38 (SHEP-SF)	CVCL_EI12 (SHEP-TR-miR-17-92)
CVCL_RR78 (SHEPrCDDP1000)	CVCL_RS82 (SHEPrDOX100)	CVCL_RR79 (SHEPrETO100)
CVCL_RS18 (SHEPrSNS-032_2000nM)	CVCL_RR80 (SHEPrVCR1)	CVCL_RS83 (SHEPrVCR10)
CVCL_RS84 (SHEPrVCR20)

Sex of cell

Female

Age at sampling

Category

Cancer cell line

Web pages

Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/s/cell-lines-detail-530.html

Publications

PubMed=6137586; DOI=10.1093/jnci/71.4.741
Robert A. Ross, Barbara A. Spengler, June Lee Biedler;
Coordinate morphological and biochemical interconversion of human neuroblastoma cells.
J. Natl. Cancer Inst. 71:741-747(1983)

PubMed=2535691
Valentina C. Ciccarone, Barbara A. Spengler, Marian B. Meyers, June Lee Biedler, Robert A. Ross;
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Cancer Res. 49:219-225(1989)

PubMed=1354203; DOI=10.1002/ijc.2910520116
Nicole Gross, Simone Favre, Daniel Beck, Manuela Meyer;
Differentiation-related expression of adhesion molecules and receptors on human neuroblastoma tissues, cell lines and variants.
Int. J. Cancer 52:85-91(1992)

PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703
Nadine Loschmann, Martin Michaelis, Florian Rothweiler, Richard Zehner, Jaroslaw Cinatl, Yvonne Voges, Mohsen Sharifi, Kristoffer Riecken, Jochen Meyer, Andreas von Deimling, Iduna Fichtner ...Show all 14 authors... , Taravat Ghafourian, Frank Westermann, Jindrich Cinatl Jr.; Show fewer authors
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=27517323; DOI=10.18632/oncotarget.11160; PMCID=PMC5295411
Nadine Loschmann, Martin Michaelis, Florian Rothweiler, Yvonne Voges, Barbora Balonova, Barry A. Blight, Jindrich Cinatl Jr.;
ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance.
Oncotarget 7:58051-58064(2016)

Cross-references

Cell line databases/resources

MCCL; MCC:0000423
cancercelllines; CVCL_0524

Anatomy/cell type resources

BTO; BTO_0005397

Encyclopedic resources

Wikidata; Q54953212

Experimental variables resources

EFO; EFO_0006294

Gene expression databases

GEO; GSM1622295

Polymorphism and mutation databases