ID   SH-EP
AC   CVCL_0524
SY   SHEP
DR   BTO; BTO_0005397
DR   EFO; EFO_0006294
DR   MCCL; MCC:0000423
DR   cancercelllines; CVCL_0524
DR   Cosmic; 1212535
DR   Cosmic; 2393640
DR   GEO; GSM1622295
DR   IARC_TP53; 23600
DR   Progenetix; CVCL_0524
DR   Wikidata; Q54953212
RX   PubMed=1354203;
RX   PubMed=2535691;
RX   PubMed=6137586;
RX   PubMed=24466371;
RX   PubMed=27517323;
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/s/cell-lines-detail-530.html
CC   Population: Caucasian.
CC   Doubling time: 17.9 +- 1.4 hours (PubMed=27517323).
CC   Sequence variation: Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0531 ! SK-N-SH
SX   Female
AG   4Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 27-11-25; Version: 32
CH   CVCL_VL18 ! MYCN-2 Tet-on
CH   CVCL_VL19 ! MYCN-3 Tet-on
CH   CVCL_0522 ! SH-EP007
CH   CVCL_0F47 ! SH-EP1
CH   CVCL_2A38 ! SHEP-SF
CH   CVCL_EI12 ! SHEP-TR-miR-17-92
CH   CVCL_RR78 ! SHEPrCDDP1000
CH   CVCL_RS82 ! SHEPrDOX100
CH   CVCL_RR79 ! SHEPrETO100
CH   CVCL_RS18 ! SHEPrSNS-032_2000nM
CH   CVCL_RR80 ! SHEPrVCR1
CH   CVCL_RS83 ! SHEPrVCR10
CH   CVCL_RS84 ! SHEPrVCR20
//
RX   PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703;
RA   Loschmann, Nadine
RA   Michaelis, Martin
RA   Rothweiler, Florian
RA   Zehner, Richard
RA   Cinatl, Jaroslaw
RA   Voges, Yvonne
RA   Sharifi, Mohsen
RA   Riecken, Kristoffer
RA   Meyer, Jochen
RA   von Deimling, Andreas
RA   Fichtner, Iduna
RA   Ghafourian, Taravat
RA   Westermann, Frank
RA   Cinatl, Jindrich Jr.
RT   "Testing of SNS-032 in a panel of human neuroblastoma cell lines with
RT   acquired resistance to a broad range of drugs.";
RL   Transl. Oncol. 6:685-696(2013).
//
RX   PubMed=27517323; DOI=10.18632/oncotarget.11160; PMCID=PMC5295411;
RA   Loschmann, Nadine
RA   Michaelis, Martin
RA   Rothweiler, Florian
RA   Voges, Yvonne
RA   Balonova, Barbora
RA   Blight, Barry A.
RA   Cinatl, Jindrich Jr.
RT   "ABCB1 as predominant resistance mechanism in cells with acquired
RT   SNS-032 resistance.";
RL   Oncotarget 7:58051-58064(2016).
//
RX   PubMed=2535691;
RA   Ciccarone, Valentina C.
RA   Spengler, Barbara A.
RA   Meyers, Marian B.
RA   Biedler, June Lee
RA   Ross, Robert A.
RT   "Phenotypic diversification in human neuroblastoma cells: expression
RT   of distinct neural crest lineages.";
RL   Cancer Res. 49:219-225(1989).
//
RX   PubMed=1354203; DOI=10.1002/ijc.2910520116;
RA   Gross, Nicole
RA   Favre, Simone
RA   Beck, Daniel
RA   Meyer, Manuela
RT   "Differentiation-related expression of adhesion molecules and
RT   receptors on human neuroblastoma tissues, cell lines and variants.";
RL   Int. J. Cancer 52:85-91(1992).
//
RX   PubMed=6137586; DOI=10.1093/jnci/71.4.741;
RA   Ross, Robert A.
RA   Spengler, Barbara A.
RA   Biedler, June Lee
RT   "Coordinate morphological and biochemical interconversion of human
RT   neuroblastoma cells.";
RL   J. Natl. Cancer Inst. 71:741-747(1983).
//