AC   CVCL_0524
DR   BTO; BTO:0005397
DR   EFO; EFO_0006294
DR   MCCL; MCC:0000423
DR   cancercelllines; CVCL_0524
DR   Cosmic; 1212535
DR   Cosmic; 2393640
DR   GEO; GSM1622295
DR   IARC_TP53; 23600
DR   Progenetix; CVCL_0524
DR   Wikidata; Q54953212
RX   PubMed=1354203;
RX   PubMed=2535691;
RX   PubMed=6137586;
RX   PubMed=24466371;
RX   PubMed=27517323;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0531 ! SK-N-SH
SX   Female
AG   4Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 29
RX   PubMed=1354203; DOI=10.1002/ijc.2910520116;
RA   Gross N., Favre S., Beck D., Meyer M.;
RT   "Differentiation-related expression of adhesion molecules and
RT   receptors on human neuroblastoma tissues, cell lines and variants.";
RL   Int. J. Cancer 52:85-91(1992).
RX   PubMed=2535691;
RA   Ciccarone V., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A.;
RT   "Phenotypic diversification in human neuroblastoma cells: expression
RT   of distinct neural crest lineages.";
RL   Cancer Res. 49:219-225(1989).
RX   PubMed=6137586; DOI=10.1093/jnci/71.4.741;
RA   Ross R.A., Spengler B.A., Biedler J.L.;
RT   "Coordinate morphological and biochemical interconversion of human
RT   neuroblastoma cells.";
RL   J. Natl. Cancer Inst. 71:741-747(1983).
RX   PubMed=24466371; DOI=10.1593/tlo.13544;
RA   Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J.,
RA   Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A.,
RA   Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.;
RT   "Testing of SNS-032 in a panel of human neuroblastoma cell lines with
RT   acquired resistance to a broad range of drugs.";
RL   Transl. Oncol. 6:685-696(2013).
RX   PubMed=27517323; DOI=10.18632/oncotarget.11160;
RA   Loschmann N., Michaelis M., Rothweiler F., Voges Y., Balonova B.,
RA   Blight B.A., Cinatl J. Jr.;
RT   "ABCB1 as predominant resistance mechanism in cells with acquired
RT   SNS-032 resistance.";
RL   Oncotarget 7:58051-58064(2016).