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Cellosaurus SK-N-SH (CVCL_0531)

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Cell line name SK-N-SH
Synonyms SK N SH; SKN-SH; SK-NSH; SKNSH; NSH
Accession CVCL_0531
Resource Identification Initiative To cite this cell line use: SK-N-SH (RRID:CVCL_0531)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK1980-529.
Population: Caucasian.
Doubling time: 44 hours (PubMed=4748425).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; ChIP-seq.
Omics: Genomics; Chromatin accessibility; ATAC-seq.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Misspelling: SK-N-CH; Note=Occasionally.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Heterozygous (PubMed=18724359; PubMed=18923523; PubMed=28350380; Cosmic-CLP=717431; DepMap=ACH-000149).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (Cosmic-CLP=717431; DepMap=ACH-000149).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*01:01,24:02
HLA-BB*18:01,49:01
HLA-CC*07:06,07:06

Source: PubMed=26589293
Class I
HLA-AA*01:01,24:02
HLA-BB*18:01,49:01
HLA-CC*07:06,07:06
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.37
Native American0.07
East Asian, North1.63
East Asian, South0
South Asian0
European, North66.77
European, South31.16
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_0524 (SH-EP)CVCL_IY16 (SH-F)CVCL_W973 (SH-FE)
CVCL_W974 (SH-IN)CVCL_IY17 (SH-N)CVCL_0019 (SH-SY5Y)
CVCL_B0GN (SK-N-SH D)CVCL_D044 (SK-N-SH-RA)CVCL_E1CA (Ubigene SK-N-SH CAPNS1 KO)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0005006/4924; ATCC=HTB-11; CCRID; Cosmic-CLP=717431; ECACC=86012802; KCLB=30011; PubMed=25877200; RCB=RCB0426; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO11
D1S165612
D2S44111,11.3
D2S133817,19
D3S135815,16
D5S81812
D7S8207,10
D8S117915
D10S124814
D12S39118,22
D13S31711
D16S5398,13
D18S5113,16
D19S43313,14
D21S1131,31.2
D22S104516,17
FGA23.2,24
Penta D10,12
Penta E7,11
TH017,10
TPOX8,11
vWA14,18

Run an STR similarity search on this cell line
Web pages Info; ENCODE; -; http://genome.ucsc.edu/ENCODE/protocols/cell/human/SK-N-SH_Myers_protocol.pdf
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/s/cell-lines-detail-398.html
Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/human-neuroblastoma-cell-line-sk-n-sh
Publications

PubMed=4748425
June Lee Biedler, Lawrence Helson, Barbara A. Spengler;
Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture.
Cancer Res. 33:2643-2652(1973)

DOI=10.1007/978-1-4757-1647-4_13
June Lee Biedler;
Chromosome abnormalities in human tumor cells in culture.
(In book chapter) Human tumor cells in vitro; Fogh, Jorgen (eds.); pp.359-394; Springer; New York; USA (1975)

PubMed=62055; DOI=10.1093/jnci/57.3.683
June Lee Biedler, Barbara A. Spengler;
A novel chromosome abnormality in human neuroblastoma and antifolate-resistant Chinese hamster cell lives in culture.
J. Natl. Cancer Inst. 57:683-695(1976)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=922665; DOI=10.1002/1097-0142(197711)40:5<2256::AID-CNCR2820400536>3.0.CO;2-1
Garrett M. Brodeur, Gurbax Singh Sekhon, Milton N. Goldstein;
Chromosomal aberrations in human neuroblastomas.
Cancer 40:2256-2263(1977)

PubMed=29704
June Lee Biedler, Suzanne Roffler-Tarlov, Melitta Schachner, Lewis S. Freedman;
Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones.
Cancer Res. 38:3751-3757(1978)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
William C. Wright, Walter P. Daniels, Jorgen Fogh;
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=7037175
Charles Patrick Reynolds, Debra A. Reynolds, Eugene Philip Frenkel, R. Graham Smith;
Selective toxicity of 6-hydroxydopamine and ascorbate for human neuroblastoma in vitro: a model for clearing marrow prior to autologous transplant.
Cancer Res. 42:1331-1336(1982)

DOI=10.1016/B978-0-12-008304-6.50015-4
June Lee Biedler, Marian B. Meyers, Barbara A. Spengler;
Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.
(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff, Sergey & Hertz, Leif (eds.); pp.267-307; Academic Press; New York; USA (1983)

DOI=10.1159/000407025
Lawrence Helson, Mukesh Verma, Christiane Helson;
Vitamin E and human neuroblastoma.
(In book chapter) Modulation and mediation of cancer by vitamins; Meyskens, Frank L. Jr. & Prasad, Kedar N. (eds.); pp.258-265; Karger; Basel; Switzerland (1983)

PubMed=6888561; DOI=10.1038/305245a0
Manfred Schwab, Kari Alitalo, Karl-Heinz Klempnauer, Harold Eliot Varmus, John Michael Bishop, Fred Gilbert, Garrett M. Brodeur, Milton N. Goldstein, Jeffrey M. Trent;
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.
Nature 305:245-248(1983)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=6610792; DOI=10.1093/jnci/73.1.51
Tohru Sugimoto, Eiji Tatsumi, John T. Kemshead, Lawrence Helson, Alexander A. Green, Jun Minowada;
Determination of cell surface membrane antigens common to both human neuroblastoma and leukemia-lymphoma cell lines by a panel of 38 monoclonal antibodies.
J. Natl. Cancer Inst. 73:51-57(1984)

PubMed=2987426; DOI=10.1007/BF00165170
Lawrence Helson, Christiane Helson;
Human neuroblastoma cells and 13-cis-retinoic acid.
J. Neurooncol. 3:39-41(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=2846152
Peter N. Preis, Hideyuki Saya, Laszlo Nadasdi, Guenther Hochhaus, Victor Alan Levin, Wolfgang Sadee;
Neuronal cell differentiation of human neuroblastoma cells by retinoic acid plus herbimycin A.
Cancer Res. 48:6530-6534(1988)

PubMed=2535691
Valentina C. Ciccarone, Barbara A. Spengler, Marian B. Meyers, June Lee Biedler, Robert A. Ross;
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Cancer Res. 49:219-225(1989)

PubMed=1354203; DOI=10.1002/ijc.2910520116
Nicole Gross, Simone Favre, Daniel Beck, Manuela Meyer;
Differentiation-related expression of adhesion molecules and receptors on human neuroblastoma tissues, cell lines and variants.
Int. J. Cancer 52:85-91(1992)

PubMed=8490657; DOI=10.1038/ng0193-62
Inge The, Anita E. Murthy, Gregory E. Hannigan, Lee B. Jacoby, Anil G. Menon, James Francis Gusella, Andre Bernards;
Neurofibromatosis type 1 gene mutations in neuroblastoma.
Nat. Genet. 3:62-66(1993)

DOI=10.1016/B978-0-12-333530-2.50006-X
Mark A. Israel, Carol Jeanne Thiele;
Tumor cell lines of the peripheral nervous system.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.43-78; Academic Press; New York; USA (1994)

PubMed=8040301; DOI=10.1172/JCI117360; PMCID=PMC295111
Marco Giovannini, Jaclyn A. Biegel, Massimo Serra, Jian-Ying Wang, Ya-Lin H. Wei, Lynn M. Nycum, Beverly S. Emanuel, Glen A. Evans;
EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations.
J. Clin. Invest. 94:489-496(1994)

PubMed=8069455; DOI=10.1007/BF02631450
Ken-ichiro Fukuchi, Mark G. Hearn, Samir S. Deeb, Annette C. Smith, Dang Ngoc Thao, Jun-ichi Miyazaki, Mark Bothwell, George M. Martin;
Activity assays of nine heterogeneous promoters in neural and other cultured cells.
In Vitro Cell. Dev. Biol. Anim. 30:300-305(1994)

PubMed=7838528
Ngan Ching Cheng, Nadine Van Roy, Alvin Chan, Mabel Beitsma, Andries Westerveld, Frank Speleman, Rogier Versteeg;
Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.
Oncogene 10:291-297(1995)

PubMed=8617485; DOI=10.1016/S0046-8177(96)90115-X
Katia Scotlandi, Massimo Serra, Maria Cristina Manara, Stefania Benini, Manuela Sarti, Daniela Maurici, Pier-Luigi Lollini, Piero Picci, Francesco Bertoni, Nicola Baldini;
Immunostaining of the p30/32MIC2 antigen and molecular detection of EWS rearrangements for the diagnosis of Ewing's sarcoma and peripheral neuroectodermal tumor.
Hum. Pathol. 27:408-416(1996)

PubMed=8665486; DOI=10.1016/0304-3835(96)04250-4
Mitchell B. Diccianni, Lan S. Chau, Ayse Batova, Thai Q. Vu, Alice Lin-Tsing Yu;
The p16 and p18 tumor suppressor genes in neuroblastoma: implications for drug resistance.
Cancer Lett. 104:183-192(1996)

DOI=10.1007/0-306-46872-7_2
Carol Jeanne Thiele;
Neuroblastoma.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

PubMed=10074188; DOI=10.1128/JVI.73.4.3338-3350.1999; PMCID=PMC104098
Nathalie Arbour, Genevieve Cote, Claude Lachance, Marc Tardieu, Neil R. Cashman, Pierre J. Talbot;
Acute and persistent infection of human neural cell lines by human coronavirus OC43.
J. Virol. 73:3338-3350(1999)

PubMed=10630978; DOI=10.1667/0033-7587(2000)153[0062:FORIMI]2.0.CO;2
John M. Akudugu, Jacobus Petrus Slabbert, Antonio Mendes Serafin, Lothar Bohm;
Frequency of radiation-induced micronuclei in neuronal cells does not correlate with clonogenic survival.
Radiat. Res. 153:62-67(2000)

PubMed=11550280; DOI=10.1002/gcc.1174
Nadine Van Roy, Heidi Van Limbergen, Jo Vandesompele, Mireille Van Gele, Bruce Poppe, Helen R. Salwen, Genevieve Laureys, Nunes Manoel, Anne De Paepe, Frank Speleman;
Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.
Genes Chromosomes Cancer 32:126-135(2001)

PubMed=12702577
Fumiko Saito-Ohara, Issei Imoto, Jun Inoue, Hajime Hosoi, Akira Nakagawara, Tohru Sugimoto, Johji Inazawa;
PPM1D is a potential target for 17q gain in neuroblastoma.
Cancer Res. 63:1876-1883(2003)

PubMed=15390183; DOI=10.1002/gcc.20096
Sigrun Gebauer, Alice Lin-Tsing Yu, Motoko Omura-Minamisawa, Ayse Batova, Mitchell B. Diccianni;
Expression profiles and clinical relationships of ID2, CDKN1B, and CDKN2A in primary neuroblastoma.
Genes Chromosomes Cancer 41:297-308(2004)

PubMed=15892104; DOI=10.1002/gcc.20198
Yael P. Mosse, Joel Greshock, Adam A. Margolin, Tara Naylor, Kristina A. Cole, Deepa Khazi, George Hii, Cynthia Winter, Syed Shahzad, Muhammad Usman Asziz, Jaclyn A. Biegel ...Show all 13 authors... , Barbara L. Weber, John Matthew Maris; Show fewer authors
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846
Vincent Dam, Brian T. Morgan, Pavel Mazanek, Michael D. Hogarty;
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177.1-177.10(2006)

PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043
Yael P. Mosse, Marci Laudenslager, Luca Longo, Kristina A. Cole, Andrew Wood, Edward Fathi Attiyeh, Michael J. Laquaglia, Rachel Sennett, Jill E. Lynch, Patrizia Perri, Genevieve Laureys ...Show all 22 authors... , Frank Speleman, Cecilia Kim, Cui-Ping Hou, Hakon Hakonarson, Ali Torkamani, Nicholas J. Schork, Garrett M. Brodeur, Gian Paolo Tonini, Eric Rappaport, Marcella Devoto, John Matthew Maris; Show fewer authors
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=18923523; DOI=10.1038/nature07398
Isabelle Janoueix-Lerosey, Delphine Lequin, Laurence Brugieres, Agnes Ribeiro, Loic de Pontual, Valerie Combaret, Virginie Raynal, Alain Puisieux, Gudrun Schleiermacher, Gaelle Pierron, Dominique Valteau-Couanet ...Show all 16 authors... , Thierry Frebourg, Jean Michon, Stanislas Lyonnet, Jeanne Amiel, Olivier Delattre; Show fewer authors
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma.
Nature 455:967-970(2008)

PubMed=18923524; DOI=10.1038/nature07399
Yu-Yan Chen, Junko Takita, Young Lim Choi, Motohiro Kato, Miki Ohira, Masashi Sanada, Li-Li Wang, Manabu Soda, Akira Kikuchi, Takashi Igarashi, Akira Nakagawara ...Show all 14 authors... , Yasuhide Hayashi, Hiroyuki Mano, Seishi Ogawa; Show fewer authors
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)

PubMed=18957096; DOI=10.1186/1756-0500-1-95; PMCID=PMC2615028
Yuichiro Nishida, Naoki Adati, Ritsuko Ozawa, Aasami Maeda, Yoshiyuki Sakaki, Tadayuki Takeda;
Identification and classification of genes regulated by phosphatidylinositol 3-kinase- and TRKB-mediated signalling pathways during neuronal differentiation in two subtypes of the human neuroblastoma cell line SH-SY5Y.
BMC Res. Notes 1:95.1-95.11(2008)

PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132
Joanna E. Gawecka, Dirk Geerts, Jan Koster, Maisel J. Caliva, Florian J. Sulzmaier, John Opoku-Ansah, Randal K. Wada, Andre S. Bachmann, Joe W. Ramos;
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23325432; DOI=10.1101/gr.147942.112; PMCID=PMC3589544
Katherine E. Varley, Jason Gertz, Kevin M. Bowling, Stephanie L. Parker, Timothy E. Reddy, Florencia Pauli-Behn, Marie K. Cross, Brian A. Williams, John A. Stamatoyannopoulos, Gregory E. Crawford, Devin Michael Absher ...Show all 13 authors... , Barbara Jane Wold, Richard M. Myers; Show fewer authors
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703
Nadine Loschmann, Martin Michaelis, Florian Rothweiler, Richard Zehner, Jaroslaw Cinatl, Yvonne Voges, Mohsen Sharifi, Kristoffer Riecken, Jochen Meyer, Andreas von Deimling, Iduna Fichtner ...Show all 14 authors... , Taravat Ghafourian, Frank Westermann, Jindrich Cinatl Jr.; Show fewer authors
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315
Jo Lynne Harenza, Maura A. Diamond, Rebecca N. Adams, Michael M. Song, Heather L. Davidson, Lori S. Hart, Maiah H. Dent, Paolo Fortina, Charles Patrick Reynolds, John Matthew Maris;
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033.1-170033.8(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) AddexBio; C0005006/4924
ATCC; HTB-11
CancerTools; 161937
CCTCC; GDC0047
CLS; 305028
ECACC; 86012802
ICLC; HTL96019
IZSLER; BS TCL 143
KCB; KCB 200426YJ
KCLB; 30011
RCB; RCB0426
Ubigene; YC-C027
Cell line databases/resources CLO; CLO_0009059
CLO; CLO_0050268
MCCL; MCC:0000430
CLDB; cl4345
CLDB; cl4347
CLDB; cl4348
CLDB; cl4349
CLDB; cl4351
CLDB; cl4352
cancercelllines; CVCL_0531
CCRID; 1101HUM-PUMC000086
CCRID; 3101HUMSCSP5029
CCRID; 3101HUMTCHu51
CCRID; 4201HUM-CCTCC00047
Cell_Model_Passport; SIDM01098
CGH-DB; 62-1
CGH-DB; 9093-4
Cosmic-CLP; 717431
DepMap; ACH-000149
LINCS_LDP; LCL-1971
Lonza; 80
TOKU-E; 3149
Anatomy/cell type resources BTO; BTO_0001620
Biological sample resources BioSample; SAMN01821600
BioSample; SAMN03472879
BioSample; SAMN10987849
ENCODE; ENCBS007RAH
ENCODE; ENCBS018DDZ
ENCODE; ENCBS061YYT
ENCODE; ENCBS324TZB
ENCODE; ENCBS360ENC
ENCODE; ENCBS361ENC
ENCODE; ENCBS362ENC
ENCODE; ENCBS363ENC
ENCODE; ENCBS364ENC
ENCODE; ENCBS365ENC
ENCODE; ENCBS376ENC
ENCODE; ENCBS387WHS
ENCODE; ENCBS428ENC
ENCODE; ENCBS433ENC
ENCODE; ENCBS434ENC
ENCODE; ENCBS435ENC
ENCODE; ENCBS436ENC
ENCODE; ENCBS437ENC
ENCODE; ENCBS438ENC
ENCODE; ENCBS439KOM
ENCODE; ENCBS489AAA
ENCODE; ENCBS490AAA
ENCODE; ENCBS491AAA
ENCODE; ENCBS492AAA
ENCODE; ENCBS495AAA
ENCODE; ENCBS500EWH
ENCODE; ENCBS526AQV
ENCODE; ENCBS592MTQ
CRISP screens repositories BioGRID_ORCS_Cell_line; 1014
Chemistry resources ChEMBL-Cells; CHEMBL3307745
ChEMBL-Targets; CHEMBL614924
GDSC; 717431
PharmacoDB; SKNSH_1409_2019
PubChem_Cell_line; CVCL_0531
Encyclopedic resources Wikidata; Q28308636
Experimental variables resources EFO; EFO_0003072
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM231674
GEO; GSM231675
GEO; GSM231676
GEO; GSM231677
GEO; GSM231678
GEO; GSM231679
GEO; GSM231680
GEO; GSM231681
GEO; GSM231682
GEO; GSM231683
GEO; GSM231684
GEO; GSM231685
GEO; GSM231686
GEO; GSM231687
GEO; GSM231688
GEO; GSM231689
GEO; GSM231690
GEO; GSM231691
GEO; GSM231692
GEO; GSM231693
GEO; GSM314027
GEO; GSM333814
GEO; GSM563357
GEO; GSM692864
GEO; GSM803335
GEO; GSM887597
GEO; GSM888680
GEO; GSM923419
GEO; GSM923441
GEO; GSM1003626
GEO; GSM1003627
GEO; GSM1003628
GEO; GSM1003629
GEO; GSM1003630
GEO; GSM1003631
GEO; GSM1003632
GEO; GSM1003633
GEO; GSM1008585
GEO; GSM1010735
GEO; GSM1010738
GEO; GSM1010739
GEO; GSM1010750
GEO; GSM1010751
GEO; GSM1010763
GEO; GSM1010767
GEO; GSM1010773
GEO; GSM1010799
GEO; GSM1010806
GEO; GSM1010816
GEO; GSM1010817
GEO; GSM1010834
GEO; GSM1010835
GEO; GSM1010840
GEO; GSM1010858
GEO; GSM1010880
GEO; GSM1010887
GEO; GSM1010897
GEO; GSM1010900
GEO; GSM1010901
GEO; GSM1622296
GEO; GSM1670454
GEO; GSM2371259
GEO; GSM2394365
GEO; GSM2824362
GEO; GSM2824363
GEO; GSM4104597
GEO; GSM4104598
GEO; GSM4104637
GEO; GSM4104638
Polymorphism and mutation databases Cosmic; 697284
Cosmic; 717431
Cosmic; 801743
Cosmic; 848936
Cosmic; 922656
Cosmic; 923830
Cosmic; 930078
Cosmic; 947706
Cosmic; 1019929
Cosmic; 1037355
Cosmic; 1078393
Cosmic; 1082519
Cosmic; 1099151
Cosmic; 1109108
Cosmic; 1109371
Cosmic; 1153800
Cosmic; 1153806
Cosmic; 1162006
Cosmic; 1167420
Cosmic; 1167993
Cosmic; 1518079
Cosmic; 1526640
Cosmic; 2058116
Cosmic; 2131595
Cosmic; 2239469
Cosmic; 2393645
Cosmic; 2485952
IARC_TP53; 23584
Progenetix; CVCL_0531
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number50