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Cellosaurus SHEP-TR-miR-17-92 (CVCL_EI12)

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Cell line name SHEP-TR-miR-17-92
Accession CVCL_EI12
Resource Identification Initiative To cite this cell line use: SHEP-TR-miR-17-92 (RRID:CVCL_EI12)
Comments Population: Caucasian.
Characteristics: Transfected with a Tet-on system to induce the oncogenic miR-17-92 cluster with the addition of tetracycline to the culture medium.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 (HHV-1) VP16 (UL28) (Note=With p.Met1_Arg360del).
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0524 (SH-EP)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
Publications

PubMed=21145484; DOI=10.1016/j.molcel.2010.11.038; PMCID=PMC3032380
Pieter Mestdagh, Anna-Karin Bostrom, Francis Impens, Erik Fredlund, Gert Van Peer, Pasqualino De Antonellis, Kristoffer von Stedingk, Bart Ghesquiere, Stefanie Schulte, Michael Dews, Andrei Thomas-Tikhonenko ...Show all 18 authors... , Johannes Hubertus Schulte, Massimo Zollo, Alexander Schramm, Kris Gevaert, Hakan Axelson, Frank Speleman, Jo Vandesompele; Show fewer authors
The miR-17-92 microRNA cluster regulates multiple components of the TGF-beta pathway in neuroblastoma.
Mol. Cell 40:762-773(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_EI12
Encyclopedic resources Wikidata; Q54953289
Proteomic databases PRIDE; PRD000321
Entry history
Entry creation13-Jul-2016
Last entry update14-Aug-2025
Version number15