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Cellosaurus FRTL-5 (CVCL_0265)

[Text version]
Cell line name FRTL-5
Synonyms FRTL 5; FRTL5; FRTL-5 Cl 2
Accession CVCL_0265
Resource Identification Initiative To cite this cell line use: FRTL-5 (RRID:CVCL_0265)
Comments Group: Patented cell line.
Group: Space-flown cell line (cellonaut).
Problematic cell line: Probably misclassified/misidentified. ECACC has discontinued this cell line because it does not display the non-diploid karyotype originally reported therefore its authenticity cannot be assured.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8305.
Doubling time: 34 hours (CelloPub=CLPUB00429); 30 hours (PubMed=3670314).
Anecdotal: Have been flown in space on the ISS in 2005 to study the effect of UVC radiation (PubMed=21087161).
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Fischer.
Hierarchy Parent: CVCL_5753 (FRTL)
Sex of cell Sex unspecified
Age at sampling 6W
Category Spontaneously immortalized cell line

PubMed=6327870; DOI=10.1677/joe.0.1010269
Bidey S.P., Chiovato L., Day A., Turmaine M., Gould R.P., Ekins R.P., Marshall N.J.
Evaluation of the rat thyroid cell strain FRTL-5 as an in-vitro bioassay system for thyrotrophin.
J. Endocrinol. 101:269-276(1984)

Ambesi-Impiombato F.S.
Living, fast-growing thyroid cell strain, FRTL-5.
Patent number US4608341, 26-Aug-1986

PubMed=2868604; DOI=10.1530/acta.0.1110054
Brandi M.L., Rotella C.M., Zonefrati R., Toccafondi R., Aloj S.M.
Loss of adrenergic regulation of cAMP production in the FRTL-5 cell line.
Acta Endocrinol. 111:54-61(1986)

PubMed=3475907; DOI=10.1530/acta.0.114s242
Ambesi-Impiombato F.S., Villone G.
The FRTL-5 thyroid cell strain as a model for studies on thyroid cell growth.
Acta Endocrinol. 116 Suppl. 281:242-245(1987)

PubMed=3670314; DOI=10.1128/mcb.7.9.3365-3370.1987
Fusco A., Berlingieri M.T., Di Fiore P.P., Portella G., Grieco M., Vecchio G.
One- and two-step transformations of rat thyroid epithelial cells by retroviral oncogenes.
Mol. Cell. Biol. 7:3365-3370(1987)

PubMed=2545492; DOI=10.1016/0303-7207(89)90020-8
Sugawa H., Mori T., Imura H.
Establishment of 8-azaguanine-resistant mutants from rat thyroid cell line FRTL-5.
Mol. Cell. Endocrinol. 62:319-326(1989)

PubMed=2551628; DOI=10.1210/endo-125-4-1783
Pang X.-P., Hershman J.M., Chung M., Pekary A.E.
Characterization of tumor necrosis factor-alpha receptors in human and rat thyroid cells and regulation of the receptors by thyrotropin.
Endocrinology 125:1783-1788(1989)

PubMed=1694496; DOI=10.1210/endo-127-1-419
Ossendorp F.A., Bruning P.F., Schuuring E.M.D., van den Brink J.A.M., van der Heide D., de Vijlder J.J.M., de Bruin T.W.A.
Thyrotropin dependent and independent thyroid cell lines selected from FRTL-5 derived tumors grown in nude mice.
Endocrinology 127:419-430(1990)

Gerber H., Peter H.-J., Bosiger J., Studer H., Drews R., Ferguson D.C., Peterson M.E., Becker D.V.
Different continuous cell lines from adenomatous feline goiters widely differ in morphologic, functional and growth parameters.
(In) Progress in thyroid research. Proceedings of the 10th International Thyroid Conference; Gordon A., Gross J., Hennemann G. (eds.); pp.541-544; A A Balkema Publishers; Rotterdam (1991)

Peter H.-J., Gerber H., Studer H., Groscurth P., Zakarija M.
Thyroid cell lines forming follicle-like lumina in vitro.
(In) Progress in thyroid research. Proceedings of the 10th International Thyroid Conference; Gordon A., Gross J., Hennemann G. (eds.); pp.579-582; A A Balkema Publishers; Rotterdam (1991)

Gerber H., Peter H.-J., Asmis L., Studer H.
Thyroid cell lines in research on goitrogenesis.
Thyroidology 3:115-118(1991)

PubMed=1846098; DOI=10.1210/endo-128-1-211
Peter H.-J., Gerber H., Studer H., Groscurth P., Zakarija M.
Comparison of FRTL-5 cell growth in vitro with that of xenotransplanted cells and the thyroid of the recipient mouse.
Endocrinology 128:211-219(1991)

PubMed=7836899; DOI=10.1677/joe.0.1430527
MacNeil S., Munro D.S., Metcalfe R., Cotterell S., Ruban L.N., Davies R., Weetman A.P.
An investigation of the ability of TSH and Graves' immunoglobulin G to increase intracellular calcium in human thyroid cells, rat FRTL-5 thyroid cells and eukaryotic cells transfected with the human TSH receptor.
J. Endocrinol. 143:527-540(1994)

PubMed=7912172; DOI=10.1111/j.1365-2265.1994.tb03017.x
Michelangeli V.P., Munro D.S., Poon C.W., Frauman A.G., Colman P.G.
Measurement of thyroid stimulating immunoglobulins in a new cell line transfected with a functional human TSH receptor (JPO9 cells), compared with an assay using FRTL-5 cells.
Clin. Endocrinol. (Oxf.) 40:645-652(1994)

PubMed=8761378; DOI=10.1038/bjc.1996.409
van der Kallen C.J.H., Coes J.H., van Grafhorst J.P., Schuuring E.M.D., Ossendorp F.A., Thijssen J.H.H., Blankenstein M.A., de Bruin T.W.A.
Dissociation of thyrotropin receptor function and thyrotropin dependency in rat thyroid tumour cell lines derived from FRTL-5.
Br. J. Cancer 74:606-612(1996)

PubMed=9709917; DOI=10.1089/thy.1998.8.623
Tasevski V., Benn D., Peters G., Luttrell B., Simpson A.
The Fischer rat thyroid cell line FRTL-5 exhibits a nondiploid karyotype.
Thyroid 8:623-626(1998)

PubMed=20151827; DOI=10.1089/thy.2009.0171
Sebai H., Hovsepian S., Ristorcelli E., Aouani A., Lombardo D., Fayet G.
Resveratrol increases iodide trapping in the rat thyroid cell line FRTL-5.
Thyroid 20:195-203(2010)

PubMed=21087161; DOI=10.1089/ast.2010.0461
Albi E., Ambesi-Impiombato F.S., Villani M., De Pol I., Spelat R., Lazzarini R., Perrella G.
Thyroid cell growth: sphingomyelin metabolism as non-invasive marker for cell damage acquired during spaceflight.
Astrobiology 10:811-820(2010)

Fusco A., Berlingieri M.T., Di Fiore P.P., Portella G., Grieco M., Vecchio G.
Retraction for Fusco et al., 'One- and two-step transformations of rat thyroid epithelial cells by retroviral oncogenes'.
Mol. Cell. Biol. 38:e00663.17.1-e00663.17.1(2018)

Cell line collections (Providers) CLS; 500407
ECACC; 91030711 - Discontinued
Cell line databases/resources CLO; CLO_0003396
MCCL; MCC:0000156
CLDB; cl1395
Anatomy/cell type resources BTO; BTO:0001875
Chemistry resources ChEMBL-Cells; CHEMBL3308088
ChEMBL-Targets; CHEMBL613879
PubChem_Cell_line; CVCL_0265
Encyclopedic resources Wikidata; Q54835180
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number26