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Cellosaurus BT-474 (CVCL_0179)

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Cell line name BT-474
Synonyms Bt-474; BT474
Accession CVCL_0179
Resource Identification Initiative To cite this cell line use: BT-474 (RRID:CVCL_0179)
Comments Part of: AKT genetic alteration cell panel (ATCC TCP-1029).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: EGFR genetic alteration cell panel (ATCC TCP-1027).
Part of: ERK genetic alteration cell panel (ATCC TCP-1033).
Part of: ICBP43 breast cancer cell line panel.
Part of: JWGray breast cancer cell line panel.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Doubling time: 3.5 days (PubMed=9671407); 78 hours (PubMed=25984343); 45.8 hours (PubMed=24389870); ~60-80 hours (CLS=300131); ~100 hours (DSMZ=ACC-64); 92.49 hours (JWGray panel).
Microsatellite instability: Stable (MSS) (PubMed=23671654; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Metabolomics.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; PTM; Glycoproteome.
Omics: Proteomics; PTM; Phosphorylation.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Anecdotal: Used in a study utilising the fruit fly's olfactory system to detect cancer cells (PubMed=24389870).
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
HLA typing Source: PubMed=25960936
Class I
HLA-AA*29:02
HLA-BB*07:02
HLA-CC*07:02,16:01
Class II
HLA-DQDQB1*03:04,06:02
HLA-DRDRB1*15:01,15:01

Source: PubMed=26589293
Class I
HLA-AA*02:46,29:02
HLA-BB*07:02,35:08
HLA-CC*07:02,16:01
Class II
HLA-DQDQB1*03:02,06:02
HLA-DRDRB1*04:05,15:01

Source: CLS=300131
Class I
HLA-AA*01:01:01,05:02:01
HLA-BB*07:02:01,20:03:01
HLA-CC*07:02:01,16:01:01
Class II
HLA-DPDPB1*04:01:01G,05:01:01G
HLA-DQDQA1*01:02:01,03:03:01
DQB1*06:02:01
HLA-DRDRB1*04:01,15:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.6
Native American0
East Asian, North2.47
East Asian, South0
South Asian0
European, North70.19
European, South26.74
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_AQ07 (BT-474 Clone 5)CVCL_A4CL (BT-474 Ecadherin EmGFP)CVCL_AR96 (BT-474 EEI)
CVCL_AR86 (BT-474 Tam1)CVCL_A4AK (BT-474 Tam2)CVCL_C9CU (BT-474-Luc2)
CVCL_4Y08 (BT-474/CMV-Luc)CVCL_IP20 (BT-474c1)CVCL_YX79 (BT474 A3)
CVCL_4V65 (BT474-5FU[r])CVCL_ZL46 (BT474-J4)CVCL_EI02 (BT474-LAPRa)
CVCL_EI03 (BT474-LAPRb)CVCL_VL01 (BT474-LR)CVCL_A2GH (LR-BT474)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0006012/4902; ATCC=HTB-20; CCRID; CLS=300131; Cosmic-CLP=946359; DSMZ=ACC-64; KCLB=60062; PubMed=25877200; PubMed=28889351; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO10,11
D1S165613,15.3
D2S44110,14
D2S133819
D3S135817
D5S81811,13
D7S8209,12
D8S117910,12
D10S124815
D12S39117,18
D13S31711
D16S5399,11
D18S5113,18
D19S43314,17
D21S1128,32.2
D22S104514
FGA22,25
Penta D9,14
Penta E5
TH017
TPOX8
vWA15,16

Run an STR similarity search on this cell line
Web pages Info; LINCS; ICBP43; https://lincs.hms.harvard.edu/resources/reagents/icbp43/
Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/breast-cancer-xenograft/bt474-xenograft-model/
Publications

PubMed=212572; DOI=10.1093/jnci/61.4.967
Etienne Yves Lasfargues, William G. Coutinho, Ernest S. Redfield;
Isolation of two human tumor epithelial cell lines from solid breast carcinomas.
J. Natl. Cancer Inst. 61:967-978(1978)

PubMed=94035; DOI=10.1007/BF02618252
Etienne Yves Lasfargues, William G. Coutinho, Arnold S. Dion;
A human breast tumor cell line (BT-474) that supports mouse mammary tumor virus replication.
In Vitro 15:723-729(1979)

DOI=10.1007/978-1-4757-0019-0_7
Etienne Yves Lasfargues, William G. Coutinho;
Human breast tumor cells in culture; new concepts in mammary carcinogenesis.
(In book chapter) New frontiers in mammary pathology; Hollmann, Karl H. & de Brux, Jean & Verley, Jeanne M. (eds.); pp.117-143; Plenum Press; New York; USA (1981)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=1961733; DOI=10.1073/pnas.88.23.10657; PMCID=PMC52989
Ingo Bernard Runnebaum, Mahalakshmi Nagarajan, Marianne Bowman, Darya Soto, Saraswati Sukumar;
Mutations in p53 as potential molecular markers for human breast cancer.
Proc. Natl. Acad. Sci. U.S.A. 88:10657-10661(1991)

DOI=10.1016/B978-0-12-333530-2.50009-5
Albert Leibovitz;
Cell lines from human breast.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.161-184; Academic Press; New York; USA (1994)

PubMed=7842014; DOI=10.1038/ng1094-155
Xin-Yuan Guan, Paul S. Meltzer, William S. Dalton, Jeffrey M. Trent;
Identification of cryptic sites of DNA sequence amplification in human breast cancer by chromosome microdissection.
Nat. Genet. 8:155-161(1994)

PubMed=9671407; DOI=10.1038/sj.onc.1201814
Kimberley J. Sweeney, Alexander Swarbrick, Robert Lyndsay Sutherland, Elizabeth A. Musgrove;
Lack of relationship between CDK activity and G1 cyclin expression in breast cancer cells.
Oncogene 16:2865-2878(1998)

PubMed=10862037; DOI=10.1002/1098-2264(200007)28:3<308::AID-GCC9>3.0.CO;2-B
Soili Kytola, Jaana Rummukainen, Ann Nordgren, Ritva Karhu, Filip Farnebo, Jorma J. Isola, Catharina Larsson;
Chromosomal alterations in 15 breast cancer cell lines by comparative genomic hybridization and spectral karyotyping.
Genes Chromosomes Cancer 28:308-317(2000)

PubMed=10969801
Farahnaz Forozan, Eija H. Mahlamaki, Outi Monni, Yi-Dong Chen, Robin Veldman, Yuan Jiang, Gerald C. Gooden, Stephen P. Ethier, Anne H. Kallioniemi, Olli-Pekka Kallioniemi;
Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data.
Cancer Res. 60:4519-4525(2000)

PubMed=11343771; DOI=10.1016/S0165-4608(00)00387-3
Jaana Rummukainen, Soili Kytola, Ritva Karhu, Filip Farnebo, Catharina Larsson, Jorma J. Isola;
Aberrations of chromosome 8 in 16 breast cancer cell lines by comparative genomic hybridization, fluorescence in situ hybridization, and spectral karyotyping.
Cancer Genet. Cytogenet. 126:1-7(2001)

PubMed=11687795; DOI=10.1038/ng754
Antoine M. Snijders, Norma Jean Nowak, Richard Segraves, Stephanie Blackwood, Nils Brown, Jeffrey Conroy, Greg Hamilton, Anna Katherine Hindle, Bing Huey, Karen Kimura, Sindy Law ...Show all 19 authors... , Ken Myambo, Joel Palmer, Bauke Ylstra, Jingzhu Pearl Yue, Joe W. Gray, Ajay N. Jain, Daniel Pinkel, Donna G. Albertson; Show fewer authors
Assembly of microarrays for genome-wide measurement of DNA copy number.
Nat. Genet. 29:263-264(2001)

PubMed=12353263; DOI=10.1002/gcc.10107
Cornel Popovici, Celine Basset, Francois Bertucci, Beatrice Orsetti, Jose Adelaide, Marie-Joelle Mozziconacci, Nathalie Conte, Anne Murati, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Stephen P. Ethier ...Show all 15 authors... , Marina Lafage-Pochitaloff, Charles Theillet, Daniel Birnbaum, Max Chaffanet; Show fewer authors
Reciprocal translocations in breast tumor cell lines: cloning of a t(3;20) that targets the FHIT gene.
Genes Chromosomes Cancer 35:204-218(2002)

PubMed=12800145; DOI=10.1002/gcc.10218
Jose Adelaide, Huai-En Huang, Anne Murati, Amber E. Alsop, Beatrice Orsetti, Marie-Joelle Mozziconacci, Cornel Popovici, Christophe Ginestier, Anne Letessier, Celine Basset, Celine Courtay-Cahen ...Show all 16 authors... , Jocelyne Jacquemier, Charles Theillet, Daniel Birnbaum, Paul A.W. Edwards, Max Chaffanet; Show fewer authors
A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene.
Genes Chromosomes Cancer 37:333-345(2003)

PubMed=16142302; DOI=10.3892/ijo.27.4.881
Francoise de Longueville, Marc Lacroix, Anna-Maria Barbuto, Vincent Bertholet, Dominique Gallo, Denis Larsimont, Laurence Marcq, Nathalie Zammatteo, Sophie Boffe, Guy Leclercq, Jose Remacle;
Molecular characterization of breast cancer cell lines by a low-density microarray.
Int. J. Oncol. 27:881-892(2005)

PubMed=16195238; DOI=10.1093/carcin/bgi231
Erum A. Hussain-Hakimjee, Xin-Jian Peng, Rajeshwari R. Mehta, Rajendra G. Mehta;
Growth inhibition of carcinogen-transformed MCF-12F breast epithelial cells and hormone-sensitive BT-474 breast cancer cells by 1alpha-hydroxyvitamin D5.
Carcinogenesis 27:551-559(2006)

PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853
Fons Elstrodt, Antoinette Hollestelle, Jord H.A. Nagel, Michael Gorin, Marijke Wasielewski, Ans M.W. van den Ouweland, Sofia Diana Merajver, Stephen P. Ethier, Mieke Schutte;
BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.
Cancer Res. 66:41-45(2006)

PubMed=16417655; DOI=10.1186/bcr1370; PMCID=PMC1413994
Ashleen Shadeo, Wan L. Lam;
Comprehensive copy number profiles of breast cancer cell model genomes.
Breast Cancer Res. 8:R9.1-R9.14(2006)

PubMed=16541312; DOI=10.1007/s10549-006-9186-z
Marijke Wasielewski, Fons Elstrodt, Jan G.M. Klijn, Els M.J.J. Berns, Mieke Schutte;
Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines.
Breast Cancer Res. Treat. 99:97-101(2006)

PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521
Richard M. Neve, Koei Chin, Jane Fridlyand, Jennifer Yeh, Frederick L. Baehner, Tea Fevr, Laura Clark, Nora Bayani, Jean-Philippe Coppe, Frances Tong, Terry Speed ...Show all 27 authors... , Paul T. Spellman, Sandy DeVries, Anna Lapuk, Nick J. Wang, Wen-Lin Kuo, Jackie L. Stilwell, Daniel Pinkel, Donna G. Albertson, Frederic M. Waldman, Frank McCormick, Robert Brent Dickson, Michael D. Johnson, Marc E. Lippman, Stephen P. Ethier, Adi F. Gazdar, Joe W. Gray; Show fewer authors
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Cancer Cell 10:515-527(2006)

PubMed=17334996; DOI=10.1002/gcc.20438
Goran Jonsson, Johan Staaf, Eleonor Olsson, Markus Heidenblad, Johan Vallon-Christersson, Kazutoyo Osoegawa, Pieter J. de Jong, Stina M. Oredsson, Markus Ringner, Mattias Hoglund, Ake Borg;
High-resolution genomic profiles of breast cancer cell lines assessed by tiling BAC array comparative genomic hybridization.
Genes Chromosomes Cancer 46:543-558(2007)

PubMed=18516279; DOI=10.1016/j.molonc.2007.02.004; PMCID=PMC2391005
Paraic A. Kenny, Genee Y. Lee, Connie A. Myers, Richard M. Neve, Jeremy R. Semeiks, Paul T. Spellman, Kristina Lorenz, Eva H. Lee, Mary Helen Barcellos-Hoff, Ole William Petersen, Joe W. Gray, Mina J. Bissell;
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.
Mol. Oncol. 1:84-96(2007)

PubMed=18386134; DOI=10.1007/s10585-008-9169-z
Linda Hughes, Catherine Malone, Saranya Chumsri, Angelika Maria Burger, Susan McDonnell;
Characterisation of breast cancer cell lines and establishment of a novel isogenic subclone to study migration, invasion and tumourigenicity.
Clin. Exp. Metastasis 25:549-557(2008)

PubMed=19582160; DOI=10.1371/journal.pone.0006146; PMCID=PMC2702084
Jessica Kao, Keyan Salari, Melanie Bocanegra, Yoon-La Choi, Luc Girard, Jeet Gandhi, Kevin A. Kwei, Tina Hernandez-Boussard, Pei Wang, Adi F. Gazdar, John D. Minna, Jonathan R. Pollack;
Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.
PLoS ONE 4:e6146.1-e6146.16(2009)

PubMed=19671800; DOI=10.1158/0008-5472.CAN-08-4490
Li Liu, James G. Greger, Hong Shi, Yuan Liu, Joel Greshock, Roland Annan, Wendy Halsey, Ganesh M. Sathe, Anne-Marie Martin, Tona Morgan Gilmer;
Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL.
Cancer Res. 69:6871-6878(2009)

PubMed=19727395; DOI=10.1371/journal.pone.0006888; PMCID=PMC2731225
Raymond Couric Wadlow, Ben S. Wittner, S. Aidan Finley, Henry Bergquist, Rabi Upadhyay, Stephen P. Finn, Massimo Loda, Umar Mahmood, Sridhar Ramaswamy;
Systems-level modeling of cancer-fibroblast interaction.
PLoS ONE 4:e6888.1-e6888.10(2009)

DOI=10.25904/1912/1434
Brian J. Morrison;
Breast cancer stem cells: tumourspheres and implications for therapy.
Thesis PhD (2010); Griffith University; Brisbane; Australia

PubMed=19593635; DOI=10.1007/s10549-009-0460-8
Antoinette Hollestelle, Jord H.A. Nagel, Marcel Smid, Suzanne Lam, Fons Elstrodt, Marijke Wasielewski, Ser Sue Ng, Pim J. French, Justine K. Peeters, Marieke J. Rozendaal, Muhammad Riaz ...Show all 26 authors... , Daphne G. Koopman, Timo L.M. ten Hagen, Bertie H.C.G.M. de Leeuw, Ellen C. Zwarthoff, Amina F.A.S. Teunisse, Peter J. van der Spek, Jan G.M. Klijn, Winand N.M. Dinjens, Stephen P. Ethier, Hans Cornelius Clevers, Aart G. Jochemsen, Michael A. den Bakker, John A. Foekens, John W.M. Martens, Mieke Schutte; Show fewer authors
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.
Breast Cancer Res. Treat. 121:53-64(2010)

PubMed=20070913; DOI=10.1186/1471-2407-10-15; PMCID=PMC2836299
Katumi Tsuji, Shigeto Kawauchi, Soichiro Saito, Tomoko Furuya, Kenzo Ikemoto, Motonao Nakao, Shigeru Yamamoto, Masaaki Oka, Takashi Hirano, Kohsuke Sasaki;
Breast cancer cell lines carry cell line-specific genomic alterations that are distinct from aberrations in breast cancer tissues: comparison of the CGH profiles between cancer cell lines and primary cancer tissues.
BMC Cancer 10:15.1-15.10(2010)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21247443; DOI=10.1186/gb-2011-12-1-r6; PMCID=PMC3091304
Henrik Edgren, Astrid Murumagi, Sara Kangaspeska, Daniel Nicorici, Vesa Hongisto, Kristine Kleivi, Inga H. Rye, Sandra Nyberg, Maija Wolf, Anne-Lise Borresen-Dale, Olli-Pekka Kallioniemi;
Identification of fusion genes in breast cancer by paired-end RNA-sequencing.
Genome Biol. 12:R6.1-R6.13(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396
Richard Marcotte, Kevin R. Brown, Fernando Jose Suarez Saiz, Azin Sayad, Konstantina Karamboulas, Paul M. Krzyzanowski, Fabrice Sircoulomb, Mauricio Medrano, Yaroslav Fedyshyn, Judice Lie-Yong Koh, Dewald van Dyk ...Show all 28 authors... , Bohdana Fedyshyn, Marianna Luhova, Glauber C. Brito, Franco J. Vizeacoumar, Frederick S. Vizeacoumar, Alessandro Datti, Dahlia Kasimer, Alla Buzina, Patricia Mero, Christine Misquitta, Josee Normand, Maliha Haider, Troy Ketela, Jeffrey L. Wrana, Robert Rottapel, Benjamin G. Neel, Jason Moffat; Show fewer authors
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
Cancer Discov. 2:172-189(2012)

PubMed=23151021; DOI=10.1186/1471-2164-13-619; PMCID=PMC3546428
Anita Grigoriadis, Alan Mackay, Elodie Noel, Pei-Jun Wu, Rachael Natrajan, Jessica Frankum, Jorge Sergio Reis-Filho, Andrew Tutt;
Molecular characterisation of cell line models for triple-negative breast cancers.
BMC Genomics 13:619.1-619.14(2012)

PubMed=23601657; DOI=10.1186/bcr3415; PMCID=PMC3672661
Muhammad Riaz, Marijn T.M. van Jaarsveld, Antoinette Hollestelle, Wendy J.C. Prager-van der Smissen, Anouk A.J. Heine, Antonius W.M. Boersma, Jing-Jing Liu, Jean C.A. Helmijr, Bahar Ozturk, Marcel Smid, Erik A.C. Wiemer ...Show all 13 authors... , John A. Foekens, John W.M. Martens; Show fewer authors
miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.
Breast Cancer Res. 15:R33.1-R33.17(2013)

PubMed=23671654; DOI=10.1371/journal.pone.0063056; PMCID=PMC3646030
Yu-Heng Lu, T. David Soong, Olivier Elemento;
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:e63056.1-e63056.10(2013)

PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020; PMCID=PMC3931310
Luika A. Timmerman, Thomas Holton, Mariia Yuneva, Raymond J. Louie, Merce Padro, Anneleen Daemen, Min Hu, Denise A. Chan, Stephen P. Ethier, Laura J. van 't Veer, Kornelia Polyak ...Show all 13 authors... , Frank McCormick, Joe W. Gray; Show fewer authors
Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.
Cancer Cell 24:450-465(2013)

PubMed=24162158; DOI=10.1007/s10549-013-2743-3; PMCID=PMC3832776
Aleix Prat, Olga Karginova, Joel S. Parker, Cheng Fan, Xia-Ping He, Lisa M. Bixby, J. Chuck Harrell, Erick Roman, Barbara Adamo, Melissa A. Troester, Charles M. Perou;
Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.
Breast Cancer Res. Treat. 142:237-255(2013)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590
Anneleen Daemen, Obi L. Griffith, Laura M. Heiser, Nicholas J. Wang, Oana M. Enache, Zachary Sanborn, Francois Pepin, Steffen Durinck, James E. Korkola, Malachi Griffith, Joe S. Hur ...Show all 27 authors... , Nam Huh, Jongsuk Chung, Leslie Cope, Mary Jo Fackler, Christopher Benedict Umbricht, Saraswati Sukumar, Pankaj Seth, Vikas P. Sukhatme, Lakshmi R. Jakkula, Yi-Ling Lu, Gordon B. Mills, Raymond J. Cho, Eric A. Collisson, Laura J. van 't Veer, Paul T. Spellman, Joe W. Gray; Show fewer authors
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=24389870; DOI=10.1038/srep03576; PMCID=PMC3880960
Martin Strauch, Alja Ludke, Daniel Munch, Thomas Laudes, Cosmas Giovanni Galizia, Eugenio Martinelli, Luca Lavra, Roberto Paolesse, Alessandra Ulivieri, Alexandro Catini, Rosamaria Capuano, Corrado Di Natale;
More than apples and oranges -- detecting cancer with a fruit fly's antenna.
Sci. Rep. 4:3576.1-3576.9(2014)

PubMed=24456987; DOI=10.1186/1755-8166-7-8; PMCID=PMC3914704
Milena Rondon-Lagos, Ludovica Verdun Di Cantogno, Caterina Marchio, Nelson Rangel, Cesar Payan-Gomez, Patrizia Gugliotta, Cristina Botta, Gianni Bussolati, Sandra R. Ramirez-Clavijo, Barbara Pasini, Anna Sapino;
Differences and homologies of chromosomal alterations within and between breast cancer cell lines: a clustering analysis.
Mol. Cytogenet. 7:8.1-8.14(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=25892236; DOI=10.1016/j.celrep.2015.03.050; PMCID=PMC4425736
Robert T. Lawrence, Elizabeth M. Perez, Daniel Hernandez, Chris P. Miller, Kelsey M. Haas, Hanna Y. Irie, Su-In Lee, C. Anthony Blau, Judit Villen;
The proteomic landscape of triple-negative breast cancer.
Cell Rep. 11:630-644(2015)

PubMed=26218769; DOI=10.1016/j.jchromb.2015.07.021
Lucas Willmann, Manuel Schlimpert, Sebastian Halbach, Thalia Erbes, Elmar Stickeler, Bernd Kammerer;
Metabolic profiling of breast cancer: differences in central metabolism between subtypes of breast cancer cell lines.
J. Chromatogr. B 1000:95-104(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=26865974; DOI=10.1186/s13742-016-0113-x; PMCID=PMC4748558
Serban Ciotlos, Qing Mao, Rebecca Yu Zhang, Zhen-Yu Li, Robert Chin, Natali Gulbahce, Sophie Jia Liu, Radoje Drmanac, Brock Andrew Peters;
Whole genome sequence analysis of BT-474 using Complete Genomics' standard and long fragment read technologies.
GigaScience 5:8.1-8.17(2016)

PubMed=27362937; DOI=10.1371/journal.pone.0157290; PMCID=PMC4928811
Marilyn Carrier, Mathilde Joint, Regis Lutzing, Adeline Page, Cecile Rochette-Egly;
Phosphoproteome and transcriptome of RA-responsive and RA-resistant breast cancer cell lines.
PLoS ONE 11:e0157290.1-e0157290.23(2016)

PubMed=27378269; DOI=10.1186/s12885-016-2452-5; PMCID=PMC4932681
Sara Kangaspeska, Susanne Hultsch, Alok Jaiswal, Henrik Edgren, John Patrick Mpindi, Samuli Eldfors, Oscar Bruck, Tero Aittokallio, Olli-Pekka Kallioniemi;
Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer.
BMC Cancer 16:378.1-378.17(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28287265; DOI=10.1021/acs.jproteome.6b00470; PMCID=PMC5557415
Ten-Yang Yen, Spencer Bowen, Roger Yen, Alexandra Piryatinska, Bruce A. Macher, Leslie C. Timpe;
Glycoproteins in claudin-low breast cancer cell lines have a unique expression profile.
J. Proteome Res. 16:1391-1400(2017)

PubMed=28889351; DOI=10.1007/s10549-017-4496-x
Jodi M. Saunus, Chanel E. Smart, Jamie R. Kutasovic, Rebecca L. Johnston, Priyakshi Kalita-de Croft, Mariska Miranda, Esdy N. Rozali, Ana Cristina Vargas, Lynne E. Reid, Eva Lorsy, Sibylle Cocciardi ...Show all 23 authors... , Tatjana Seidens, Amy Ellen McCart Reed, Andrew J. Dalley, Leesa F. Wockner, Julie Johnson, Debina Sarkar, Marjan E. Askarian-Amiri, Peter T. Simpson, Kum Kum Khanna, Georgia Chenevix-Trench, Fares Al-Ejeh, Sunil R. Lakhani; Show fewer authors
Multidimensional phenotyping of breast cancer cell lines to guide preclinical research.
Breast Cancer Res. Treat. 167:289-301(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=32942617; DOI=10.3390/cancers12092630; PMCID=PMC7564044
Hye Jin Lee, Seungho Shin, Jinho Kang, Ki-Cheol Han, Yeul Hong Kim, Jeoung-Won Bae, Kyong Hwa Park;
HSP90 inhibitor, 17-DMAG, alone and in combination with lapatinib attenuates acquired lapatinib-resistance in ER-positive, HER2-overexpressing breast cancer cell line.
Cancers (Basel) 12:2630.1-2630.16(2020)

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Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) AddexBio; C0006012/4902
ATCC; CRL-7913 - Discontinued
ATCC; HTB-20
BCRC; 60359
BCRJ; 0353
CLS; 300131
DSMZ; ACC-64
IBRC; C10140
ICLC; HTL00008
KCB; KCB 2011115YJ
KCLB; 60062
NCBI_Iran; C435
Cell line databases/resources CLO; CLO_0002042
MCCL; MCC:0000070
CLDB; cl497
CLDB; cl498
CLDB; cl4997
cancercelllines; CVCL_0179
CCRID; 1101HUM-PUMC000129
CCRID; 1102HUM-NIFDC00023
CCRID; 3101HUMTCHu143
CCRID; 4201HUM-CCTCC00636
Cell_Model_Passport; SIDM00963
Cosmic-CLP; 946359
DepMap; ACH-000927
DSMZCellDive; ACC-64
IGRhCellID; BT474
LINCS_HMS; 50106
LINCS_LDP; LCL-1308
TOKU-E; 694
Anatomy/cell type resources BTO; BTO_0001932
Biological sample resources BioSample; SAMN01821539
BioSample; SAMN01821618
BioSample; SAMN03473029
BioSample; SAMN10988308
BioSamples; SAMEA3516847
BioSamples; SAMEA3516848
BioSamples; SAMEA3516849
Chemistry resources ChEMBL-Cells; CHEMBL3307636
ChEMBL-Targets; CHEMBL614529
GDSC; 946359
PharmacoDB; BT474_109_2019
PubChem_Cell_line; CVCL_0179
Encyclopedic resources Wikidata; Q54798460
Experimental variables resources EFO; EFO_0001093
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-TABM-157
ArrayExpress; E-TABM-244
GEO; GSM1716
GEO; GSM1725
GEO; GSM69198
GEO; GSM73557
GEO; GSM73702
GEO; GSM115110
GEO; GSM147888
GEO; GSM147957
GEO; GSM149981
GEO; GSM149989
GEO; GSM149997
GEO; GSM155210
GEO; GSM184392
GEO; GSM184393
GEO; GSM213707
GEO; GSM213717
GEO; GSM213718
GEO; GSM213719
GEO; GSM213737
GEO; GSM213740
GEO; GSM213743
GEO; GSM213745
GEO; GSM217615
GEO; GSM274657
GEO; GSM276780
GEO; GSM320173
GEO; GSM344341
GEO; GSM344391
GEO; GSM350504
GEO; GSM388211
GEO; GSM421861
GEO; GSM533397
GEO; GSM533412
GEO; GSM590105
GEO; GSM679677
GEO; GSM679678
GEO; GSM679679
GEO; GSM679680
GEO; GSM679681
GEO; GSM679682
GEO; GSM679683
GEO; GSM679684
GEO; GSM679685
GEO; GSM679686
GEO; GSM679687
GEO; GSM679688
GEO; GSM679689
GEO; GSM679690
GEO; GSM679691
GEO; GSM783958
GEO; GSM799168
GEO; GSM799169
GEO; GSM799170
GEO; GSM799171
GEO; GSM799172
GEO; GSM799173
GEO; GSM843476
GEO; GSM847198
GEO; GSM847453
GEO; GSM886892
GEO; GSM887957
GEO; GSM903063
GEO; GSM903064
GEO; GSM903065
GEO; GSM903066
GEO; GSM903067
GEO; GSM903068
GEO; GSM903069
GEO; GSM967821
GEO; GSM1008891
GEO; GSM1053692
GEO; GSM1172853
GEO; GSM1172941
GEO; GSM1214587
GEO; GSM1238128
GEO; GSM1264068
GEO; GSM1264073
GEO; GSM1264110
GEO; GSM1264115
GEO; GSM1374408
GEO; GSM1374409
GEO; GSM1374410
GEO; GSM1401649
GEO; GSM1669630
GEO; GSM2176271
GEO; GSM2176272
Polymorphism and mutation databases Cosmic; 687464
Cosmic; 871138
Cosmic; 904351
Cosmic; 923058
Cosmic; 934520
Cosmic; 946359
Cosmic; 970088
Cosmic; 979721
Cosmic; 1000122
Cosmic; 1017168
Cosmic; 1018460
Cosmic; 1046934
Cosmic; 1047699
Cosmic; 1071903
Cosmic; 1129654
Cosmic; 1136353
Cosmic; 1176605
Cosmic; 1287890
Cosmic; 1289383
Cosmic; 1308996
Cosmic; 1434947
Cosmic; 1523771
Cosmic; 1603191
Cosmic; 1609475
Cosmic; 1945863
Cosmic; 2165003
Cosmic; 2301523
Cosmic; 2318376
Cosmic; 2361356
IARC_TP53; 4
LiGeA; CCLE_516
Progenetix; CVCL_0179
Proteomic databases PRIDE; PXD002281
PRIDE; PXD002635
PRIDE; PXD004357
PRIDE; PXD005390
PRIDE; PXD008222
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number48