Cell line name |
BT474-LAPRa |
Accession |
CVCL_EI02 |
Resource Identification Initiative |
To cite this cell line use: BT474-LAPRa (RRID:CVCL_EI02) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_49603; Lapatinib (Tykerb; Tyverb). Derived from site: In situ; Breast; UBERON=UBERON_0000310. |
Sequence variations |
- Gene fusion; HGNC; HGNC:24618; AHCTF1 + HGNC; HGNC:736; NAAA; Name(s)=AHCTF1-NAAA (from parent cell line).
- Gene fusion; HGNC; HGNC:16173; DOK5 + HGNC; HGNC:17579; STARD3; Name(s)=STARD3-DOK5 (from parent cell line).
- Gene fusion; HGNC; HGNC:13178; IKZF3 + HGNC; HGNC:12649; VAPB; Name(s)=VAPB-IKZF3 (from parent cell line).
- Gene fusion; HGNC; HGNC:16651; MRPL45 + HGNC; HGNC:16181; TRPC4AP; Name(s)=TRPC4AP-MRPL45 (from parent cell line).
- Gene fusion; HGNC; HGNC:7609; MYO9B + HGNC; HGNC:9764; RAB22A; Name(s)=RAB22A-MYO9B (from parent cell line).
- Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ser3094Ter (c.9281C>A); ClinVar=VCV000188440; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11621; HNF1A; Simple; p.Gln495Ter (c.1483C>T); ClinVar=VCV000586785; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6871; MAPK1; Simple; p.His61Gln (c.183C>G); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Lys111Asn (c.333G>C); ClinVar=VCV000376483; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
|
Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0179 (BT-474) |
Sex of cell |
Female |
Age at sampling |
60Y |
Category |
Cancer cell line |
Publications | PubMed=26883193; DOI=10.18632/oncotarget.7317; PMCID=PMC4905492 Helen Creedon, Laura Gomez-Cuadrado, Zygimante Tarnauskaite, Jozef Balla, Marta Canel, Kenneth G. MacLeod, Bryan Serrels, Craig Fraser, Asier Unciti-Broceta, Natasha Tracey, Thierry Le Bihan ...Show all 15 authors... , Teresa Klinowska, Andrew H. Sims, Adam Byron, Valerie G. Brunton; Show fewer authors Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy. Oncotarget 7:11539-11552(2016) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_EI02
|
Encyclopedic resources |
Wikidata; Q54798494
|
Entry history |
Entry creation | 13-Jul-2016 |
Last entry update | 10-Apr-2025 |
Version number | 15 |
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