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Cellosaurus BT474-LR (CVCL_VL01)

[Text version]
Cell line name BT474-LR
Synonyms BT474/LR; BT474 LR
Accession CVCL_VL01
Resource Identification Initiative To cite this cell line use: BT474-LR (RRID:CVCL_VL01)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_49603; Lapatinib (Tykerb; Tyverb).
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Gene fusion; HGNC; HGNC:24618; AHCTF1 + HGNC; HGNC:736; NAAA; Name(s)=AHCTF1-NAAA (from parent cell line).
  • Gene fusion; HGNC; HGNC:16173; DOK5 + HGNC; HGNC:17579; STARD3; Name(s)=STARD3-DOK5 (from parent cell line).
  • Gene fusion; HGNC; HGNC:13178; IKZF3 + HGNC; HGNC:12649; VAPB; Name(s)=VAPB-IKZF3 (from parent cell line).
  • Gene fusion; HGNC; HGNC:16651; MRPL45 + HGNC; HGNC:16181; TRPC4AP; Name(s)=TRPC4AP-MRPL45 (from parent cell line).
  • Gene fusion; HGNC; HGNC:7609; MYO9B + HGNC; HGNC:9764; RAB22A; Name(s)=RAB22A-MYO9B (from parent cell line).
  • Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ser3094Ter (c.9281C>A); ClinVar=VCV000188440; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11621; HNF1A; Simple; p.Gln495Ter (c.1483C>T); ClinVar=VCV000586785; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6871; MAPK1; Simple; p.His61Gln (c.183C>G); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Lys111Asn (c.333G>C); ClinVar=VCV000376483; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0179 (BT-474)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
Publications

PubMed=25590338; DOI=10.4161/15384101.2014.994966; PMCID=PMC4614407
Canfield K., Li J.-Q., Wilkins O.M., Morrison M.M., Ung M., Wells W., Williams C.R., Liby K.T., Vullhorst D., Buonanno A., Hu H.-Z., Schiff R., Cook R.S., Kurokawa M.
Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells.
Cell Cycle 14:648-655(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VL01
Anatomy/cell type resources BTO; BTO_0006065
Encyclopedic resources Wikidata; Q93432846
Entry history
Entry creation07-Sep-2018
Last entry update10-Apr-2025
Version number10