Cell line name |
BT-474 EEI |
Synonyms |
BT474-EEI; BT474 EEI; BT-474 Exogenous Estrogen Independent |
Accession |
CVCL_AR96 |
Resource Identification Initiative |
To cite this cell line use: BT-474 EEI (RRID:CVCL_AR96) |
Comments |
Population: Caucasian. Derived from site: In situ; Breast; UBERON=UBERON_0000310. |
Sequence variations |
- Gene fusion; HGNC; HGNC:24618; AHCTF1 + HGNC; HGNC:736; NAAA; Name(s)=AHCTF1-NAAA (from parent cell line).
- Gene fusion; HGNC; HGNC:16173; DOK5 + HGNC; HGNC:17579; STARD3; Name(s)=STARD3-DOK5 (from parent cell line).
- Gene fusion; HGNC; HGNC:13178; IKZF3 + HGNC; HGNC:12649; VAPB; Name(s)=VAPB-IKZF3 (from parent cell line).
- Gene fusion; HGNC; HGNC:16651; MRPL45 + HGNC; HGNC:16181; TRPC4AP; Name(s)=TRPC4AP-MRPL45 (from parent cell line).
- Gene fusion; HGNC; HGNC:7609; MYO9B + HGNC; HGNC:9764; RAB22A; Name(s)=RAB22A-MYO9B (from parent cell line).
- Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ser3094Ter (c.9281C>A); ClinVar=VCV000188440; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11621; HNF1A; Simple; p.Gln495Ter (c.1483C>T); ClinVar=VCV000586785; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6871; MAPK1; Simple; p.His61Gln (c.183C>G); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Lys111Asn (c.333G>C); ClinVar=VCV000376483; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
|
Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0179 (BT-474) |
Sex of cell |
Female |
Age at sampling |
60Y |
Category |
Cancer cell line |
Publications | PubMed=19010901; DOI=10.1158/0008-5472.CAN-08-1776 Gail D. Lewis Phillips, Guang-Min Li, Debra L. Dugger, Lisa M. Crocker, Kathryn L. Parsons, Elaine Mai, Walter A. Blattler, John M. Lambert, Ravi V.J. Chari, Robert J. Lutz, Wai Lee T. Wong ...Show all 17 authors... , Frederic S. Jacobson, Hartmut Koeppen, Ralph H. Schwall, Sara R. Kenkare-Mitra, Susan D. Spencer, Mark X. Sliwkowski; Show fewer authors Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res. 68:9280-9290(2008) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_AR96
|
Encyclopedic resources |
Wikidata; Q54798463
|
Entry history |
Entry creation | 02-May-2016 |
Last entry update | 10-Apr-2025 |
Version number | 14 |
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