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Cellosaurus A-172 (CVCL_0131)

[Text version]
Cell line name A-172
Synonyms A172; A 172; A-172 MG; A-172MG
Accession CVCL_0131
Resource Identification Initiative To cite this cell line use: A-172 (RRID:CVCL_0131)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Part of: PTEN genetic alteration cell panel (ATCC TCP-1030).
Population: Caucasian.
Doubling time: 44 hours (PubMed=9842975); 40 hours (PubMed=25984343); 33-48 hours (PubMed=30188626); ~45 hours (Note=Lot 021999), ~30 hours (Note=Lot 06092006), ~42 hours (Note=Lot 06262015), ~26 hours (Note=Lot 12192018) (JCRB=JCRB0228).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
HLA typing Source: PubMed=77569
Class I
HLA-AA*01,02
HLA-BB*07,08

Source: PubMed=26589293
Class I
HLA-AA*01:01,03:01
HLA-BB*07:02,08:01
HLA-CC*07:01,07:01
Class II
HLA-DQDQB1*06:07,06:07
HLA-DRDRB1*11:26,13:09

Source: CLS=300108
Class I
HLA-AA*01:01:01,03:01:01
HLA-BB*07:02:01,08:01:01
HLA-CC*07:01:01,07:02:01
Class II
HLA-DPDPB1*02:01:02G,04:02:01G
HLA-DQDQA1*05:01,05:05
DQB1*02:01,03:01
HLA-DRDRB1*03:01,11:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North2.05
East Asian, South0
South Asian1.21
European, North68.98
European, South27.77
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D5ZN (A172/TMZ)CVCL_5735 (D-54MG)CVCL_D6AE (HyCyte A-172 KO-hTP53)
CVCL_E3GJ (HyCyte A-172-Luc)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0005009/5018; ATCC=CRL-1620; CLS=300108; Cosmic-CLP=687563; ECACC=88062428; IZSLER=BS TCL 2; JCRB=JCRB0228; KCLB=21620; PubMed=17254797; PubMed=22570425; PubMed=25877200; RCB=RCB2530; Technion Genomics Center; TKG=TKG 0183

Markers:
AmelogeninX,Y
CSF1PO9,11 (PubMed=17254797)
9,12 (AddexBio=C0005009/5018; ATCC=CRL-1620; CLS=300108; Cosmic-CLP=687563; ECACC=88062428; IZSLER=BS TCL 2; JCRB=JCRB0228; KCLB=21620; PubMed=22570425; PubMed=25877200; RCB=RCB2530; Technion Genomics Center; TKG=TKG 0183)
D1S165612,14
D2S44110,11
D2S133820,21
D3S135814,18 (ATCC=CRL-1620; CLS=300108; PubMed=22570425; PubMed=25877200; Technion Genomics Center)
15,18 (PubMed=17254797)
D5S81811,12
D6S104313,18
D7S82011
D8S117913,14
D10S124815
D12S39122
D13S31711
D16S53911 (PubMed=17254797)
12 (AddexBio=C0005009/5018; ATCC=CRL-1620; CLS=300108; Cosmic-CLP=687563; ECACC=88062428; IZSLER=BS TCL 2; JCRB=JCRB0228; KCLB=21620; PubMed=22570425; PubMed=25877200; RCB=RCB2530; Technion Genomics Center; TKG=TKG 0183)
D18S5112,13
D19S43312,15.2
D21S1127,32 (PubMed=17254797)
28,32.2 (ATCC=CRL-1620; CLS=300108; IZSLER=BS TCL 2; PubMed=22570425; PubMed=25877200; Technion Genomics Center)
D22S104516
DYS39111
FGA20,22
Penta D9,13
Penta E5,10
TH016,9.3 (AddexBio=C0005009/5018; ATCC=CRL-1620; CLS=300108; Cosmic-CLP=687563; ECACC=88062428; IZSLER=BS TCL 2; KCLB=21620; PubMed=22570425; PubMed=25877200; RCB=RCB2530; Technion Genomics Center; TKG=TKG 0183)
6,10 (JCRB=JCRB0228; PubMed=17254797)
TPOX8,11
vWA17,20 (RCB=RCB2530)
20 (AddexBio=C0005009/5018; ATCC=CRL-1620; CLS=300108; Cosmic-CLP=687563; ECACC=88062428; IZSLER=BS TCL 2; JCRB=JCRB0228; KCLB=21620; PubMed=17254797; PubMed=22570425; PubMed=25877200; Technion Genomics Center; TKG=TKG 0183)

Run an STR similarity search on this cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/a/cell-lines-detail-280.html
Publications

PubMed=4357758; DOI=10.1093/jnci/51.5.1417
Donald J. Giard, Stuart A. Aaronson, George J. Todaro, Paul Arnstein, John H. Kersey, Harvey Dosik, Wade P. Parks;
In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.
J. Natl. Cancer Inst. 51:1417-1423(1973)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=77569; DOI=10.1111/j.1399-0039.1978.tb01259.x
Jons Ake Espmark, Lena Ahlqvist-Roth, Lena Sarne, Anita Persson;
Tissue typing of cells in culture. III. HLA antigens of established human cell lines. Attempts at typing by the mixed hemadsorption technique.
Tissue Antigens 11:279-286(1978)

PubMed=212188
George J. Todaro, Joseph E. De Larco;
Growth factors produced by sarcoma virus-transformed cells.
Cancer Res. 38:4147-4154(1978)

PubMed=450131; DOI=10.1038/279797a0
Rufus S. Day 3rd, Chuck H.J. Ziolkowski;
Human brain tumour cell strains with deficient host-cell reactivation of N-methyl-N'-nitro-N-nitrosoguanidine-damaged adenovirus 5.
Nature 279:797-799(1979)

PubMed=6256643; DOI=10.1038/288724a0
Rufus S. Day 3rd, Chuck H.J. Ziolkowski, Dominic A. Scudiero, Sharon A. Meyer, Anthony S. Lubiniecki, Anthony Joseph Girardi, Sheila Margaret Galloway, Gaither D. Bynum;
Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains.
Nature 288:724-727(1980)

PubMed=6260907; DOI=10.1097/00005072-198105000-00001
Darell Doty Bigner, Sandra H. Bigner, Jan Ponten, Bengt Westermark, Moses Stephen Mahaley Jr., Erkki Ruoslahti, Harvey R. Herschman, Lawrence F. Eng, Carol J. Wikstrand;
Heterogeneity of genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas.
J. Neuropathol. Exp. Neurol. 40:201-229(1981)

PubMed=6954533; DOI=10.1073/pnas.79.7.2194; PMCID=PMC346157
Eric H. Westin, Robert Charles Gallo, Suresh K. Arya, Alessandra Eva, Lawrence M. Souza, Marcel Albert Baluda, Stuart A. Aaronson, Flossie Wong-Staal;
Differential expression of the amv gene in human hematopoietic cells.
Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982)

PubMed=6220172
Nicholas C. Dracopoli, Jorgen Fogh;
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=6652614; DOI=10.1016/0165-4608(83)90091-2
Sandra H. Bigner, Joachim Mark, Darell Doty Bigner;
Chromosomal composition of four permanent cultured cell lines derived from human gliomas.
Cancer Genet. Cytogenet. 10:335-349(1983)

PubMed=6825208; DOI=10.1093/carcin/4.2.199
Daniel B. Yarosh, Robert S. Foote, Sankar Mitra, Rufus S. Day 3rd;
Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains.
Carcinogenesis 4:199-205(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3759084; DOI=10.1007/BF00278796
Wolfram Henn, Nikolaus Blin, Klaus-Dieter Zang;
Polysomy of chromosome 7 is correlated with overexpression of the erbB oncogene in human glioblastoma cell lines.
Hum. Genet. 74:104-106(1986)

PubMed=3675803
Sandra H. Bigner, Rolf Bjerkvig, Ole Didrik Laerum, Laurence H. Muhlbaier, Darell Doty Bigner;
DNA content and chromosomes in permanent cultured cell lines derived from malignant human gliomas.
Anal. Quant. Cytol. Histol. 9:435-444(1987)

PubMed=1385192; DOI=10.1016/0531-5565(92)90007-m
Timothy P. Fleming, Toshimitsu Matsui, Stuart A. Aaronson;
Platelet-derived growth factor (PDGF) receptor activation in cell transformation and human malignancy.
Exp. Gerontol. 27:523-532(1992)

DOI=10.1016/B978-0-12-333530-2.50005-8
Monica Nister, Bengt Westermark;
Human glioma cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.17-42; Academic Press; New York; USA (1994)

PubMed=7523863; DOI=10.1128/mcb.14.11.7604-7610.1994; PMCID=PMC359296
Helen M. Pomykala, Stefan Klaus Bohlander, Pamela L. Broeker, Olufunmilayo I. Olopade, Manuel O. Diaz;
Breakpoint junctions of chromosome 9p deletions in two human glioma cell lines.
Mol. Cell. Biol. 14:7604-7610(1994)

PubMed=9090379; DOI=10.1038/ng0497-356
Peter A. Steck, Mark A. Pershouse, Samar A. Jasser, Wai-Kwan Alfred Yung, Huai Lin, Azra Hadi Ligon, Lauren A. Langford, Michelle L. Baumgard, Thomas Hattier, Thaylon Davis, Cheryl Frye ...Show all 15 authors... , Rong Hu, Bradley Swedlund, David H.-F. Teng, Sean V. Tavtigian; Show fewer authors
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.
Nat. Genet. 15:356-362(1997)

PubMed=9220028; DOI=10.1016/S0303-7207(97)00080-4
Taraneh R. Sharif, Wei Luo, Mohammed Sharif;
Functional expression of bombesin receptor in most adult and pediatric human glioblastoma cell lines; role in mitogenesis and in stimulating the mitogen-activated protein kinase pathway.
Mol. Cell. Endocrinol. 130:119-130(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9842975; DOI=10.1002/(SICI)1097-0215(19981218)79:6<640::AID-IJC15>3.0.CO;2-Z
Michael Weller, Johannes Rieger, Cornelia Grimmel, Erwin G. Van Meir, Nicolas De Tribolet, Stanislaw Krajewski, John C. Reed, Andreas von Deimling, Johannes Dichgans;
Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses.
Int. J. Cancer 79:640-644(1998)

DOI=10.1007/0-306-46861-1_11
Francis Ali-Osman;
Brain tumors.
(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999)

PubMed=10402232; DOI=10.3892/ijo.15.2.237
Taraneh R. Sharif, Mohammed Sharif;
Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples.
Int. J. Oncol. 15:237-243(1999)

PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x; PMCID=PMC8098486
Nobuaki Ishii, Daniel Maier, Adrian Merlo, Mitsuhiro Tada, Yutaka Sawamura, Annie-Claire Diserens, Erwin G. Van Meir;
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.
Brain Pathol. 9:469-479(1999)

PubMed=10698499; DOI=10.1038/sj.onc.1203409
Michael J. Ciesielski, Robert A. Fenstermaker;
Oncogenic epidermal growth factor receptor mutants with tandem duplication: gene structure and effects on receptor function.
Oncogene 19:810-820(2000)

PubMed=11351043; DOI=10.1038/labinvest.3780280
Angela Bik-Yu Hui, Kwok-Wai Lo, Xiao-Lu Yin, Wai-Sang Poon, Ho-Keung Ng;
Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization.
Lab. Invest. 81:717-723(2001)

PubMed=14614447; DOI=10.1038/sj.onc.1207198
Jorg Wischhusen, Ulrike Naumann, Hiroko Ohgaki, Farzan Rastinejad, Michael Weller;
CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death.
Oncogene 22:8233-8245(2003)

PubMed=14655754; DOI=10.1111/j.1750-3639.2003.tb00479.x; PMCID=PMC8095903
Oliver Bahr, Johannes Rieger, Frank Duffner, Richard Meyermann, Michael Weller, Wolfgang Wick;
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
Brain Pathol. 13:482-494(2003)

PubMed=15900046; DOI=10.1093/jnci/dji133
Tetsuo Mashima, Tomoko Oh-hara, Shigeo Sato, Mikiko Mochizuki, Yoshikazu Sugimoto, Kanami Yamazaki, Jun-ichi Hamada, Mitsuhiro Tada, Tetsuya Moriuchi, Yuichi Ishikawa, Yo Kato ...Show all 14 authors... , Hiroshi Tomoda, Takao Yamori, Takashi Tsuruo; Show fewer authors
p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
J. Natl. Cancer Inst. 97:765-777(2005)

PubMed=16232199; DOI=10.1111/j.1349-7006.2005.00099.x; PMCID=PMC11159392
Kuniyasu Saigusa, Naoya Hashimoto, Hitoshi Tsuda, Sana Yokoi, Motohiko Maruno, Toshiki Yoshimine, Masaru Aoyagi, Kikuo Ohno, Issei Imoto, Johji Inazawa;
Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.
Cancer Sci. 96:676-683(2005)

PubMed=16697959; DOI=10.1016/j.ccr.2006.03.030
Jeongwu Lee, Svetlana Kotliarova, Yuri Kotliarov, Ai-Guo Li, Qin Su, Nicholas Murray Donin, Sandra Pastorino, Benjamin W. Purow, Neil Christopher, Wei Zhang, John K. Park, Howard Alan Fine;
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.
Cancer Cell 9:391-403(2006)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Shahram Azari, Nahid Ahmadi, Mahmood Jeddi-Tehrani, Fazel Shokri;
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=17595512; DOI=10.1159/000104150
Johannes Rieger, Brigitte Frank, Michael Weller, Wolfgang Wick;
Mechanisms of resistance of human glioma cells to Apo2 ligand/TNF-related apoptosis-inducing ligand.
Cell. Physiol. Biochem. 20:23-34(2007)

PubMed=19365568; DOI=10.1371/journal.pone.0005209; PMCID=PMC2666263
Dorine Arjanne Bax, Suzanne E. Little, Nathalie Gaspar, Lara Perryman, Lynley Marshall, Marta Viana-Pereira, Tania A. Jones, Richard D. Williams, Anita Grigoriadis, Gilles Vassal, Paul Workman ...Show all 16 authors... , Denise Sheer, Rui Manuel Reis, Andrew D.J. Pearson, Darren Hargrave, Chris Jones; Show fewer authors
Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.
PLoS ONE 4:e5209.1-e5209.9(2009)

PubMed=19435942; DOI=10.1215/15228517-2009-025; PMCID=PMC2743214
Koichi Ichimura, Danita M. Pearson, Sylvia Kocialkowski, L. Magnus Backlund, Raymond Chan, David T.W. Jones, Vincent Peter Collins;
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.
Neuro-oncol. 11:341-347(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21406405; DOI=10.1158/0008-5472.CAN-10-3112
Michal Grzmil, Pier Morin Jr., Maria Maddalena Lino, Adrian Merlo, Stephan Frank, Yu-Hua Wang, Gerald Moncayo, Brian Arthur Hemmings;
MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-beta signaling pathway in human glioblastoma.
Cancer Res. 71:2392-2402(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22570425; DOI=10.1093/neuonc/nos072; PMCID=PMC3367844
Pierre Bady, Annie-Claire Diserens, Vincent Castella, Stefanie Kalt, Karl Heinimann, Marie-France Hamou, Mauro Delorenzi, Monika E. Hegi;
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Neuro-oncol. 14:701-711(2012)

PubMed=23637631; DOI=10.1371/journal.pgen.1003464; PMCID=PMC3636093
Craig P. Giacomini, Steven Sun, Sushama Varma, Alan Hunter Shain, Marilyn M. Giacomini, Jay Michael S. Balagtas, Robert T. Sweeney, Everett Lai, Catherine A. Del Vecchio, Andrew D. Forster, Nicole Clarke ...Show all 17 authors... , Kelli D. Montgomery, Shirley Zhu, Albert J. Wong, Matt van de Rijn, Robert B. West, Jonathan R. Pollack; Show fewer authors
Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types.
PLoS Genet. 9:e1003464.1-e1003464.19(2013)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30188626; DOI=10.1134/S1990519X16050072
Liubov Nikolaevna Kiseleva, Artem Vladimirovich Kartashev, Natalia Levonovna Vartanyan, Agniia Aleksandrovna Pinevich, Marina Platonovna Samoylovich;
Characteristics of A172 and T98G cell lines.
Tsitologiia 58:349-355(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
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Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
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Nature 568:511-516(2019)

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lncRNA TUG1 inhibits the cancer stem cell-like properties of temozolomide-resistant glioma cells by interacting with EZH2.
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Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) AddexBio; C0005009/5018
ATCC; CRL-1620
ATCC; CRL-7899 - Discontinued
CLS; 300108
ECACC; 88062428
ICLC; HTL97013
IZSLER; BS TCL 2
JCRB; JCRB0228
KCB; KCB 200966YJ
KCLB; 21620
NCBI_Iran; C211
RCB; RCB2530
TKG; TKG 0183
Cell line databases/resources CLO; CLO_0001543
CLO; CLO_0001559
CLO; CLO_0001560
CLO; CLO_0050637
MCCL; MCC:0000023
CLDB; cl142
CLDB; cl143
CLDB; cl144
CLDB; cl146
cancercelllines; CVCL_0131
CCRID; 3101HUMTCHu171
Cell_Model_Passport; SIDM00799
CGH-DB; 138-1
Cosmic-CLP; 687563
DepMap; ACH-000558
IGRhCellID; A172
LINCS_LDP; LCL-1348
Lonza; 178
Anatomy/cell type resources BTO; BTO_0000016
Biological sample resources BioSample; SAMN03471115
BioSample; SAMN03471212
BioSample; SAMN03471659
BioSample; SAMN03471918
BioSample; SAMN10988258
ENCODE; ENCBS225AJI
ENCODE; ENCBS874LTK
CRISP screens repositories BioGRID_ORCS_Cell_line; 823
Chemistry resources ChEMBL-Cells; CHEMBL3308491
ChEMBL-Targets; CHEMBL614512
GDSC; 687563
PharmacoDB; A172_36_2019
PubChem_Cell_line; CVCL_0131
Encyclopedic resources Wikidata; Q54605968
Experimental variables resources EFO; EFO_0002101
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10444-106F3
GEO; GSM101609
GEO; GSM101610
GEO; GSM326244
GEO; GSM886850
GEO; GSM887914
GEO; GSM1374378
GEO; GSM1669577
Polymorphism and mutation databases Cosmic; 687563
Cosmic; 849883
Cosmic; 897446
Cosmic; 1014068
Cosmic; 1036334
Cosmic; 1066233
Cosmic; 1171223
Cosmic; 1236360
Cosmic; 1610751
Cosmic; 1746956
Cosmic; 1995327
Cosmic; 2302321
Cosmic; 2367506
Cosmic; 2516012
IARC_TP53; 21157
LiGeA; CCLE_757
Progenetix; CVCL_0131
Proteomic databases PRIDE; PXD001110
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number50