Cellosaurus logo
expasy logo

Cellosaurus MOC2 (CVCL_ZD33)

[Text version]
Cell line name MOC2
Synonyms Mouse Oral Cancer 2
Accession CVCL_ZD33
Resource Identification Initiative To cite this cell line use: MOC2 (RRID:CVCL_ZD33)
Comments Characteristics: Agressive growth phenotype.
Transformant: ChEBI; CHEBI_254496; 7,12-dimethyltetraphene (DMBA; dimethylbenzanthracene).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Sequence variations
  • Mutation; MGI; MGI:96680; Kras; Simple; p.Gln61His (c.183A>T); Zygosity=Unspecified (PubMed=22086849).
  • Mutation; MGI; MGI:98834; Trp53; Simple; p.Glu225Ter; Zygosity=Unspecified (PubMed=24668645).
Disease Squamous cell carcinoma of the mouse oral cavity (NCIt: C23049)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6 Cxcr3-/-.
Hierarchy Children:
CVCL_ZD34 (MOC2-7)CVCL_ZD35 (MOC2-10)
Originate from same individual CVCL_ZD38 ! MOC2LN
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Kerafast=EWL002-FP; Millipore=SCC470

Markers:
Mouse STR 1-116
Mouse STR 1-218,19
Mouse STR 2-116
Mouse STR 3-214
Mouse STR 4-220.3
Mouse STR 5-517
Mouse STR 6-418
Mouse STR 6-715 (Kerafast=EWL002-FP)
15,16 (Millipore=SCC470)
Mouse STR 7-126.2
Mouse STR 8-116
Mouse STR 11-216
Mouse STR 12-117
Mouse STR 13-117
Mouse STR 15-322.3,23.3
Mouse STR 17-215
Mouse STR 18-317
Mouse STR 19-213
Mouse STR X-126

Run an STR similarity search on this cell line
Web pages Provider; AHNS; -; https://www.ahns.info/view/research-cell-lines-view/entry/24334/
Publications

PubMed=22086849; DOI=10.1158/0008-5472.CAN-11-1831; PMCID=PMC3286642
Nancy P. Judd, Ashley E. Winkler, Oihana Murillo-Sauca, Joshua J. Brotman, Jonathan H. Law, James S. Lewis Jr., Gavin P. Dunn, Jack D. Bui, John B. Sunwoo, Ravindra Uppaluri;
ERK1/2 regulation of CD44 modulates oral cancer aggressiveness.
Cancer Res. 72:365-374(2012)

PubMed=22434099; DOI=10.1177/0194599812442037; PMCID=PMC6346425
Nancy P. Judd, Clint Tanner Allen, Ashley E. Winkler, Ravindra Uppaluri;
Comparative analysis of tumor-infiltrating lymphocytes in a syngeneic mouse model of oral cancer.
Otolaryngol. Head Neck Surg. 147:493-500(2012)

PubMed=24668645; DOI=10.1158/1078-0432.CCR-14-0205; PMCID=PMC4096804
Michael D. Onken, Ashley E. Winkler, Krishna-Latha Kanchi, Varun Chalivendra, Jonathan H. Law, Charles G. Rickert, Dorina Kallogjeri, Nancy P. Judd, Gavin P. Dunn, Jay Francis Piccirillo, James S. Lewis Jr. ...Show all 13 authors... , Elaine R. Mardis, Ravindra Uppaluri; Show fewer authors
A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease.
Clin. Cancer Res. 20:2873-2884(2014)

PubMed=25729643; DOI=10.1016/j.gdata.2014.11.006; PMCID=PMC4340082
Varun Chalivendra, Krishna-Latha Kanchi, Michael D. Onken, Ashley E. Winkler, Elaine R. Mardis, Ravindra Uppaluri;
Genomic analysis to define molecular basis of aggressiveness in a mouse model of oral cancer.
Genom. Data 3:61-62(2015)

Cross-references
Cell line collections (Providers) Kerafast; EWL002-FP
Millipore; SCC470
Encyclopedic resources Wikidata; Q98127271
Gene expression databases GEO; GSM1213080
GEO; GSM1213081
GEO; GSM1213082
Entry history
Entry creation02-Jul-2020
Last entry update10-Apr-2025
Version number9