Cellosaurus cell line MOC2-10 (CVCL

Cellosaurus MOC2-10 (CVCL_ZD35)

Cross-references
Cell line name	MOC2-10
Synonyms	MOC10; Mouse Oral Cancer 10
Accession	CVCL_ZD35
Resource Identification Initiative	To cite this cell line use: MOC2-10 (RRID:CVCL_ZD35)
Comments	Problematic cell line: Contaminated. Shown to be a MOC2 derivative (PubMed=24668645). Originally (PubMed=22086849) thought to be independently derived and was named MOC10. Was renamed MOC2-10 when shown to be a derivative of MOC2. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00594. Transformant: ChEBI; CHEBI_254496; 7,12-dimethyltetraphene (DMBA; dimethylbenzanthracene). Omics: Genomics; Whole exome sequencing. Omics: Transcriptomics; Microarray.
Sequence variations	Mutation; MGI; MGI:96680; Kras; Simple; p.Gln61His (c.183A>T); Zygosity=Unspecified (PubMed=22086849). Mutation; MGI; MGI:98834; Trp53; Simple; p.Glu225Ter; Zygosity=Unspecified (PubMed=24668645).
Disease	Squamous cell carcinoma of the mouse oral cavity (NCIt: C23049)
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: C57BL/6 Cxcr3-/-.
Hierarchy	Parent: CVCL_ZD33 (MOC2)
Sex of cell	Female
Category	Cancer cell line
Web pages	Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications	PubMed=22086849; DOI=10.1158/0008-5472.CAN-11-1831; PMCID=PMC3286642 Nancy P. Judd, Ashley E. Winkler, Oihana Murillo-Sauca, Joshua J. Brotman, Jonathan H. Law, James S. Lewis Jr., Gavin P. Dunn, Jack D. Bui, John B. Sunwoo, Ravindra Uppaluri; ERK1/2 regulation of CD44 modulates oral cancer aggressiveness. Cancer Res. 72:365-374(2012) PubMed=24668645; DOI=10.1158/1078-0432.CCR-14-0205; PMCID=PMC4096804 Michael D. Onken, Ashley E. Winkler, Krishna-Latha Kanchi, Varun Chalivendra, Jonathan H. Law, Charles G. Rickert, Dorina Kallogjeri, Nancy P. Judd, Gavin P. Dunn, Jay Francis Piccirillo, James S. Lewis Jr. ...Show all 13 authors... , Elaine R. Mardis, Ravindra Uppaluri; Show fewer authors A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease. Clin. Cancer Res. 20:2873-2884(2014) PubMed=25729643; DOI=10.1016/j.gdata.2014.11.006; PMCID=PMC4340082 Varun Chalivendra, Krishna-Latha Kanchi, Michael D. Onken, Ashley E. Winkler, Elaine R. Mardis, Ravindra Uppaluri; Genomic analysis to define molecular basis of aggressiveness in a mouse model of oral cancer. Genom. Data 3:61-62(2015)
Encyclopedic resources	Wikidata; Q98127274
Gene expression databases	GEO; GSM1213086 GEO; GSM1213087 GEO; GSM1213088
Entry history
Entry creation	02-Jul-2020
Last entry update	10-Apr-2025
Version number	9