ID   MOC2-10
AC   CVCL_ZD35
SY   MOC10; Mouse Oral Cancer 10
DR   GEO; GSM1213086
DR   GEO; GSM1213087
DR   GEO; GSM1213088
DR   Wikidata; Q98127274
RX   PubMed=22086849;
RX   PubMed=24668645;
RX   PubMed=25729643;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a MOC2 derivative (PubMed=24668645). Originally (PubMed=22086849) thought to be independently derived and was named MOC10. Was renamed MOC2-10 when shown to be a derivative of MOC2.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00594.
CC   Sequence variation: Mutation; MGI; MGI:96680; Kras; Simple; p.Gln61His (c.183A>T); Zygosity=Unspecified (PubMed=22086849).
CC   Sequence variation: Mutation; MGI; MGI:98834; Trp53; Simple; p.Glu225Ter; Zygosity=Unspecified (PubMed=24668645).
CC   Transformant: ChEBI; CHEBI_254496; 7,12-dimethyltetraphene (DMBA; dimethylbenzanthracene).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Breed/subspecies: C57BL/6 Cxcr3-/-.
DI   NCIt; C23049; Squamous cell carcinoma of the mouse oral cavity
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_ZD33 ! MOC2
SX   Female
CA   Cancer cell line
DT   Created: 02-07-20; Last updated: 10-04-25; Version: 9
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RX   PubMed=22086849; DOI=10.1158/0008-5472.CAN-11-1831; PMCID=PMC3286642;
RA   Judd N.P., Winkler A.E., Murillo-Sauca O., Brotman J.J., Law J.H.,
RA   Lewis J.S. Jr., Dunn G.P., Bui J.D., Sunwoo J.B., Uppaluri R.;
RT   "ERK1/2 regulation of CD44 modulates oral cancer aggressiveness.";
RL   Cancer Res. 72:365-374(2012).
//
RX   PubMed=24668645; DOI=10.1158/1078-0432.CCR-14-0205; PMCID=PMC4096804;
RA   Onken M.D., Winkler A.E., Kanchi K.-L., Chalivendra V., Law J.H.,
RA   Rickert C.G., Kallogjeri D., Judd N.P., Dunn G.P., Piccirillo J.F.,
RA   Lewis J.S. Jr., Mardis E.R., Uppaluri R.;
RT   "A surprising cross-species conservation in the genomic landscape of
RT   mouse and human oral cancer identifies a transcriptional signature
RT   predicting metastatic disease.";
RL   Clin. Cancer Res. 20:2873-2884(2014).
//
RX   PubMed=25729643; DOI=10.1016/j.gdata.2014.11.006; PMCID=PMC4340082;
RA   Chalivendra V., Kanchi K.-L., Onken M.D., Winkler A.E., Mardis E.R.,
RA   Uppaluri R.;
RT   "Genomic analysis to define molecular basis of aggressiveness in a
RT   mouse model of oral cancer.";
RL   Genom. Data 3:61-62(2015).
//