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Cellosaurus ARD (CVCL_XD83)

[Text version]
Cell line name ARD
Synonyms ard-1
Accession CVCL_XD83
Resource Identification Initiative To cite this cell line use: ARD (RRID:CVCL_XD83)
Comments From: Epstein J.; Myeloma and Transplantation Research Center, Arkansas Cancer Research Center; Little Rock; USA.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene deletion; HGNC; 12637; KDM6A; Zygosity=Homozygous (PubMed=29045832).
  • Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5732; IGKV1-16; Name(s)=IGKV1-16-IGKJ4 (CelloPub=CLPUB00604).
  • Gene fusion; HGNC; 5723; IGKJ5 + HGNC; 5732; IGKV1-16; Name(s)=IGKV1-16-IGKJ5 (CelloPub=CLPUB00604).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A5RY (ARD-EZH2i-R)CVCL_A5RZ (ARD-pUTX)
Originate from same individual CVCL_D523 ! ARP-1
CVCL_D569 ! CAG
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): CCRID

Markers:
AmelogeninX
CSF1PO11,12
D2S133820,21
D3S135815,18
D5S81812,13
D6S104319
D7S82010,12
D8S117910,13
D12S39118.3,22
D13S3179,14
D16S53911,12
D18S5115
D19S43313,14
D21S1128,31.2
FGA18,19,24
Penta E7,15
TH016,7
TPOX11,12
vWA14,18

Run an STR similarity search on this cell line
Web pages https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
Publications

PubMed=8427968; DOI=10.1182/blood.V81.3.767.767
Ridley R.C., Xiao H.-Q., Hata H., Woodliff J., Epstein J., Sanderson R.D.
Expression of syndecan regulates human myeloma plasma cell adhesion to type I collagen.
Blood 81:767-774(1993)

DOI=10.1007/0-306-46877-8_4
Jernberg-Wiklund H., Nilsson K.
Multiple myeloma cell lines.
(In) Human cell culture. Vol. 3. Cancer Cell Lines part 3; Masters J.R.W., Palsson B.O. (eds.); pp.81-155; Kluwer Academic Publishers; New York (2000)

PubMed=14555701
Shammas M.A., Shmookler Reis R.J., Akiyama M., Koley H., Chauhan D., Hideshima T., Goyal R.K., Hurley L.H., Anderson K.C., Munshi N.C.
Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma.
Mol. Cancer Ther. 2:825-833(2003)

PubMed=14760100; DOI=10.1158/1078-0432.CCR-0793-03
Shammas M.A., Shmookler Reis R.J., Li C., Koley H., Hurley L.H., Anderson K.C., Munshi N.C.
Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma.
Clin. Cancer Res. 10:770-776(2004)

CLPUB00604
Chow S.
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017), University of Toronto, Canada

PubMed=29045832; DOI=10.1016/j.celrep.2017.09.078
Ezponda T., Dupere-Richer D., Will C.M., Small E.C., Varghese N., Patel T., Nabet B., Popovic R., Oyer J., Bulic M., Zheng Y.-P., Huang X.-X., Shah M.Y., Maji S., Riva A., Occhionorelli M., Tonon G., Kelleher N.L., Keats J.J., Licht J.D.
UTX/KDM6A loss enhances the malignant phenotype of multiple myeloma and sensitizes cells to EZH2 inhibition.
Cell Rep. 21:628-640(2017)

Cross-references
Cell line databases/resources CCRID; 1101HUM-PUMC000681
Encyclopedic resources Wikidata; Q93325829
Gene expression databases GEO; GSM2774119
GEO; GSM2774122
GEO; GSM2774124
GEO; GSM2774126
Entry history
Entry creation06-Sep-2019
Last entry update29-Jun-2023
Version number7