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Cellosaurus ARP-1 (CVCL_D523)

[Text version]
Cell line name ARP-1
Synonyms ARP1; AR-P1; ARP
Accession CVCL_D523
Resource Identification Initiative To cite this cell line use: ARP-1 (RRID:CVCL_D523)
Comments Characteristics: Produces IgA kappa.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5732; IGKV1-16; Name(s)=IGKV1-16-IGKJ4 (CelloPub=CLPUB00604).
  • Gene fusion; HGNC; 5723; IGKJ5 + HGNC; 5732; IGKV1-16; Name(s)=IGKV1-16-IGKJ5 (CelloPub=CLPUB00604).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_XD83 ! ARD
CVCL_D569 ! CAG
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Web pages https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
Publications

PubMed=7949178; DOI=10.1182/blood.V84.9.3063.3063
Hardin J., MacLeod S., Grigorieva I., Chang R.-X., Barlogie B., Xiao H.-Q., Epstein J.
Interleukin-6 prevents dexamethasone-induced myeloma cell death.
Blood 84:3063-3070(1994)

DOI=10.1007/0-306-46877-8_4
Jernberg-Wiklund H., Nilsson K.
Multiple myeloma cell lines.
(In) Human cell culture. Vol. 3. Cancer Cell Lines part 3; Masters J.R.W., Palsson B.O. (eds.); pp.81-155; Kluwer Academic Publishers; New York (2000)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Drexler H.G., Matsuo Y.
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

PubMed=14555701
Shammas M.A., Shmookler Reis R.J., Akiyama M., Koley H., Chauhan D., Hideshima T., Goyal R.K., Hurley L.H., Anderson K.C., Munshi N.C.
Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma.
Mol. Cancer Ther. 2:825-833(2003)

PubMed=14760100; DOI=10.1158/1078-0432.CCR-0793-03
Shammas M.A., Shmookler Reis R.J., Li C., Koley H., Hurley L.H., Anderson K.C., Munshi N.C.
Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma.
Clin. Cancer Res. 10:770-776(2004)

PubMed=18647998; DOI=10.1093/jncimonographs/lgn011
Dib A., Gabrea A., Glebov O.K., Bergsagel P.L., Kuehl W.M.
Characterization of MYC translocations in multiple myeloma cell lines.
J. Natl. Cancer Inst. Monogr. 39:25-31(2008)

CLPUB00604
Chow S.
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017), University of Toronto, Canada

PubMed=29045832; DOI=10.1016/j.celrep.2017.09.078
Ezponda T., Dupere-Richer D., Will C.M., Small E.C., Varghese N., Patel T., Nabet B., Popovic R., Oyer J., Bulic M., Zheng Y.-P., Huang X.-X., Shah M.Y., Maji S., Riva A., Occhionorelli M., Tonon G., Kelleher N.L., Keats J.J., Licht J.D.
UTX/KDM6A loss enhances the malignant phenotype of multiple myeloma and sensitizes cells to EZH2 inhibition.
Cell Rep. 21:628-640(2017)

Cross-references
Anatomy/cell type resources BTO; BTO:0003931
Encyclopedic resources Wikidata; Q54750549
Gene expression databases GEO; GSM2774095
GEO; GSM2774097
GEO; GSM2774129
GEO; GSM2774131
GEO; GSM2774134
GEO; GSM2774136
Polymorphism and mutation databases Cosmic; 2367264
Entry history
Entry creation22-Oct-2012
Last entry update29-Jun-2023
Version number13