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Cellosaurus ARD-pUTX (CVCL_A5RZ)

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Cell line name ARD-pUTX
Accession CVCL_A5RZ
Resource Identification Initiative To cite this cell line use: ARD-pUTX (RRID:CVCL_A5RZ)
Comments Characteristics: KDM6A/UTX expression is inducible by doxycycline (PubMed=29045832).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:12637; KDM6A.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Gene deletion; HGNC; HGNC:12637; KDM6A; Zygosity=Homozygous (PubMed=29045832).
  • Gene fusion; HGNC; HGNC:5722; IGKJ4 + HGNC; HGNC:5732; IGKV1-16; Name(s)=IGKV1-16-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; HGNC:5723; IGKJ5 + HGNC; HGNC:5732; IGKV1-16; Name(s)=IGKV1-16-IGKJ5 (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_XD83 (ARD)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=29045832; DOI=10.1016/j.celrep.2017.09.078; PMCID=PMC5706555
Teresa Ezponda, Daphne Dupere-Richer, Christine M. Will, Eliza C. Small, Nobish Varghese, Tej Patel, Behnam Nabet, Relja Popovic, Jon Oyer, Marinka Bulic, Yu-Peng Zheng ...Show all 20 authors... , Xiao-Xiao Huang, Mrinal Y. Shah, Sayantan Maji, Alberto Riva, Manuela Occhionorelli, Giovanni Tonon, Neil L. Kelleher, Jonathan J. Keats, Jonathan D. Licht; Show fewer authors
UTX/KDM6A loss enhances the malignant phenotype of multiple myeloma and sensitizes cells to EZH2 inhibition.
Cell Rep. 21:628-640(2017)

Cross-references
Encyclopedic resources Wikidata; Q107113378
Gene expression databases GEO; GSM2774100
GEO; GSM2774102
GEO; GSM2774105
GEO; GSM2774107
GEO; GSM2774110
GEO; GSM2774112
GEO; GSM2774114
GEO; GSM2774117
Entry history
Entry creation20-May-2021
Last entry update14-Aug-2025
Version number8