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Cellosaurus HBEC3-KT (CVCL_X491)

[Text version]

Cell line name HBEC3-KT
Accession CVCL_X491
Resource Identification Initiative To cite this cell line use: HBEC3-KT (RRID:CVCL_X491)
Comments Doubling time: 36-48 hours (Evercyte).
Transfected with: HGNC; 11730; TERT.
Transfected with: MGI; MGI:88357; Cdk4.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: miRNA expression profiling.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Bronchus; epithelium.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
Sex of cell Female
Age at sampling 65Y
Category Telomerase immortalized cell line
STR profile Source(s): ATCC


Run an STR similarity search on this cell line
Web pages https://evercyte.com/hbec3-kt/

PubMed=15604268; DOI=10.1158/0008-5472.CAN-04-3703
Ramirez R.D., Sheridan S., Girard L., Sato M., Kim Y., Pollack J., Peyton M., Zou Y., Kurie J.M., Dimaio J.M., Milchgrub S., Smith A.L., Souza R.F., Gilbey L., Zhang X., Gandia K., Vaughan M.B., Wright W.E., Gazdar A.F., Shay J.W., Minna J.D.
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins.
Cancer Res. 64:9027-9034(2004)

PubMed=20079948; DOI=10.1016/j.lungcan.2009.12.005
Gazdar A.F., Gao B., Minna J.D.
Lung cancer cell lines: useless artifacts or invaluable tools for medical science?
Lung Cancer 68:309-318(2010)

PubMed=20624269; DOI=10.1186/1756-9966-29-75
Du L., Schageman J.J., Irnov I., Girard L., Hammond S.M., Minna J.D., Gazdar A.F., Pertsemlidis A.
MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs.
J. Exp. Clin. Cancer Res. 29:75.1-75.12(2010)

PubMed=21760947; DOI=10.1371/journal.pone.0022023
Delgado O., Kaisani A.A., Spinola M., Xie X.-J., Batten K.G., Minna J.D., Wright W.E., Shay J.W.
Multipotent capacity of immortalized human bronchial epithelial cells.
PLoS ONE 6:E22023-E22023(2011)

PubMed=24240690; DOI=10.1038/onc.2013.486
Zaganjor E., Osborne J.K., Weil L.M., Diaz-Martinez L.A., Gonzales J.X., Singel S.M., Larsen J.E., Girard L., Minna J.D., Cobb M.H.
Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells.
Oncogene 33:5457-5466(2014)

PubMed=29681454; DOI=10.1016/j.cell.2018.03.028
McMillan E.A., Ryu M.-J., Diep C.H., Mendiratta S., Clemenceau J.R., Vaden R.M., Kim J.-H., Motoyaji T., Covington K.R., Peyton M., Huffman K., Wu X.-F., Girard L., Sung Y., Chen P.-H., Mallipeddi P.L., Lee J.Y., Hanson J., Voruganti S., Yu Y., Park S., Sudderth J., DeSevo C., Muzny D.M., Doddapaneni H., Gazdar A.F., Gibbs R.A., Hwang T.-H., Heymach J.V., Wistuba I.I., Coombes K.R., Williams N.S., Wheeler D.A., MacMillan J.B., Deberardinis R.J., Roth M.G., Posner B.A., Minna J.D., Kim H.S., White M.A.
Chemistry-first approach for nomination of personalized treatment in lung cancer.
Cell 173:864-878.e29(2018)

PubMed=32586780; DOI=10.1016/j.resinv.2020.04.005
Sato M., Shay J.W., Minna J.D.
Immortalized normal human lung epithelial cell models for studying lung cancer biology.
Respir. Investig. 58:344-354(2020)

Cell line collections ATCC; CRL-4051
Encyclopedic resources Wikidata; Q54881400
Gene expression databases GEO; GSM253438
GEO; GSM794409
Entry history
Entry creation05-Sep-2014
Last entry update17-Mar-2022
Version number17