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Cellosaurus HBEC3-KT (CVCL_X491)

[Text version]
Cell line name HBEC3-KT
Synonyms HBEC3 KT; HBEC 3KT; HBEC3KT; HBEC3 Cdk4-hTERT; HBEC3
Accession CVCL_X491
Resource Identification Initiative To cite this cell line use: HBEC3-KT (RRID:CVCL_X491)
Comments Part of: Human Protein Atlas, Cell Atlas panel.
Doubling time: 36-48 hours (Evercyte=CkHT-004-0230).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88357; Cdk4.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Large antibody panel staining analysis.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_EQ78 (HBEC3KT53)
Originate from same individual CVCL_D4C2 ! HBEC3-ET
Sex of cell Female
Age at sampling 65Y
Category Telomerase immortalized cell line
STR profile Source(s): ATCC=CRL-4051

Markers:
AmelogeninX
CSF1PO10,11
D5S81812
D7S8208,12
D13S31712,13
D16S5399,12
TH019.3
TPOX11,12
vWA15,17

Run an STR similarity search on this cell line
Web pages Info; HPA; -; https://www.proteinatlas.org/learn/cellines
Publications

PubMed=15604268; DOI=10.1158/0008-5472.CAN-04-3703
Ramirez R.D., Sheridan S., Girard L., Sato M., Kim Y., Pollack J., Peyton M., Zou Y., Kurie J.M., DiMaio J.M., Milchgrub S., Smith A.L., Souza R.F., Gilbey L., Zhang X., Gandia K.G., Vaughan M.B., Wright W.E., Gazdar A.F., Shay J.W., Minna J.D.
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins.
Cancer Res. 64:9027-9034(2004)

PubMed=20079948; DOI=10.1016/j.lungcan.2009.12.005; PMCID=PMC3110769
Gazdar A.F., Gao B., Minna J.D.
Lung cancer cell lines: useless artifacts or invaluable tools for medical science?
Lung Cancer 68:309-318(2010)

PubMed=20624269; DOI=10.1186/1756-9966-29-75; PMCID=PMC2907339
Du L.-Q., Schageman J.J., Irnov I., Girard L., Hammond S.M., Minna J.D., Gazdar A.F., Pertsemlidis A.
MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs.
J. Exp. Clin. Cancer Res. 29:75.1-75.12(2010)

PubMed=21760947; DOI=10.1371/journal.pone.0022023; PMCID=PMC3131301
Delgado O., Kaisani A.A., Spinola M., Xie X.-J., Batten K.G., Minna J.D., Wright W.E., Shay J.W.
Multipotent capacity of immortalized human bronchial epithelial cells.
PLoS ONE 6:e22023.1-e22023.8(2011)

PubMed=24240690; DOI=10.1038/onc.2013.486; PMCID=PMC4025984
Zaganjor E., Osborne J.K., Weil L.M., Diaz-Martinez L.A., Gonzales J.X., Singel S.M., Larsen J.E., Girard L., Minna J.D., Cobb M.H.
Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells.
Oncogene 33:5457-5466(2014)

PubMed=29681454; DOI=10.1016/j.cell.2018.03.028; PMCID=PMC5935540
McMillan E.A., Ryu M.-J., Diep C.H., Mendiratta S., Clemenceau J.R., Vaden R.M., Kim J.-H., Motoyaji T., Covington K.R., Peyton M., Huffman K., Wu X.-F., Girard L., Sung Y., Chen P.-H., Mallipeddi P.L., Lee J.Y., Hanson J., Voruganti S., Yu Y., Park S., Sudderth J., DeSevo C., Muzny D.M., Doddapaneni H., Gazdar A.F., Gibbs R.A., Hwang T.H., Heymach J.V., Wistuba I.I., Coombes K.R., Williams N.S., Wheeler D.A., MacMillan J.B., DeBerardinis R.J., Roth M.G., Posner B.A., Minna J.D., Kim H.S., White M.A.
Chemistry-first approach for nomination of personalized treatment in lung cancer.
Cell 173:864-878.e29(2018)

PubMed=32586780; DOI=10.1016/j.resinv.2020.04.005
Sato M., Shay J.W., Minna J.D.
Immortalized normal human lung epithelial cell models for studying lung cancer biology.
Respir. Investig. 58:344-354(2020)

Cross-references
Cell line collections (Providers) ABM; T0753
ATCC; CRL-4051
Evercyte; CkHT-004-0230
Encyclopedic resources Wikidata; Q54881400
Gene expression databases GEO; GSM171895
GEO; GSM253438
GEO; GSM794409
GEO; GSM7701486
GEO; GSM7701487
Entry history
Entry creation05-Sep-2014
Last entry update10-Apr-2025
Version number25