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Cellosaurus MDCK-MRP2 (CVCL_X022)

[Text version]
Cell line name MDCK-MRP2
Synonyms MDCKII-MRP2; MDCKII-MOAT17
Accession CVCL_X022
Resource Identification Initiative To cite this cell line use: MDCK-MRP2 (RRID:CVCL_X022)
Comments Genetic integration: Method=Transfection; Gene=HGNC; HGNC:53; ABCC2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Caution: There is another MDCK-II cell line with transfected human ABCC2: MDCK2-ABCC2 (Cellosaurus=CVCL_A2JY).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.
Hierarchy Parent: CVCL_0424 (MDCK-II)
Children:
CVCL_9U72 (MDCKII-MRP2/UGT1A1)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=9525973; DOI=10.1172/JCI119886; PMCID=PMC508708
Raymond Evers, Marcel Kool, Liesbeth van Deemter, Hans Janssen, Jero Calafat, Lauran C.J.M. Oomen, Coen C. Paulusma, Ronald P.J. Oude Elferink, Frank Baas, Alfred H. Schinkel, Piet Borst;
Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.
J. Clin. Invest. 101:1310-1319(1998)

PubMed=12134946; DOI=10.1023/A:1016192413308
Fu-Xing Tang, Kazutoshi Horie, Ronald T. Borchardt;
Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?
Pharm. Res. 19:773-779(2002)

Cross-references
Encyclopedic resources Wikidata; Q54904784
Entry history
Entry creation17-Jul-2014
Last entry update14-Aug-2025
Version number14