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Cellosaurus MDCK2-ABCC2 (CVCL_A2JY)

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Cell line name MDCK2-ABCC2
Synonyms MDCK-MRP2; ABCC2-MDCK2
Accession CVCL_A2JY
Resource Identification Initiative To cite this cell line use: MDCK2-ABCC2 (RRID:CVCL_A2JY)
Comments Genetic integration: Method=Transfection; Gene=HGNC; HGNC:53; ABCC2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Caution: There is another MDCK-II cell line with transfected human ABCC2: MDCK-MRP2 (Cellosaurus=CVCL_X022).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.
Hierarchy Parent: CVCL_0424 (MDCK-II)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=24056116; DOI=10.1097/RLI.0b013e3182a70043
Jia Jia, Dorothee Puls, Stefan Oswald, Gabriele Jedlitschky, Jens-Peter Kuhn, Werner Weitschies, Norbert Hosten, Werner Siegmund, Markus Keiser;
Characterization of the intestinal and hepatic uptake/efflux transport of the magnetic resonance imaging contrast agent gadolinium-ethoxylbenzyl-diethylenetriamine-pentaacetic acid.
Invest. Radiol. 49:78-86(2014)

PubMed=25264565; DOI=10.1111/bcp.12522; PMCID=PMC4345960
Werner Siegmund, Christiane Modess, Eberhard Scheuch, Karen Methling, Markus Keiser, Ali Nassif, Dieter Rosskopf, Patrick J. Bednarski, Jurgen Borlak, Bernd Terhaag;
Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1.
Br. J. Clin. Pharmacol. 79:501-513(2015)

Cross-references
Encyclopedic resources Wikidata; Q105510103
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number8